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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Enhanced Offset Averaging Technique for Flash ADC Design显示文摘This paper presents a new combined AC/DC-coupled output averaging technique for input amplifier design of flash analog-to-digital converters (ADC). The new offset averaging design technique takes full advantage of traditional DC-coupled resistance averaging and AC-coupled capacitance averaging techniques to minimize offset-induced ADC nonlinearities. Circuit analysis allows selection of optimum resistance and capacitance averaging factors to achieve maximum offset reduction in ADC designs. The new averaging method is verified in designing a 4 bit 1 Gs/s flash ADC that is implemented in foundry 0.13 μm CMOS technology. | Siqiang FAN He TANG Hui ZHAO Xin WANG Albert WANG Bin ZHAO Gary G ZHANG | 2011 | Tsinghua Science and Technology2011，16，3： | 2 |
| 3 | Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow 显示文摘 | Li X Jin H Bin G | 2009 | Experimental Biol Med2009，234，5： | 1 |
| 4 | Adaptive Wavelet Thresholding for Image Denoising and Compressiong显示文摘 | Chang S G Yu Bin Vetterli M | 2000 | IEEE Transactions on Image Processing2000，9，9： | 1 |
| 5 | Corrison behavior of austenitic stainless steel as a function of methanol concentration for direct methanol fuel cell bipolar plate显示文摘 | Lixia W Bin K Na G | 2014 | J Pow Sour2014，253，： | 1 |
| 6 | Spatially adaptive thresholding with context modeling for image denosing显示文摘 | CHANG S G YU Bin VETTERLI M | 2000 | IEEE Transactions on Image Processing2000，9，9： | 1 |
| 7 | Quantum-mechanical results for a free particle inside abox with general boundary conditions显示文摘 | Da Luz M G E Cheny Bin Kany | 1995 | Phys Rev1995，51，3： | 1 |
| 8 | A reasoned action perspective of user innovation: model and empirical test显示文摘 | BIN G | 2013 | Industrial Marketing Manage- ment2013，42，4： | 1 |
| 9 | A reasoned action perspective of user innovation : Model and empirical test 显示文摘 | Bin G | 2013 | Industrial Marketing Management2013，42，4： | 1 |
| 10 | Microstruture and properties of AZ91D alloy with Ca additions显示文摘 | LI Pei-jie TANG Bin KANDALOVA E G | 2004 | Materials Letters2004，12，： | 1 |
| 11 | Fluid shear stress inhibits TNF- alpha-induced osteoblast apoptosis via ERK5 signaling pathway 显示文摘 | Bin G Cuifang W Bo Z | 2015 | Biochemical and Biophysical Research Communications2015，466，1： | 1 |
| 12 | Surface Studies by Scanning Tunneling Microscopy显示文摘 | Binning G Rohrer H | 1982 | Phy Rev Lett1982，49，1： | 1 |
| 13 | Adaptive wavelet thresholding for image denoi- sing and compression 显示文摘 | CHANG S G YU Bin | 2000 | IEEE Trans on Image Proeessing2000，9，9： | 1 |
| 14 | Surface studies by scanning tunneling microscope 显示文摘 | Binning G Quate C F Gerber Cb | 1982 | Phys Rev Lett1982，49，1： | 1 |
| 15 | Atomic force microscope显示文摘 | BINNING G QUATE C F GERBER C | 1986 | Phys Rev Lett1986，56，9： | 1 |
| 16 | La'_xKxC003 and LaCo'_yFey03 perovskite oxides : Preparation , characterization, and catalytic performance in the simul?taneous removal of NOx and diesel soot显示文摘 | Bin F Song C L Ltl G | 2011 | Industrial and Engneering Chemistry Research2011，50，： | 1 |
| 17 | Atomically flat LPE-grown facets seen by scanning tunneling microscopy显示文摘 | Scheel H J Binning G Rohrer H | 1982 | JCryst Growth1982，60，1： | 1 |
| 18 | Technology acquisition channels and industry per- formance: an industry-level analysis of Chinese large-and medium-size manufacturing enterprises显示文摘 | BIN G | 2008 | Research Poli- cy2008，37，2： | 1 |
| 19 | Atomic force microscopy显示文摘 | Quate C F Gerber C | 1986 | Phys Rev Lett1986，56，9： | 1 |
| 20 | Myeloid cell factor-1 is a critical survival factor for multiple myeloma显示文摘 | BIN ZHANG IVANA GOJO ROBERT G | 2002 | Blood2002，99，6： | 1 |
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