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| 1 | Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies显示文摘Coronavirus disease 2019(COVID-19),caused by the novel human coronavirus SARS-CoV-2,is currently a major threat to public health worldwide.The viral spike protein binds the host receptor angiotensin-converting enzyme 2(ACE2)via the receptor-binding domain(RBD),and thus is believed to be a major target to block viral entry.Both SARS-CoV-2 and SARS-CoV share this mechanism.Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies.The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce strong clade-specific neutralizing antibodies in mice;however,the cross-neutralizing activity was much weaker,indicating that there are distinct antigenic features in the RBDs of the two viruses.This finding was confirmed with the available neutralizing monoclonal antibodies against SARS-CoV or SARS-CoV-2.It is worth noting that a newly developed SARS-CoV-2 human antibody,HA001,was able to neutralize SARS-CoV-2,but failed to recognize SARS-CoV.Moreover,the potential epitope residues of HA001 were identified as A475 and F486 in the SARS-CoV-2 RBD,representing new binding sites for neutralizing antibodies.Overall,our study has revealed the presence of different key epitopes between SARS-CoV and SARSCoV-2,which indicates the necessity to develop new prophylactic vaccine and antibody drugs for specific control of the COVID-19 pandemic although the available agents obtained from the SARS-CoV study are unneglectable. | Chunyan Yi Xiaoyu Sun Jing Ye Longfei Ding Meiqin Liu Zhuo Yang Xiao Lu Yaguang Zhang Liyang Ma Wangpeng Gu Aidong Qu Jianqing Xu Zhengli Shi Zhiyang Ling Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，6： | 13 |
| 2 | Runoff characteristics in flood and dry seasons based on wavelet analysis in the source regions of the Yangtze and Yellow rivers显示文摘由分解并且重建,从 1965~2007 hydrologic 的流量信息与 db3 小浪在黄河的来源区域在长江,和 Jimai 和 Tangnaihai 的来源区域 Tuotuo 驻扎河和 Zhimenda ,不同 hydrologic 车站的流量趋于在 Tuotuo 河里除了那在春天洪水,夏天洪水和干燥的季节正在拒绝。衰退充满 / 弄干季节系列是夏天 > 春天 > 干燥;当 Tuotuo 河的流量总是随更高的增加从 1965 ~ 2007 在不同阶段正在增加时,在春天一比那在夏天洪水季节评价。复杂 Morlet 小浪被选择检测上面提及的四个 hydrologic 车站的流量频率。在所有季节,频率是在黄河的来源区域的 1112 年。为长江的来源区域,频率在夏天洪水季节是在春天洪水季节和 1314 年的 46 年。在黄河和长江的上面的集水区域之间并且在季节之间的流动频率的变化的差别在与的关系被考虑冰川融化并且是的年度降雪和降雨为流量的水的供应商。 | BING Longfei SHAO Quanqin LIU Jiyuan | 2012 | Journal of Geographical Sciences2012，22，2： | 5 |
| 3 | Significance of gypsum-salt rock series for marine hydrocarbon accumulation显示文摘With further exploration and research,the gypsum-salts rock series as good caprocks attracted a lot of attention.The gypsum-salt rock series played an important role during migration,preservation and trapping of hydrocarbons.Recently,major breakthroughs have been continuously made in marine petroleum exploration of gypsum-salt rock series in the eastern Ordos Basin,the central Tarim Basin and the western Sichuan Basin in China,and the high-evolution and low-abundance gypsum-salt rock series as hydrocarbon source rocks become possible.Besides research advances in the reservoirecaprock assemblage of gypsum-salt rock series,development and hydrocarbon-generation potential of source rocks in the gypsum-salt rock series were well studied in terms of source-rock development environment and hydrocarbon generation mechanism.Results showed that the gypsum-salt rock series,including high-evolution and low-TOC gypsum-salt rock series in China,could be regarded as good source rocks.This understanding was a breakthrough to previous traditional viewpoint that low-TOC gypsum-salt rock series could not act as effective hydrocarbon sources.The key to understand hydrocarbon-generation mechanism was that abundant and high-quality hydrocarbon-generation materials,large amount of hydrocarbon generation and conversion in geological history,and hydrocarbongeneration materials occurred in the form of carboxylates,were developed in the high-evolution and low-TOC gypsum-salt rock series. | Wenhui Liu Heng Zhao Quanyou Liu Bing Zhou Dianwei Zhang Jie Wang Longfei Lu Houyong Luo Qingqiang Meng Xiaoqi Wu | 2017 | Petroleum Research2017，2，3： | 2 |
| 4 | Benefit analysis of multi-approach biomass energy utilization toward carbon neutrality显示文摘To reduce greenhouse gas(GHG)emissions,biomass has been increasingly developed as a renewable and clean alternative to fossil fuels because of its carbon-neutral characteristics.China has been investigating the rational development and use of bioenergy for developing its clean energy and achieving carbon neutrality.Substituting fossil fuels with multi-source and multi-approach utilized bioenergy and corresponding carbon reduction in China remain largely unexplored.Here,a comprehensive bioenergy accounting model with a multi-dimensional analysis was developed by combining spatial,life cycle,and multi-path analyses.Accordingly,the bioenergy production potential and GHG emission reduction for each distinct type of biomass feedstock through different conversion pathways were estimated.The sum of all available organic waste(21.55 EJ yr^(-1))and energy plants on marginal land(11.77 EJ yr^(-1))in China produced 23.30 EJ of bioenergy and reduced 2,535.32 Mt CO_(2)-eq emissions,accounting for 19.48%and 25.61%of China’s total energy production and carbon emissions in 2020,respectively.When focusing on the carbon emission mitigation potential of substituting bioenergy for conventional counterparts,bioelectricity was the most effective,and its potential was 4.45 and 8.58 times higher than that of gaseous and liquid fuel alternatives,respectively.In this study,life cycle emission reductions were maximized by a mix of bioenergy end uses based on biomass properties,with an optimal 78.56%bioenergy allocation from biodiesel,densified solid biofuel,biohydrogen,and biochar.The main regional bioenergy GHG mitigation focused on the Jiangsu,Sichuan,Guangxi,Henan,and Guangdong provinces,contributing to 31.32%of the total GHG mitigation potential.This study provides valuable guidance on exploiting untapped biomass resources in China to secure carbon neutrality by 2060. | Jiaoyue Wang Jingying Fu Zhitong Zhao Longfei Bing Fengming Xi Feng Wang Jiang Dong Shiyun Wang Gang Lin Yan Yin Qinqin Hu | 2023 | The Innovation2023，4，3： | 0 |
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