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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Role of β-microseminoprotein from prostate cancer initiationto recurrence: A mini-review显示文摘Medline/Pubmed articles relevant to this topic were considered using the search terms ?-microseminoprotein, MSMB, prostate secretory protein of 94 amino acids and PSP94. Full articles were retrieved when the abstract was considered relevant. In addition, other data related to this topic including our own are discussed. Summary of fi ndings-?-microseminoprotein(MSMB) is increasingly being considered as a marker for prostatecancer, as reduced levels have been associated with the disease. Here we review various aspects of this protein including its biological and physiological variants, binding proteins and immune modulation; its importance as a marker for biochemical recurrence of prostate cancer; prostate cancer related splice variants and its therapeutic utility. Two of the most important properties of MSMB are related to anticancer functions and immune modulation. Predominant expression of two(short and full-length) splice variants of MSMB has been observed from normal prostate and several other tissues. In benign prostate hyperplasia the short isoform is dominant, constituting 98% of this isoform, whereas in prostate cancer 96% constitute the fulllength isoform. The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site. This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions. MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins. MSMB bound to these proteins is considered as immune modulating. Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments, seems possible, but needs further investigation. The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers, with higher ratios indicating severe disease. | Nishi Karunasinghe Karen Bishop Pamela Murray Yuanye Xu Megan Goudie Lance Ng Shuotun Zhu Dug Yeo Han Lynnette R Ferguson Jonathan Masters Benji Benjamin Michael Holmes | 2014 | World Journal of Clinical Urology2014，3，1： | 2 |
| 3 | APOBEC-mediated viral restriction: not simply editing? 显示文摘 | Holmes R K Malim M H Bishop K N | 2007 | Trends Biochem Sci2007，32，3： | 1 |
| 4 | Contingent Valuation of En- vironmental Assets: Comparison with a Stimulated Market 显示文摘 | Bishop R C Heberlein T A Kealy M J | 1983 | Nat- ural Resources Journal1983，23，： | 1 |
| 5 | Napsin A and thyroid transcriptionfactor- 1 expression in carcinomas of the lung,breast,pancreas,colon, kidney, thyroid, and malignant mesothelioma 显示文摘 | Bishop JAtSharma R IlleiPB | 2010 | HumPathol2010，41，： | 1 |
| 6 | An Investigation into the Theory of Resonance Testing显示文摘 | Bishop R E D Gladwell G M L | 1963 | Phil Trans1963，225，22： | 1 |
| 7 | Typhoid fever in travelers: who should be targeted for prevention? 显示文摘 | STEINBERG E B BISHOP R HABER P | 2004 | Clin Infect Dis2004，39，2： | 1 |
| 8 | Enhanced deposition of predominantly typeI collagen in myocardial disease显示文摘 | Bishop J E Greenbaum R Gibsonj D G | 1990 | J Mel Cell Cardiol1990，22，10： | 1 |
| 9 | A Novel Whiskerless Schottky Diode for Millimeter and Submillimeter Wave Application显示文摘 | Bishop W L Mchinney K Mattanch R J | 1987 | Microwave Symposium Digest MTT-S International1987，87，2： | 1 |
| 10 | The Fifth Annual Fairley Lecture on the Linear Representation of Fluid Forces and Movements in Unsteady Flow显示文摘 | Bishop R E D Burcher R K Price W G | 1973 | Journal of Sound and Vibration1973，29，1： | 1 |
| 11 | The onset of chaotic motions of a moored semi-submersible显示文摘 | Bishop S R Virgin L N | 1988 | Journal of OMAE1988，110，： | 1 |
| 12 | Trapping parasite secretory proteins in baker's yeast显示文摘 | NENE V BISHOP R | 2001 | Trends Parasitol2001，17，9： | 1 |
| 13 | Early clinical experience with a new videolaryngoscope (GlideScope) in 728 patients显示文摘 | Cooper R M Pacey J A Bishop M J McCluskey S A | 2005 | Can J Anaesth2005，52，： | 1 |
| 14 | Heparan sulphate proteoglycans fine- tune mammalian physiology显示文摘 | Bishop J R Schuksz M Esko J D | 2007 | Natute2007，446，7139： | 1 |
| 15 | Subacute digoxintoxicosis in the Beagle Dog显示文摘 | Teske R H Bishop S P Righter H F | 1976 | Toxicology and Applied Phar-macology1976，35，： | 1 |
| 16 | Molecu- lar cloning of human mevalonate kinase and identifica- tion of a missense mutation in the genetic disease meval- onic aciduria 显示文摘 | Schafer B L Bishop R W Kratunis V J | 1992 | J Biol Chem1992，267，13： | 1 |
| 17 | Napsin A and thyroid transcriptionfactor-I expression in carcinomas of the lung,breast,pancreas,colon,kidney,thyroid,and malignant mesothelioma显示文摘 | Bishop J A Sharma R Illei P B | 2010 | Hum Pathol2010，41，1： | 1 |
| 18 | The pyrolysis of tobacco in- gredients显示文摘 | BAKER R R BISHOP L J | 2004 | J Anal Appl Pyrolysis2004，71，1： | 1 |
| 19 | Homozygosityfor a single base-pair mutation in the oocyte-specificGDF9 gene results in sterility in Thoka sheep显示文摘 | Nicol L Bishop S C Pong-Wong R | 2009 | Repro-duction2009，138，6： | 1 |
| 20 | Interplanetary flyby mission optimization using a hybrid global/local search method显示文摘 | Crain T P Bishop R H Fowler W T | 2000 | Journal of Spacecraft and Rockets2000，37，4： | 1 |
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