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| 1 | Helicobacter pylori infection: Beyond gastric manifestations显示文摘Helicobacter pylori(H.pylori)is a bacterium that infects more than a half of world’s population.Although it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric diseases.According to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological conditions.In that context,when considered the gastrointestinal tract,H.pylori positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and Cholecystitis.Moreover,lower serum levels of iron and vitamin B12 have been found in patients with H.pylori infection,leading to the emergence of anemias in a portion of them.With regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barrésyndrome.Interestingly,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the infection.Besides that,the H.pylori-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected individuals.Finally,the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism.In this sense,this minireview aims to gather the main studies associating H.pylori infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of H.pylori in those diseases. | Maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo | 2020 | World Journal of Gastroenterology2020，26，28： | 34 |
| 2 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 3 | Coronary artery disease detected by coronary computed tomographic angiography is associated with intensification of preventive medical therapy and lower low-density lipoprotein cholesterol 显示文摘 | Hulten E Bittencourt MS Singh A | 2014 | Cire Cardiovasc Imaging2014，7，4： | 1 |
| 4 | Outcomes after coronary computed tomography angiography in the emergency department: a systematic review and meta- analysis of randomized, controlled trials 显示文摘 | Hulten E Pickett C Bittencourt MS | 2013 | J Am Coll Cardiol2013，61，8： | 1 |
| 5 | Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocom- patibility barriers显示文摘 | Bittencourt MC Penuche S Contassot E | 2001 | Blood2001，98，1： | 1 |
| 6 | Detection andquantification of CSF malignant cells by the cell search technologyin patients with melanoma leptomeningeal metastasis显示文摘 | Le Rhun E Tu Q De Carvalho Bittencourt M | 2013 | Med Oncol2013，30，2： | 1 |
| 7 | WO3 films modified with functionalised multi-wall carbon nanotubes: Morphological, compositional and gas response studies显示文摘 | Bittencourt C Felten A Espinosa E H | 2006 | Sensors and Actuators B2006，115，1： | 1 |
| 8 | Compatibility of the fungus Metarhizium anisopliae and deltamethfin to control a resistant strain of Boophilus microplus tick显示文摘 | Bahiense T C Femandes E K Bittencourt V R | 2006 | Veterinary Parasitology2006，141，： | 1 |
| 9 | Finite element analysis of three-dimensional contact and impact in large deformation problems显示文摘 | BITTENCOURT E GUILLERMO J | 1998 | Computers & Structures1998，69，2： | 1 |
| 10 | Radiograph?ic characteristics of furcation involvements in mandibular molars as prognostic indicators of healing after nonsurgical periodontal therapy显示文摘 | Do-Vale H F Del-Peloso-Ribeiro E Bittencourt S | 2009 | J Am Dent Assoc2009，140，4： | 1 |
| 11 | Outcomes after coro- nary computed tomography angiography in the emergency depart-ment: a systematic review and meta - analysis of randomized, con- trolled triMs显示文摘 | Hulten E Pickett C Bittencourt MS | 2013 | J Am Coll Cardiol2013，61，8： | 1 |
| 12 | Occurrence of virulence-asso- ciated genes in clinical Enterococcus faecalis strains isolated in Londrina, Brazil 显示文摘 | Bittencourt de Mazques E Suzart S | 2004 | J Med Microbiol2004，53，11： | 1 |
| 13 | Constitutive models for cohesive zones in mixed-mode fracture of plain concrete显示文摘 | Lens L N Bittencourt E Avila V M R | 2009 | Engineering Fracture Mechanics2009，76，： | 1 |
| 14 | Prognostic value of nonobstructive and obstructive coronary artery disease detected by coronary computed tomography angiography to identify cardiovascular events显示文摘 | Bittencourt MS Hulten E Ghoshhajra B | 2014 | Circ Cardiovasc Imaging2014，7，28： | 1 |
| 15 | Compatibility of the fungus Metarhizium anisopliae and deltamethrin to control a resistant strain of Boophilus microplus tick显示文摘 | Bahiense T C Fernandes E K Bittencourt V R | 2006 | Veterinary Parasitology2006，141，34： | 1 |
| 16 | A performanceoriented adaptive scheduler for dependent tasks on grids显示文摘 | Bittencourt L F Madeira E R M | 2008 | Concurrency and Computation: Practice and Experience2008，20，9： | 1 |
| 17 | A computational model for developing semantic Web-based educational systems 显示文摘 | BITTENCOURT I COSTA E SILVA M | 2009 | Knowledge-based Systems2009，22，4： | 1 |
| 18 | Immune response to Helicobacter pylori infection and gastric cancer development显示文摘Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(H.pylori)infection is the main risk factor for its occurrence.Of note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this setting.The development of an inflammatory process against H.pylori involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial cells.This process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper cells.Cytokines released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ways.Moreover,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its receptor.In addition,various repercussions related to some H.pylori virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis. | Breno Bittencourt de Brito Fabian Fellipe Bueno Lemos Caroline da Mota Carneiro Andressa Santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de Souza Assis Barbara Dicarlo Costa Braga Maria Luísa Cordeiro Santos Filipe Antônio França da Silva Hanna Santos Marques Natália Oliveira e Silva Fabrício Freire de Melo | 2021 | World Journal of Meta-Analysis2021，9，3： | 1 |
| 19 | The impact of pre-formed and in situ spinel formation on the physical properties of cement-bonded high alumina refractory castables 显示文摘 | Sako E Y Braulio M A L Bittencourt L R M | 2010 | Ceramics Intermational2010，36，7： | 1 |
| 20 | Compatibility of the fiingus Metarhizium anisopliae and deltamethrin to controla resistant strain of Boophilus microplus tick显示文摘 | Bahiense T C Fernandes E K Bittencourt V R | 2006 | VetParasitology2006，141，34： | 1 |
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