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| 1 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 2 | Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encepha-lopathy显示文摘肝的脑病(他) 普通 neuro 精神病学的畸形,它从肝细胞失败或 portosystemic 与肝疾病和结果复杂化病人的功课正在推延。表明他是广泛地可变的并且从温和无临床症状的骚乱包含一个系列到深昏迷。研究兴趣集中于传播导出勇气的毒素的角色,特别地氨,胀大的大脑的开发和在导致全球 CNS 消沉和混乱功能的服的 neurotransmitter 系统的变化。直到最近,服的功能的直接调查有在人是困难的。然而,当磁性的回声光谱学( 1H 太太)检测的质子在大脑生物化学变化时,新磁性的回声成像( MRI )技术在大脑体积( coregistered MRI )和损害大脑功能( fMRI )提供对变化的评价的一个非侵略的工具,包括服的 osmolytes 的直接测量,例如 myoinositol ,充斥管理对细胞的动态平衡内在的过程的使挫折和夫酸安,包括细胞内部的水的累积。这些细胞内部的 osmolytes 的集中与 hyperammonaemia 改变。有 neuropsychiatric 缺陷并且自从先生系列的严厉的检测太太的代谢物畸形相互关联向正常术后疗法回来,技术可能具有在客观耐心的监视并且在估计各种各样的治疗政体的有效性的使用。 | VP Bob Graver M Alex Dresner Daniel M Forton Serena Counsell David J Larkman Nayna Patel Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，19： | 8 |
| 3 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 4 | 胶管胶带用硫化剂和防老剂显示文摘越来越高的汽车发动机温度对在汽车中使用的胶管和胶带用聚合物提出了更严格的要求。本文综述了胶管和胶带中使用的聚合物,并针对提高耐热、耐屈挠疲劳和耐臭氧老化性能讨论了每一种聚合物用的硫化体系和防老剂搭配。 | Sinha D P Jablonowski Tom Ohm Bob Vanis Vern 黄向前 | 2002 | 橡胶工业2002，49，12： | 2 |
| 5 | Reduced adsorption and separation of blended surfaetants on sand and clay 显示文摘 | D Bob O Tom | 1991 | Can Pet Technol1991，30，2： | 1 |
| 6 | An Improved Optimization Algorithm and a Bayes Factor Termination Criterion for Sequential Projection Pursuit显示文摘 | Bobbie J M Webb-Robertson Kristin H J Scott D H Christian P Bob W W | 2005 | Chemometrics and Intelligence Laboratory Systems2005，77，12： | 1 |
| 7 | Induced disease resistance in plants by chemicals显示文摘 | Michael O Walter K Bob D | 2001 | European Journal of Plant Pathology2001，107，1： | 1 |
| 8 | Grazing intensity and ecosystem processes in a northern mixed-grass prairie,USA显示文摘 | Mario E B Bob D P Paul E N | 1998 | Ecological Applications1998，8，： | 1 |
| 9 | Proanthocyanidins from the American Cranberry(Vaccinium macrocarpon)inhibit matrix metalloproteinase-2and matrixmetalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways显示文摘 | Bob A Déziel Kunal Patel Katherine Gottschall-Pass | 2010 | Journal of Cellular Biochemistry2010，111，3： | 1 |
| 10 | Much ado about nothing long-term memory in Pacific rim equity markets显示文摘 | Howe J S Martin D W Bob G Wood J | 1999 | International Review of Financial Analysis1999，8，2： | 1 |
| 11 | Purification of flagellar cores of vibrio cholerae显示文摘 | Yang Ene C H Gordon D Schrank Bob A freemen | 1977 | Journal of Bacteriology1977，192，2： | 1 |
| 12 | Induced disease resistance in plants by chemicals 显示文摘 | Michael O Walter K Bob D Staub T | 2001 | European Journal of Plant Pathology2001，107，1： | 1 |
| 13 | The replacement of cadmium as a thermal neutron filter显示文摘 | Bob D’Mellow David J Thomas Malcolm J Joyce | 2007 | Nuclear Instruments and Methods in Physics Research A2007，577，3： | 1 |
| 14 | Transurethral microwave thermotherapy for treatment of benign prostatic hyperplasia 显示文摘 | MATTIAS W BOB D | 2004 | JMHG2004，1，23： | 1 |
| 15 | Histological,immunohistochemical and biological data in assessing interstitial fibrosis in patients with chronic glomerulonephritis显示文摘 | Bob FR Gluhovschi G Herman D | | 0，，03： | 1 |
| 16 | An Improved Strategy for Main- taining Repeat Ground Tracks at High Latitudes 显示文摘 | Peter D Schutz Bob E | 2000 | Ad- vances in the Astronautical Sciences2000，105，2： | 1 |
| 17 | Grazing intensity and ecosystem processes in a northern mixed-grass prairie, USA显示文摘 | Biondini M E Bob D P Paul E N | 1998 | Ecological Applications1998，8，： | 1 |
| 18 | A randomized clinical trail on a comprehensive geriatric assessment and intensive home follow - up after hospital discharge: the Transitional Care Bridge显示文摘 | Bianca Mb Juliette L P Bob A J D | 2010 | BMC Health Services Research2010，10，1： | 1 |
| 19 | A market managed multi-service internet显示文摘 | Bob B Vasilios D Oliver H | 2003 | Computer Communications2003，26，4： | 1 |
| 20 | Grazing Intensity and Ecosystem Processes in a Northern Mixed-Grass Prairie, USA显示文摘 | MARIO E B BOB D P PAUL E N | 1998 | Ecological Applications1998，8，2： | 1 |
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