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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Temperature-dependent oxygen extract ion from the ventilatory current and thecosts of ventilation in the cephalopod Sepia officinalis 显示文摘 | Melzner F Bock C Portner H O | 2006 | J Comp Physiol B: Biochem Syst Environ Physiol2006，176，7： | 1 |
| 3 | OrganellarGenomeDRAW (OGDRAW): A tool for the easy generation of highquality custom graphical maps of plastid and mitochondrial genomes显示文摘 | Lohse M Drechsel O Bock R 2007 | 2007 | Current Genetics2007，52，： | 1 |
| 4 | Temperature-dependent oxygen extraction from the ventilatory current and the costs of ventilation in the cephalopod Sepia officinalis 显示文摘 | MELZNER F BOCK C PORTNER H O | 2006 | Journal of Comparative Physiology B : Biochemical Systemic and Environmental Physiology2006，176，7： | 1 |
| 5 | Studies of transforming growth factors beta 1-3 and their receptors Ⅰ and Ⅱ in fibroblast of keloids and hypertrophic scars显示文摘 | Bock O Yu H Zitron S | 2005 | Acta Derm Venereol2005，85，3： | 1 |
| 6 | Studies of transforming growth factors beta 1 - 3 and their receptors Ⅰ and Ⅱ in fibrobast of keloids and hypertrophic scars显示文摘 | Bock O Yu H Zitron S | 2005 | Acta Derm Venereol2005，85，3： | 1 |
| 7 | Studies of transforming growth factors beta 1-3 and their receptors I and 1~ in fibroblast of keloids and hypertrophic scars显示文摘 | Bock O Yu H Zitron S | 2005 | Acta Derm Venereol2005，85，3： | 1 |
| 8 | In vitro corneal permeability of diclofenac sodium in formulations containing cyclodextrins compared to the commercial product voltaren ophtha 显示文摘 | Reer O Bock T K Muller B W | 1994 | Journal of Pharmaceutic Sciences1994，83，9： | 1 |
| 9 | Genetic susceptibility to keloid disease: transforming growth factor beta receptorgene polymorphisms are not associated with keloid disease 显示文摘 | Bayat A Bock O Mrowietz U | 2004 | Exp Dermatol2004，13，2： | 1 |
| 10 | Quality of life of patients with keloid and hypertrophic scarring 显示文摘 | Bock O Schmid-Ott G Malewski P | 2006 | Arch Dermatol Res2006，297，10： | 1 |
| 11 | Genetic susceptibility to keloid disease and hypertrophic scarring:transforming growth factor betal common polymorphisms and plasma levels 显示文摘 | Bayat A Bock O Mrowietz U | 2003 | Plast Reeonstr Surg2003，111，2： | 1 |
| 12 | Genetic susceptibility to keloid diseaseand hypertrophic scaring: transforming growth factorβ 1 commonpolymorphisms and plasma levels显示文摘 | Bayat A Bock O Mrowietz U | 2003 | Plast Reconstr Surg2003，111，： | 1 |
| 13 | The effect of inhomogeneities in the lower atmosphere on coordinates determined from GPS measurements显示文摘 | Bock O Tarniewicz J Thom C Pelon J | 2002 | Physics and Chemistry of the Earth2002，27，： | 1 |
| 14 | Tempera-ture-dependent oxygen extraction from theventilatory current and the costs of ventila-tion in the cephalopod Sepia officinalis显示文摘 | Melzner F Bock C Portner H O | 2006 | Journal of Comparative Physiology B2006，176，7： | 1 |
| 15 | Genetic susceptibility to keloid diseaseand hypertrophic scaring:transforming growth factor β1 commonpolymorphisms and plasma levels显示文摘 | Bayat A Bock O Mrowietz U | | 0，，： | 1 |
| 16 | New concepts of microbial treatment processes for the nitrogen removal in wastewater显示文摘 | Schmidt I Sliekers O Schmid M Bock E Fuerst J Kuenen J G Jetten M S M Strous M | 2003 | FEMS Microbiology Reviews2003，27，4： | 1 |
| 17 | Mesoscale GPS tomography applied to the 12 June 2002 convective initiation event of IHOP_2002 显示文摘 | Champollion C Flamant C Bock O | 2009 | Quarterly Journal of the Royal Meteorological Society2009，135，640： | 1 |
| 18 | Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor betal common polymorphisms and plasma levels 显示文摘 | BAYAT A BOCK O MROWIETZ U | 2003 | Plast Reconstr Surg2003，111，2： | 1 |
| 19 | Genetic susceptibility tokeloid disease and hypertrophic scarring:transforming growth factor betal common polymorphisms and plasma levels显示文摘 | Bayat A Bock O Mrowietz U | 2003 | Plast Reconstr Surg2003，111，2： | 1 |
| 20 | Studies of transforming growth factors beta 1-3 and their receptors I and II in fibroblast of keloids and hypertrophic scars 显示文摘 | Bock O Yu H Zitron S | 2005 | Acta Derm Venereol2005，85，3： | 1 |
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