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48篇 您的检索式:作者名="BODINE PV"
    题名 作者 年代 出处 被引量
1Wnt signaling control of bone cell apoptosis显示文摘Wnts 是调停的生长因素的一个大家庭象胚胎开始,形态发生和瀑形成一样的必要生物学过程。这些蛋白质也在 oncogenesis 起一个作用,并且他们在许多纸巾调整 apoptosis。Wnts 把 G-protein-coupled 受体和低密度的脂蛋白(LDL ) 绑在由 frizzled (FZD ) 组成的膜受体建筑群受体相关的蛋白质(LRP ) 。这 ligand 受体建筑群的形成开始象几条不在经典中的小径一样包括 canonical/beta-catenin 小径的很多发信号的串联。在最近的年里,发信号的正规 Wnt 被报导了在骨生成的控制起一个重要作用。临床的研究发现了在 LRP-5 的变化与减少的骨头矿物质密度(BMD ) 和破裂被联系。Wnt 小径部件的猛烈、转基因的老鼠模型的调查证明了发信号的正规 Wnt 包括增长,区别,功能和 apoptosis 调制造骨细胞生理学的大多数方面。在骨头表示 LRP-5 的函数异种的获得的转基因的鼠标,或缺乏 Wnt 对手的鼠标分泌了卷发相关的 protein-1,展出提高的 BMD 和压制的造骨细胞 apoptosis。另外,有象禁止肝糖 synthase kinase-3beta 的那些那样的 pharmacologic 混合物的现出症状之前的潜的研究在骨生成和造骨细胞 apoptosis 的调整支持正规 Wnt 小径的重要性。Bodine,PV 2008Cell Research2008,18,2:30
2The Wnt antago- nist secreted frizzled-related protein-1 is a negative regu- lator of trabecular bone formation in adult mice 显示文摘Bodine PV Zhao W Kharode YP 2004Mol Endocrinol2004,18,5:1
3Wnt signaling and osteoblasto- genesis 显示文摘Bodine PV Komm BS 2006Rev Endocr Metab Disord2006,7,12:1
4A small molecule inhibitor of the Wnt antagonist secreted friz- zled-related protein-1 stimulates bone formation显示文摘Bodine PV Stauffer B Ponce-de-Leon H 2009Bone2009,44,6:1
5Evidence that conditionally immortalized hu- man osteoblasts express an osteocalcin receptor显示文摘Bodine PV Komm BS 1999Bone1999,25,5:1
6Bazedoxifene Acetate:a selective estrogen receptor modulator with improved selectivity显示文摘KOMN BS KHARODE YP BODINE PV 2005Endocrinology2005,146,9:1
7Wnt signaling and osteoblastogenesis显示文摘Bodine PV Komm BS 0,,1:1
8Development and characterization of a conditionally transformed adult human osteoblastic cell line显示文摘Bodine PV Trailsmith M Komm BS 0,,06:1
9Wnt signaling and osteoblastogen- esis显示文摘Bodine PV Komm BS 2006Rev Endocr Metab Disord2006,7,:1
10Wnt signaling and osteoblastogenesis显示文摘Bodine PV KommBS 2006RevEndocr Metab Disord2006,7,12:1
11Estrogen receptor-α is developmentally regulated during osteoblast differentiation and contributes to selective responsiveness of gene expression显示文摘Bodine PV Henderson RA Green J 1998Endocrinology1998,139,4:1
12Estrogen receptor-alpha is developmentally regulated during osteoblast differentiation and contributes to selective responsiveness of gene expression显示文摘Bodine PV Henderson RA Green J 0,,04:1
13The orphan receptor tyrosine ki- nase Ror2 modulates canonical Wnt signaling in osteoblastic cells 显示文摘Billiard J Way DS Seestaller-Wehr LM Moran RA Mangine A Bodine PV 2005Mol Endocrinol2005,19,1:1
14Evidence that conditionally immortalized human osteoblasts express an osteocalcin receptor显示文摘Bodine PV Komm BS 1999Bone1999,25,5:1
15A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation显示文摘Bodine PV Stauffer B Ponce-de-Leon H 0,,6:1
16WntSa induces homodimerization and activation of Ror2 receptor tyrosine ki- nase 显示文摘Liu Y Rubin B Bodine PV Billiard J 2008J Cell Biochem2008,105,2:1
17A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation显示文摘Bodine PV Stauffer B Ponce-de-Leon H 2009Bone2009,44,:1
18A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation显示文摘Bodine PV Stauffer B Ponce-de-Leon H 2009Bone2009,44,6:1
19Development and charac- terization of a conditionally transformed adult human osteoblastic cell line显示文摘Bodine PV Trailsmith M Komm BS 1996J Bone Miner Res1996,11,6:1
20The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis显示文摘Bodine PV Billiard J Moran RA 2005Journal of Cellular Biochemistry2005,96,6:1
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