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| 1 | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases显示文摘Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function.Dysregulation of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular carcinoma.However,the precise role of HNF4αin the etiology of these human pathogenesis is not well understood.Limited information is known about the role of HNF4αisoforms in liver and gastrointestinal disease progression.There is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes.In this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal diseases.We further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches. | Matthew M Yeh Dustin E Bosch Sayed S Daoud | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 2 | Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes显示文摘 | Li GR Yang B Feng J Bosch RF Carrier M Nattel S | 1999 | Am J Physiol1999，276，12： | 2 |
| 3 | Epidemiology and natural history of human papillomavirus infections and type - specific implications in cervical neoplasia 显示文摘 | Bosch FX Burchell AN Schiffman M Giuliano AR de Sanjose S Bruni L | 2008 | Vaccine2008，26，10： | 1 |
| 4 | Vectorial structure of nonparaxial electromagnetic beams显示文摘 | Martinez-Herrero R Mejias P M Bosch S | 2001 | J Opt Soc Am A2001，18，7： | 1 |
| 5 | Phase,Ⅰ-Ⅱ study of escalating doses of amifostine combined with high-dose cyclophosphamide显示文摘 | Ghielmini M Van der Bosch S Bosshard M | 2001 | Cancer Chemother Pharmacol2001，，6： | 1 |
| 6 | Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance显示文摘 | de Smet M Langereis S van den Bosch S | 2010 | J Controlled Release2010，143，1： | 1 |
| 7 | Simple mathematical models for cannibalism: a critique and a new approach显示文摘 | Diekmann O Nisbet R M Gurney W S C F vanden Bosch | 1986 | Math Biosci1986，78，： | 1 |
| 8 | Preoperative MRI and surgical management in patients with nonpalpable breast cancer:the MONET-randomised controlled trial显示文摘 | Peters N Van Esser S van den Bosch M | 2011 | Euro J Canc- er2011，47，6： | 1 |
| 9 | Inversion of traveltime data under a statistical model for seismic velocities and layer interfaces显示文摘 | Bosch M Barton P Singh S C | 2005 | Geophysics2005，70，4： | 1 |
| 10 | Temperaturesensitive liposomes for doxorubicin delivery under MRI guidance显示文摘 | de Smet M Langereis S den Bosch S | 2010 | J Control Release2010，143，1： | 1 |
| 11 | New tools for the study and direct surveillance of viral pathogens in water显示文摘 | Bosch A Guix S Sano D PintóR M | 2008 | Curr Opin Biotechnol2008，19，3： | 1 |
| 12 | Phase I- of amifostine combined with high dose cyclophosphamide 显示文摘 | Ghielmini M Van Bosch S II study of escalating doses Bosshard M | 2001 | Cancer Chmother Pharmacol2001，47，6： | 1 |
| 13 | Temperature- sensitive liposomes for doxorubicin delivery under MRI guid- ance 显示文摘 | De Smet M Langereis S Vanden Bosch S | 2010 | Controlled Release2010，143，1： | 1 |
| 14 | Factors influencing begomovirus evolution and their increasing global significance:implications for sustainable control显示文摘 | Seal S van den Bosch F Jeger M | | 0，，： | 1 |
| 15 | Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the middle east respiratory syndrome coronavirus显示文摘 | Rai V S Stairs S L Provaeia L B van den Brand J M Wiersma L Ouwendijk W J Bestebroer T M Spronken M I van Amerongen G Rottier P J Foueh- ier R A Bosch B J Osterhaus A D Haagmans B L | 2014 | J Virol2014，88，18： | 1 |
| 16 | Activity Recognition Using Inertial Sensing for Heahhcare Wellbeing and Sports Applications : A Survey 显示文摘 | Avci A Bosch S Marin-Perianu M | 2010 | Architecture of Computing Systems ( ARCS )2010，23，： | 1 |
| 17 | Tempera- / ture-sensitive liposomes for doxorubicin delivery under MRI guidance 显示文摘 | de Smet M Langereis S van den Bosch S | 2010 | J Control Release2010，143，1： | 1 |
| 18 | Preoperative MRI and surgical management in patients with nonpalpable breast cancer: the MONET - rmldomised controlled trial 显示文摘 | Peters N Van Esser S van den Bosch M | 2011 | European Journal of Canc- er2011，47，6： | 1 |
| 19 | Class III pistil-specific extensin-like proteins from tobacco have characteristics of arabinogalactan proteins显示文摘 | Bosch M Knudsen J S Derken J Mariani C | 2001 | Plant Physiol2001，125，： | 1 |
| 20 | Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial显示文摘 | Jorma Paavonen David Jenkins F Xavier Bosch Paulo Naud Jorge Salmerón Cosette M Wheeler Song-Nan Chow Dan L Apter Henry C Kitchener Xavier Castellsague Newton S de Carvalho S Rachel Skinner Diane M Harper James A Hedrick Unnop Jaisamrarn Genara AM Limson | 2007 | The Lancet2007，，9580： | 1 |
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