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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | PI controller relay auto-tuning using delay and phase margin in PMSM drives显示文摘This paper presents an auto-tuning method for a proportion plus integral(PI) controller for permanent magnet synchronous motor(PMSM) drives, which is supposed to be embedded in electro-mechanical actuator(EMA) control module in aircraft. The method, based on a relay feedback with variable delay time, explores different critical points of the system frequency response.The Nyquist points of the plant can then be derived from the delay time and filter time constant.The coefficients of the PI controller can then be obtained by calculation while shifting the Nyquist point to a specific position to obtain the required phase margin. The major advantage of the autotuning method is that it can provide a series of tuning results for different system bandwidths and damping ratios, corresponding to the specification for delay time and phase margin. Simulation and experimental results for the PMSM controller verify the performance of both the current loop and the speed loop auto-tuning. | Wang Lina Xiao Kun Liliana de Lillo Lee Empringham Pat Wheeler | 2014 | Chinese Journal of Aeronautics2014，27，6： | 4 |
| 3 | Investigation of the preparation methodologies of Pd-Cu single atom alloy catalysts for selective hydrogenation of acetylene显示文摘流电的代替,合作受精和顺序的受精被采用了准备 Pd-Cu 有不到 1 wt-% Cu 和 ca 的二金属的催化剂。为在过量乙烯的乙炔的选择加氢的 0.03 wt-% Pd。高角度环形的黑暗扫描地的传播电子显微镜学(HAADF 茎) 和 H 2 化学吸着结果证实 Pd-Cu singleatom 合金结构在所有三二金属的催化剂被构造。催化测试显示当乙炔的变换超过 99% 时,这三单个原子合金催化剂的乙烯的选择仍然是超过 73% 。而且,顺序的早期的湿受精准备的单个原子合金催化剂被发现在使用的三个过程之中有最好的稳定性。 | Xinxiang Cao Arash Mirjalili James Wheeler Wentao Xie Ben W.-L. Jang | 2015 | Frontiers of Chemical Science and Engineering2015，9，4： | 4 |
| 4 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 5 | Simulating the Impacts of Global Warming on Wheat in China Using a Large Area Crop Model显示文摘Temperature is one of the most prominent environmental factors that determine plant growth,development, and yield.Cool and moist conditions are most favorable for wheat.Wheat is likely to be highly vulnerable to further warming because currently the temperature is already close to or above optimum.In this study,the impacts of warming and extreme high temperature stress on wheat yield over China were investigated by using the general large area model(GLAM) for annual crops.The results showed that each 1℃rise in daily mean temperature would reduce the average wheat yield in China by about 4.6%-5.7% mainly due to the shorter growth duration,except for a small increase in yield at some grid cells.When the maximum temperature exceeded 30.5℃,the simulated grain-set fraction declined from 1 at 30.5℃to close to 0 at about 36℃.When the total grain-set was lower than the critical fractional grain-set(0.575-0.6), harvest index and potential grain yield were reduced.In order to reduce the negative impacts of warming, it is crucial to take serious actions to adapt to the climate change,for example,by shifting sowing date, adjusting crop distribution and structure,breeding heat-resistant varieties,and improving the monitoring, forecasting,and early warning of extreme climate events. | 李三爱 Tim Wheeler Andrew Challinor 林而达 许吟隆 居辉 | 2010 | Acta meteorologica Sinica2010，24，1： | 3 |
| 6 | The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells显示文摘 | Lee Tuddenham Guy Wheeler Sofia Ntounia-Fousara Jasmine Waters Mohammad K. Hajihosseini Ian Clark Tamas Dalmay | 2006 | FEBS Letters2006，，17： | 3 |
| 7 | An assessment of direct and indirect effects of climate change for populations of the Rocky Mountain Apollo butterfly ( Parnassius smintheus Doubleday)显示文摘气候变化正在发生,昆虫正在反应。为生态学家和经理的当前的挑战正在预言有机体怎么将对继续气候变化并且决定怎么减轻潜在的否定效果作出回应。与为包含种类的分发的气候变化的宽广规模预言相对照,在这篇文章,我们加亮岩石山阿波罗蝴蝶(Parnassius smintheus Doubleday ) 的本地人口在被预言对气候变化作出回应的许多方法。用在过去的 15 年收集的试验性、观察的数据,我们详细说明直接、间接的效果。另外,我们鉴别在我们限制能力预言人口怎么将对气候作出回应的知识的限制变化。一些变化例如更温暖的冬季温度,可以有有益的效果;然而,大多数气候变化的效果将是有害的。在雪盖子的可变性在 overwintering 期间,时期和产地损失由于森林侵入有最大的潜在的否定效果。 | Stephen F. Matter Amanda Doyle Kurt Illerbrun Jeanette Wheeler Jens Roland | 2011 | Insect Science2011，18，4： | 3 |
| 8 | The Voisey's Bay Ni-Cu-Co Sulfide Deposit, Labrador, Canada: Emplacement of Silicate and Sulfide-Laden Magmas into Spaces Created within a Structural Corridor显示文摘The Voisey's Bay Ni-Cu-Co sulfide deposit is hosted in a 1.34 Ga mafic intrusion that is part of the Nain Plutonic Suite in Labrador, Canada.The Ni-Cu-Co sulfide mineralization is associated with magmatic breccias that are typically contained in weakly mineralized olivine gabbros, troctolites and ferrogabbros, but also occur as veins in adjacent paragneiss.The mineralization is associated with a dyke-like body which is termed the feeder dyke.This dyke connects the shallow differentiated Eastern Deeps chamber in the east to a deeper intrusion in the west termed the Western Deeps Intrusion.Where the conduit is connected to the Eastern Deeps Intrusion, the Eastern Deeps Deposit is developed at the entry line of the dyke along the steep north wall of the Eastern Deeps Intrusion.The Eastern Deeps Deposit is surrounded by a halo of moderately to weakly mineralized Variable-Textured Troctolite (VTT) that reaches a maximum thickness above the ENE-WSW axis of the Eastern Deeps Deposit. At depth to the west, the conduit is adjacent to the south side of the Western Deeps Intrusion, where the dyke and intrusion contain disseminated magmatic sulfide mineralization.The Reid Brook Zone plunges to the east within the dyke, and both the dyke and adjacent paragneiss are mineralized.The Ovoid Deposit comprises a bowl-shaped body of massive sulfide where the dyke widens near to the present-day surface.It is not clear whether this deposit was developed as a widened-zone within the conduit or at the entry point into a chamber that is now lost to erosion. The massive sulfides and breccia sulfides of the Eastern Deeps are petrologically and chemically different when compared to the disseminated sulfides in the VTT; there is a marked break in Ni tenor (Ni content in 100% sulfide, abbreviated to [Ni]100) and Ni/Co of sulfide between the two.The boundary of the sulfide types is often marked by strong sub-horizontal alignment of heavily digested and metamorphosed paragneiss fragments, development of barren olivine gabbro, and by a change from typically massive sulfides and breccias sulfides into more typical variable-textured troctolites with heavy to weak disseminated sulfide.Sulfides hosted in the feeder dyke tend to have low metal tenors ([Ni]100=2.5%-3.5%); sulfides in Eastern Deeps massive and breccia ores have intermediate Ni tenors ([Ni]100=3.5%-4%) and disseminated sulfides in overlying rocks have high Ni tenors ([Ni] 100=4%-8%) . Conduit-hosted mineralization and mineral zones in the paragneiss adjacent to the Reid Brook Deposit tend to have lower Ni tenor than the Ovoid and Eastern Deeps Deposits.The tenor of mineral hosted in the country rock gneisses tends to be the same as that developed in the conduit ; the injection of the sulfide into the country rocks likely occurred before formation of monosulfide solid solution.The Ovoid Deposit is characterized by coarse-grained loop-textured ores consisting of 10cm-2msized pyrrhotite crystals separated by chalcopyrite and pentlandite.A small lens of massive cubanite surrounded by more magnetite-rich sulfide assemblages represents what appears to be the product of in-situ sulfide fractionation. Detailed exploration in the area between the Reid Brook Zone and the Eastern Deeps has shown that these intrusions and ore deposits are connected by a branched dyke and chamber system in a major westeast fault zone.The Eastern Deeps chamber may be controlled by graben-like fault structures , and the marginal structures appear to have controlled dykes which connect the chambers at different levels in the crust.The geological relationships in the intrusion are consistent with emplacement of the silicate and sulfide laden magma from a deeper sub-chamber (possibly a deep eastward extension of the Western Deeps Intrusion where S-saturation was initially achieved) .The silicate and sulfide magmas were likely emplaced through this conduit into the Eastern Deeps intrusion as a number of different fragment laden pulses of sulfide-silicate melt that evolved with different R factors and in response to some variation in the degree of evolution of the parental magma.S isotope and S/Se data coupled with geological evidence point to a crustal source for the sulfur , and the site of equilibration of mafic magma and crustal S is placed at depth in a sulfidic Tasiuyak Gneiss. The structural control on emplacement of small intrusions with transported sulfide is a feature found in different nickel sulfide deposits around the world.Champagne glass-shaped openings in sub-vertical chonoliths are a common morphology for this deposit type (e.g.the Jinchuan , Huangshan , Huangshandong , Jingbulake , Limahe , Hong Qi Ling deposits in China , the Eagle deposits in the United States , and the Double Eagle deposit in Canada) .Some of the structures of the Midcontinent Rift of North America also host Ni-Cu-(PGE) deposits of this type (e.g.the Current Lake Complex in the Quetico Fault Zone in Ontario , Canada and the Tamarac mineralisation in the Great Lakes Structural Zone of the United States) .Other major nickel deposits associated with flat structures adjacent to major mantle-penetrating structures include the Noril'sk , Noril'sk II , Kharaelakh , NW Talnakh , and NE Talnakh Intrusions of the Noril'sk Region of Russia , the Kalatongke deposit in NW China , and Babel-Nebo in Western Australia.These deposits are all formed in mantle-penetrating structural conduits that link into the roots of large igneous provinces near the edges of old cratons. | Peter C.Lightfoot Dawn Evans-Lamswood Robert Wheeler | 2012 | 西北地质2012，45，4： | 3 |
| 9 | Climate Change Modelling and Its Roles to Chinese Crops Yield显示文摘Climate has been changing in the last fifty years in China and will continue to change regardless any efforts for mitigation.Agriculture is a climate-dependent activity and highly sensitive to climate changes and climate variability.Understanding the interactions between climate change and agricultural production is essential for society stable development of China.The first mission is to fully understand how to predict future climate and link it with agriculture production system.In this paper,recent studies both domestic and international are reviewed in order to provide an overall image of the progress in climate change researches.The methods for climate change scenarios construction are introduced.The pivotal techniques linking crop model and climate models are systematically assessed and climate change impacts on Chinese crops yield among model results are summarized.The study found that simulated productions of grain crop inherit uncertainty from using different climate models,emission scenarios and the crops simulation models.Moreover,studies have different spatial resolutions,and methods for general circulation model(GCM) downscaling which increase the uncertainty for regional impacts assessment.However,the magnitude of change in crop production due to climate change(at 700 ppm CO2 eq correct) appears within ±10% for China in these assessments.In most literatures,the three cereal crop yields showed decline under climate change scenarios and only wheat in some region showed increase.Finally,the paper points out several gaps in current researches which need more studies to shorten the distance for objective recognizing the impacts of climate change on crops.The uncertainty for crop yield projection is associated with climate change scenarios,CO2 fertilization effects and adaptation options.Therefore,more studies on the fields such as free air CO 2 enrichment experiment and practical adaptations implemented need to be carried out. | JU Hui LIN Er-da Tim Wheeler Andrew Challinor JIANG Shuai | 2013 | Journal of Integrative Agriculture2013，12，5： | 3 |
| 10 | Iterative coupling reservoir simulation on high performance computers显示文摘In this paper,the iterative coupling approach is proposed for applications to solving multiphase flow equation systems in reservoir simulation,as it provides a more flexible time-stepping strategy than existing approaches.The iterative method decouples the whole equation systems into pressure and saturation/concentration equations,and then solves them in sequence,implicitly and semi-implicitly.At each time step,a series of iterations are computed,which involve solving linearized equations using specific tolerances that are iteration dependent.Following convergence of subproblems,material balance is checked.Convergence of time steps is based on material balance errors.Key components of the iterative method include phase scaling for deriving a pressure equation and use of several advanced numerical techniques.The iterative model is implemented for parallel computing platforms and shows high parallel efficiency and scalability. | Lu Bo Wheeler Mary F. | 2009 | Petroleum Science2009，6，1： | 2 |
| 11 | Financial incentives and endogenous enforcement in China’s pollution levy system显示文摘 | Hua Wang David Wheeler | 2004 | Journal of Environmental Economics and Management2004，，1： | 2 |
| 12 | Cotton Gh BAK 1 Mediates Verticillium Wilt Resistance and Cell Death显示文摘 | Xiquan Gao Fangjun Li Maoying Li Ali S. Kianinejad Jane K. Dever Terry A. Wheeler Zhaohu Li Ping He Libo Shan | 2013 | J Integr Plant Biol2013，，7： | 2 |
| 13 | Randomised clinical trial: the safety and tolerability of T richuris suis ova in patients with Crohn’s disease显示文摘 | W. J. Sandborn D. E. Elliott J. Weinstock R. W. Summers A. Landry‐Wheeler N. Silver M. D. Harnett S. B. Hanauer | 2013 | Aliment Pharmacol Ther2013，，3： | 2 |
| 14 | In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics显示文摘 | Michael A. Bonaguidi Michael A. Wheeler Jason S. Shapiro Ryan P. Stadel Gerald J. Sun Guo-li Ming Hongjun Song | 2011 | Cell2011，，7： | 2 |
| 15 | Prosthetic above-knee femoropopliteal bypass grafting: Five-year results of a randomized trial显示文摘 | Richard M Green William M Abbott Teruo Matsumoto Jock R Wheeler Normand Miller Frank J Veith Sam Money H Edward Garrett | 2000 | Journal of Vascular Surgery2000，，： | 2 |
| 16 | Bridge无家可归者援助中心显示文摘在德克萨斯州内陆,当前的星星都较之前闪亮。这要归功于利他主义和赋予妇女权力的愿望:"桥"——一幢漂亮的耗资1700万美元的现代结构($2152sq mt/$200sf)——这项工程提升了达拉斯的形象。这幢充满温情的无家可归者援助中心是2010年德克萨斯州年度建筑的标杆:由位于圣安东尼奥的Overland合伙建筑师事务所设计,并由达拉斯当地的Camargo Copeland负责现场监理。 | Bradley Wheeler Sigma Ning Charles Davis Smith | 2011 | 中外建筑2011，，9： | 2 |
| 17 | High Voltage High Frequency Power Transformer for Pulsed Power Applications显示文摘 | T. Filchev A. Watson J. Clare P. Wheeler F. Carastro | 2011 | Journal of Energy and Power Engineering2011，5，10： | 2 |
| 18 | Acute lung injury and the acute respiratory distress syndrome: a clinical review显示文摘 | Arthur P Wheeler Gordon R Bernard | 2007 | 2007 (9572)2007，，9572： | 2 |
| 19 | Factors Related to Inflammation of the Ovarian Epithelium and Risk of Ovarian Cancer显示文摘 | Roberta B. Ness Jeane Ann Grisso Carrie Cottreau Jennifer Klapper Ron Vergona James E. Wheeler Mark Morgan James J. Schlesselman | 2000 | Epidemiology2000，，2： | 2 |
| 20 | The Effect of pH and Plaque on the Uptake of Cu and Mn in Phragmites australis (Cav.) Trin ex. Steudel显示文摘 | L.C. Batty A.J.M. Baker B.D. Wheeler C.D. Curtis | 2000 | Annals of Botany2000，，3： | 2 |
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