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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Preventing Burnout in Mental Health Workers at Interpersonal Level : An Italian Pilot stuay 显示文摘 | Scamem P Bosco A Soleti E | 2009 | Community Ment Health J2009，45，： | 1 |
| 3 | Sequential kidney/islet transplantation:efficacy and safety assessment of a steroid-free immunosuppression protocol显示文摘 | Toso C Baertschiger R Morel P Bosco D Armanet M Wojtusciszyn A | | 0，，： | 1 |
| 4 | Ovulating induction methods in rabbit does:the pituitary and ovarian responses显示文摘 | Rebollar P.G Dal Bosco A Millàn P | | 0，，： | 1 |
| 5 | Audiogenic seizures susceptibility in transgemic mice with fragile X syndrome 显示文摘 | Musumeci S A Bosco P Colabrese G | 2000 | Epilepsia2000，41，： | 1 |
| 6 | Pharmacokinet- ics of a novel submicron budesonide dispersion for nebulized de- livery in asthma 显示文摘 | SHREWSBURY S B BOSCO A P USTER P S | 2009 | Int J Pharm2009，365，12： | 1 |
| 7 | A Nationwide Comparison of Driving Distance Versus Straight-Line Distance to Hospitals显示文摘 | Boscoe F P Henry K A Zdeb M S | 2012 | The Professional Geographer2012，64，20： | 1 |
| 8 | Relationships of the Sardinian isolate of tomato yellow leaf curl geminivrus with its whitefly vector Bemisia tabaci Gen显示文摘 | Caciagli P Bosco D Lina A B | 1995 | Eur J Plant Pathol1995，101，： | 1 |
| 9 | Perioperative strategies for decreasing infection:a comprehensive evidence-based approach显示文摘 | Bosco J A 3rd Slover J D Haas J P | 2010 | Instr Course Lect2010，59，： | 1 |
| 10 | Cryptogenic cerebral infarction in a young patient with very high lipoprotein(a) serum level as the only risk factor 显示文摘 | Lentini A Fornengo P Bosco G | 2007 | Neurol Sci2007，28，1： | 1 |
| 11 | Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast显示文摘 | Sapino A Bosco M Cassoni P | 2006 | Mod Pathol2006，19，4： | 1 |
| 12 | Two CD34+ stem cells fromumbilical cord blood enrichment method显示文摘 | Pafumi Bosco P Cavallaro A | 2002 | Pediatr Hematol On-col2002，19，4： | 1 |
| 13 | Small molecule oxidation products trigger disease associated protein misfolding显示文摘 | Bieschke J Zhang Q Bosco D A Lerner R A Powers E T Wentworth P Jr | 2006 | Acc Chem Res2006，39，： | 1 |
| 14 | Elevated levels of oxidized cholesterol metabo lites in Lewy body disease brains accelerate alpha synuclein fibrilization显示文摘 | Bosco D A Fowler D M Zhang Q Nieva J Powers E T Wentworth P Jr | 2006 | Nat Chem Biol2006，2，： | 1 |
| 15 | Two CD34+stem cells fromumbilical cord blood enrichment methods显示文摘 | Pafumi C Bosco P Cavallaro A | 2002 | Pediatr HematolOncol2002，19，4： | 1 |
| 16 | Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast显示文摘 | Sapino A Bosco M Cassoni P | 2006 | Mod Pathol2006，19，4： | 1 |
| 17 | Prevalence of methylenetetrahydrofolate reduetase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations 显示文摘 | Gueant- Rodriguez RM Gueant JL Debard R Thirion S Hong LX Bronowicki JP Namour F Chabi NW Sanni A Anello G Bosco P Romano C Amouzou E Arrieta HR Sanehez BE Romano A Herbeth B Guilhnd JC Mutchlnick OM | 2006 | Am J Clin Nutr2006，84，5： | 1 |
| 18 | Stress fractures and stress reactions of the diaphyseal femur in collegiate athletes: an analysis of 25 cases 显示文摘 | KOENIG S J TOTH A P BOSCO J A | 2008 | Am J Orthop (Belle Mead NJ)2008，37，47： | 1 |
| 19 | Minimum reinforcement in high-strength concrete显示文摘 | BOSCO C CARPINTERI A DEBERNARDI P G | 1990 | Journal of Engineering Mechanics1990，11，6： | 1 |
| 20 | Effect of mild hypothermic cardiopulmonary bypass on the amplitude of somatosensory-evoked potentials显示文摘 | Zanatta P Bosco E Comin A | 2014 | J Neurosurg Anesthesiol2014，26，2： | 1 |
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