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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Neurokinin 1 receptor expression and substance P physiological actions are developmentally regulated in the rabbit retina显示文摘 | Casini G Dal Monte M Fornai F Bosco L Willems D Yang Q | 2004 | Neuroscience2004，124，1： | 1 |
| 3 | Posterior lumbar fusion by peek rods in degenerative spine preliminary report on 30 cases显示文摘 | F De Iure G Bosco M Cappuccio | 2012 | EurSpineJ2012，，1： | 1 |
| 4 | A Nationwide Comparison of Driving Distance Versus Straight-Line Distance to Hospitals显示文摘 | Boscoe F P Henry K A Zdeb M S | 2012 | The Professional Geographer2012，64，20： | 1 |
| 5 | Use of progestagen-gonadotrophin treatments in estrus synchronization of sheep 显示文摘 | Boscos C M Samartzi F C Dellis S | 2002 | Theriogenology2002，58，7： | 1 |
| 6 | Development of a rapid LC - DAD/FLD method for the simultaneous determination of auxins and absclsic acid in plant extracts显示文摘 | Bosco R Caser M Vanara F | 2013 | Journal of Agricultural and Food Chemistry2013，61，10： | 1 |
| 7 | Use of pro- gestagen-gonadotrophin treatments in estrus synchro- nization of sheep 显示文摘 | Boscos C M Samartzi F C Dellis S | 2002 | Theriogenology2002，58，7： | 1 |
| 8 | The funda- mental context categories in understanding communicative intention 显示文摘 | BOSCO F M M BucciareUi B G Bara | 2004 | Journal of Pragmatics2004，，40： | 1 |
| 9 | Cytologic features of metanephric adenoma of the kidney during pregnancy:a case report显示文摘 | Bosco M Galliano D La Saponara F | | 0，，03： | 1 |
| 10 | Use of progestagen-gonadortophin treatments in estrus synchronization of sheep 显示文摘 | Boscos C M Samartzi F C Dellis S | 2002 | Theriogenology2002，58，7： | 1 |
| 11 | A technology-assisted learning setup as assessment supplement for three persons with a diagnosis of post-coma vegetative state and pervasive motor impairment显示文摘 | Lancioni GE Singh NN O'Reilly MF Sigafoos J Buonocunto F Sacco V Colonna F Navarro J Lanzilotti C Bosco A Megan G De tommaso M | 2009 | Res Dev Disabil2009，30，： | 1 |
| 12 | Posterior lumbar fusion by peek rods in degenerative spine: preliminary report on 30 cases显示文摘 | de Iure F Bosco G Cappuccio M | 2012 | Eur Spine J2012，21，1： | 1 |
| 13 | Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993-2002显示文摘 | Boscoe F P Schymura M J | 2006 | BMC Cancer2006，6，： | 1 |
| 14 | Use of progestin -gonadotropin treatments in estrus synchronization of sheep 显示文摘 | BOSCOS C M SAMARTZI F C DELLIS S | 2002 | Theriogenology2002，58，7： | 1 |
| 15 | The hypoxic synovial environment regulates expression of vascular endothelial growth factor and osteopontin in juvenile idiopathic arthritis显示文摘 | BOSCO M C DELFINO S FERLITO F | 2009 | J Rheumatol2009，36，6： | 1 |
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