|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The versatile functions of Sox9 in development,stem cells,and human diseases显示文摘The transcription factor Sox9 was first discovered in patients with campomelic dysplasia,a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis.Since then,its role as a cell fate determiner during embryonic development has been well characterized;Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs.However,recent data has shown that ectoderm-and endoderm-derived tissues continue to express Sox9 in mature organs and stem cell pools,suggesting its role in cell maintenance and specification during adult life.The versatility of Sox9 may be explained by a combination of posttranscriptional modifications,binding partners,and the tissue type in which it is expressed.Considering its importance during both development and adult life,it follows that dysregulation of Sox9 has been implicated in various congenital and acquired diseases,including fibrosis and cancer.This review provides a summary of the various roles of Sox9 in cell fate specification,stem cell biology,and related human diseases.Ultimately,understanding the mechanisms that regulate Sox9 will be crucial for developing effective therapies to treat disease caused by stem cell dysregulation or even reverse organ damage. | Alice Jo Sahitya Denduluri Bosi Zhang Zhongliang Wang Liangjun Yin Zhengjian Yan Richard Kang Lewis L.Shi James Mok Michael J.Lee Rex C.Haydon | 2014 | Genes & Diseases2014，1，2： | 16 |
| 2 | Metabolomics characterization of colostrum in three sow breeds and its influences on piglets' survival and litter growth rates显示文摘Background: Colostrum is the first secretion produced by mammary glands during the hours immediately preceding and succeeding parturition. This secretion differs from milk and represents an essential vehicle of passive immunity,prebiotic compounds and growth factors involved in intestinal development. Most of the literature concerning colostrum composition refers mainly to human and cow; and little is known about pig colostrum metabolome and how it varies between pig breeds and different farrowing parity. Thus, the aim of the present research is to provide new information about pig colostrum composition and the associations between metabolites, the sows' breed and the survival and growth rates of their litters.Results: Colostrum samples were gathered from 58 parturitions of sows belonging to three different breeds chosen for their importance in Italian heavy pig production: 31 Large White, 15 Landrace and 12 Duroc respectively. The defatted and ultrafiltered colostrum samples were analysed using1 H–NMR spectroscopy. Principal Components Analysis(PCA) was assessed on the obtained spectra. In addition, using a Stepwise Regression and a Linear Regression analyses the metabolites named after the signals assignment were tested for their associations with piglets' performances.Twenty-five metabolites were identified, comprehending monosaccharides, disaccharides(such as lactose), organic acids(lactate, citrate, acetate and formate), nitrogenous organic acids(such as creatine) and other compounds,including nucleotides. PCA results evidence a clustering due to breed and season effects. Lactose was the main compound determining the assignment of the samples into different clusters according to the sow breed. Furthermore, some metabolites showed to be associated with piglets' performance and survival traits: acetate and taurine were positively related to litter weight gain and piglets' survival rate, respectively, while dimethylamine and cis-aconitate were linked to new-borns' impaired ability to survive.Conclusions: The results obtained suggest that colostrum composition is affected by breed, which, together with environmental conditions, may cause changes in colostrum metabolites content with possible consequences on piglets' performances. Among the identified metabolites, acetate, taurine, dimethylamine and cis-aconitate showed consistent associations with piglets' survival rate and litter weight gain, implying that these compounds may affect new-borns' ability to survive. | Gianfranco Picone Martina Zappaterra Diana Luise Alessia Trimigno Francesco Capozzi Vincenzo Motta Roberta Davoli Leonardo Nanni Costa Paolo Bosi Paolo Trevisi | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 6 |
| 3 | CNT@MnO_(2) composite ink toward a flexible 3D printed micro-zinc-ion battery显示文摘Flexible energy storage devices have played a significant role in multiscenario applications,while flexible zinc-ion batteries(ZIBs),as an essential branch,have developed rapidly in recent years.Three-dimensional(3D)printing is an extremely advanced technology to design and modify the structure of batteries and provides unlimited possibilities for the diversified development of energy storage equipment.Herein,by utilizing 3D printing technology,carbon nanotube(CNT)is coated by MnO_(2) to form a flexible CNT@MnO_(2) ink as a cathode for flexible aqueous micro-ZIBs for the first time and zinc powder ink is used as an anode due to its high flexibility and bendability.The Zn//CNT@MnO_(2) flexible battery shows a stable capacity of 63μAh cm^(−2) at 0.4mA cm^(−2).When the battery is bent in different states,the maximum capacity loss compared with the initial value is only 2.72%,indicating its stability.This study shows the potential of 3D printing technology in the development of flexible manganese-based ZIBs. | Yujin Ren Fanbo Meng Siwen Zhang Bu Ping Hui Li Bosi Yin Tianyi Ma | 2022 | Carbon Energy2022，4，3： | 5 |
| 4 | Zinc Anode for Mild Aqueous Zinc-Ion Batteries: Challenges, Strategies, and Perspectives显示文摘The rapid advance of mild aqueous zinc-ion batteries(ZIBs)is driving the development of the energy storage system market.But the thorny issues of Zn anodes,mainly including dendrite growth,hydrogen evolution,and corrosion,severely reduce the performance of ZIBs.To commercialize ZIBs,researchers must overcome formidable challenges.Research about mild aqueous ZIBs is still developing.Various technical and scientific obstacles to designing Zn anodes with high stripping efficiency and long cycling life have not been resolved.Moreover,the performance of Zn anodes is a complex scientific issue determined by various parameters,most of which are often ignored,failing to achieve the maximum performance of the cell.This review proposes a comprehensive overview of existing Zn anode issues and the corresponding strategies,frontiers,and development trends to deeply comprehend the essence and inner connection of degradation mechanism and performance.First,the formation mechanism of dendrite growth,hydrogen evolution,corrosion,and their influence on the anode are analyzed.Furthermore,various strategies for constructing stable Zn anodes are summarized and discussed in detail from multiple perspectives.These strategies are mainly divided into interface modification,structural anode,alloying anode,intercalation anode,liquid electrolyte,non-liquid electrolyte,separator design,and other strategies.Finally,research directions and prospects are put forward for Zn anodes.This contribution highlights the latest developments and provides new insights into the advanced Zn anode for future research. | Jinzhang Yang Bosi Yin Ying Sun Hongge Pan Wenping Sun Baohua Jia Siwen Zhang Tianyi Ma | 2022 | Nano-Micro Letters2022，14，3： | 5 |
| 5 | Methodology and application of Escherichia coli F4 and F18 encoding infection models in post-weaning pigs显示文摘The enterotoxigenic Escherichia coli (ETEC) expressing F4 and F18 fimbriae are the two main pathogens associated with post-weaning diarrhea (PWD) in piglets.The growing global concern regarding antimicrobial resistance (AMR) has encouraged research into the development of nutritional and feeding strategies as well as vaccination protocols in order to counteract the PWD due to ETEC.A valid approach to researching effective strategies is to implement piglet in vivo challenge models with ETEC infection.Thus,the proper application and standardization of ETEC F4 and F18 challenge models represent an urgent priority.The current review provides an overview regarding the current piglet ETEC F4 and F18 challenge models;it highlights the key points for setting the challenge protocols and the most important indicators which should be included in research studies to verify the effectiveness of the ETEC challenge.Based on the current review,it is recommended that the setting of the model correctly assesses the choice and preconditioning of pigs,and the timing and dosage of the ETEC inoculation.Furthermore,the evaluation of the ETEC challenge response should include both clinical parameters (such as the occurrence of diarrhea,rectal temperature and bacterial fecal shedding) and biomarkers for the specific expression of ETEC F4/F18 (such as antibody production,specific F4/F18 immunoglobulins (lgs),ETEC F4/F18 fecal enumeration and analysis of the F4/F18 receptors expression in the intestinal brush borders).On the basis of the review,the piglets' response upon F4 or F18 inoculation differed in terms of the timing and intensity of the diarrhea development,on ETEC fecal shedding and in the piglets' immunological antibody response.This information was considered to be relevant to correctly define the experimental protocol,the data recording and the sample collections.Appropriate challenge settings and evaluation of the response parameters will allow future research studies to comply with the replacement,reduction and refinement (3R) approach,and to be able to evaluate the efficiency of a given feeding,nutritional or vaccination intervention in order to combat ETEC infection. | Diana Luise Charlotte Lauridsen Paolo Bosi Paolo Trevisi | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 4 |
| 6 | Bi_(2)S_(3) for Aqueous Zn Ion Battery with Enhanced Cycle Stability显示文摘Aqueous Zn ion batteries(ZIBs)are promising in energy storage due to the low cost,high safety,and material abundance.The development of metal oxides as the cathode for ZIBs is limited by the strong electrostatic forces between O2−and Zn2+which leads to poor cyclic stability.Herein,Bi2S3 is proposed as a promising cathode material for rechargeable aqueous ZIBs.Improved cyclic stability and fast diffusion of Zn2+is observed.Also,the layered structure of Bi2S3 with the weak van der Waals interaction between layers offers paths for diffusion and occupancy of Zn2+.As a result,the Zn/Bi2S3 battery delivers high capacity of 161 mAh g−1 at 0.2 A g−1 and good cycling stability up to 100 cycles with ca.100%retention.The battery also demonstrates good cyclic performance of ca.80.3%over 2000 cycles at 1 A g−1.The storage mechanism in the Bi2S3 cathode is related to the reversible Zn ion intercalation/extraction reactions and the capacitive contribution.This work indicates that Bi2S3 shows great potential as the cathode of ZIBs with good performance and stability. | Ting Xiong Yinming Wang Bosi Yin Wen Shi Wee Siang Vincent Lee Junmin Xue | 2020 | Nano-Micro Letters2020，12，1： | 3 |
| 7 | CNN-Based Fast HEVC Quantization Parameter Mode Decision显示文摘With the development of multimedia presentation technology,image acquisition technology and the Internet industry,long-distance communication methods have changed from the previous letter,the audio to the current audio/video.And the proportion of video in work,study and entertainment keeps increasing,high-definition video is getting more and more attention.Due to the limits of the network environment and storage capacity,the original video must be encoded to be efficiently transmitted and stored.High Efficient Video Coding(HEVC)requires a large amount of time to recursively traverse all possible quantization parameter values of the coding unit in the adaptive quantization process.The optimal quantization parameter is calculated by comparing the rate distortion cost.In this paper,we propose a fast decision method for HEVC quantization parameters selection based on convolutional neural network,which saves video’s encoding time. | Liming Chen Bosi Wang Weijie Yu Xu Fan | 2019 | Journal of New Media2019，1，3： | 2 |
| 8 | Phase angle from bioelectrical impedance analysis: population reference values by age, sex, and body mass index 显示文摘 | Bosy Westphal A Danielzik S Dorhofer RP | 2006 | JPEN J Parenter Enteral Nutr2006，30，4： | 1 |
| 9 | Effects of dietary buffering characteristic and protected or unprotected acids on piglet growth, digestibility and characteristics of gut content显示文摘 | BOSI P JUNG H J HAN I K | 1999 | Asian Aust J Anim Sci1999，12，7： | 1 |
| 10 | Human metapneumovirus and lower respiratory tract disease in children 显示文摘 | Pricinpi N Esposito S Bosis S | 2004 | N Engl J Med2004，350，17： | 1 |
| 11 | ICA12(SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical type I diabetes显示文摘 | Lampasona V Scirpoli M Bosi E | 2001 | Diabetologia2001，44，2： | 1 |
| 12 | Synthesis of Thioether Phosphocholine Analogues显示文摘 | Dieter B J Herrmann Uwe Bicker | 1987 | Lipids1987，22，： | 1 |
| 13 | Characterization of NMDA receptor subunit-specific antibodies: Distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum 显示文摘 | Wang Y Bosy T Z Yasuda R P | 1995 | J Neurochem1995，65，1： | 1 |
| 14 | Temporal variability in birth prevalence of congenital heart defects as recorded by a general birth de- fects registry显示文摘 | Bosi G Garani G Scorrano M | 2003 | J Pediatr2003，142，6： | 1 |
| 15 | ISO/IEC MPEG-2Advanced Audio Aoding显示文摘 | Bosi M Brandenburg K Quackenbush S | 1997 | Journal of the Audio Engineering Society1997，45，10： | 1 |
| 16 | Role of atypical bacteria and azithromycin therapy for children with recurrent respiratory tract infections显示文摘 | Esposito S Bosis S Faelli N | 2005 | Pediatr Infect Dis J2005，24，5： | 1 |
| 17 | Ontogeny of NMDAR , subnit protein expression in five region of rat brain 显示文摘 | Luo JH Bosy TZ Wang Y | 1996 | Brain Res Dev Brain Res1996，2992，1： | 1 |
| 18 | A etiology of acute pharyngitis: The role of atypical bacteria 显示文摘 | Esposito S BlasiF Bosis S | 2004 | J Med Microbiol2004，53，7： | 1 |
| 19 | The influence of fat protection of calcium formate on growth and intestinal defence in Escherichia coli K88+ challenged weanling pigs 显示文摘 | Bosi P Sarli G Casini L | 2007 | Anita Feed Sci Technol2007，116，： | 1 |
| 20 | Role of respiratory pathogens in infants hospitalized for a first episode of wheezing and their impact on recurrences显示文摘 | Bosis S Esposito S Niesters HG | | 0，，07： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员