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| 1 | Clinicopathological classification and individualized treatment of breast cancer显示文摘 | Hu Hui Liu Yin-hua Xu Ling Zhao Jian-xin Duan Xue-ning Ye Jing-ming Li Ting Zhang Hong Zhang Shuang Xiong Yan | 2013 | Chinese Medical Journal2013，，20： | 8 |
| 2 | Investigation of benzylisoquinoline alkaloid biosynthetic pathway and its transcriptional regulation in lotus显示文摘Lotus predominantly accumulates benzylisoquinoline alkaloids(BIAs),but their biosynthesis and regulation remain unclear.Here,we investigated structural and regulatory genes involved in BIA accumulation in lotus.Two clustered CYP80 genes were identified to be responsible for the biosynthesis of bis-BIAs and aporphine-type BIAs,respectively,and their tissue-specific expression causes divergence in alkaloid component between leaf and embryo.In contrast with the common(S)-reticuline precursor for most BIAs,aporphine alkaloids in lotus leaf may result from the(S)-N-methylcoclaurine precursor.Structural diversity of BIA alkaloids in the leaf is attributed to enzymatic modifications,including intramolecular C–C phenol coupling on ring A and methylation and demethylation at certain positions.Additionally,most BIA biosynthetic pathway genes show higher levels of expression in the leaf of high-BIA cultivar compared with low-BIA cultivar,suggesting transcriptional regulation of BIA accumulation in lotus.Five transcription factors,including three MYBs,one ethylene-responsive factor,and one basic helix–loop–helix(bHLH),were identified to be candidate regulators of BIA biosynthesis in lotus.Our study reveals a BIA biosynthetic pathway and its transcriptional regulation in lotus,which will enable a deeper understanding of BIA biosynthesis in plants. | Xianbao Deng Li Zhao Ting Fang Yaqian Xiong Collins Ogutu Dong Yang Sornkanok Vimolmangkang Yanling Liu Yuepeng Han | 2018 | Horticulture Research2018，5，1： | 8 |
| 3 | Co3(hexahydroxytriphenylene)2:A conductive metal-organic framework for ambient electrocatalytic N2 reduction to NH3显示文摘As a carbon-neutral alternative to the Haber-Bosch process,electrochemical N2 reduction enables environment-friendly NH3 synthesis at ambient conditions but needs active electrocatalysts for the N2 reduction reaction.Here,we report that conductive metal-organic framework CO3(hexahydroxytriphenylene)2(Co3 HHTP2)nanoparticles act as an efficient catalyst for ambient electrochemical N2-to-NH3 fixation.When tested in 0.5 M LiClO4,such Co3 HHTP2 achieves a large NH3 yield of 22.14μg·h^-1·mg^-1 cat.with a faradaic efficiency of 3.34%at-0.40 V versus the reversible hydrogen electrode.This catalyst also shows high electrochemical stability and excellent selectivity toward NH3 synthesis. | Wei Xiong Xin Cheng Ting Wang Yongsong Luo Jing Feng Siyu Lu Abdullah M.Asiri Wei Li Zhenju Jiang Xuping Sun | 2020 | Nano Research2020，13，4： | 7 |
| 4 | OsGRAS19 May Be a Novel Component Involved in the Brassinosteroid Signaling Pathway in Rice显示文摘 | LishengChen Guosheng Xiong Xia Cui Meixian Yan Ting Xu Qian Qian Yongbiao Xue Jiayang Li Yonghong Wang | 2013 | Molecular Plant2013，6，3： | 6 |
| 5 | Association of Platelet-Activating Factor Receptor Gene rs5938(G/T) and rs313152(T/C) Polymorphisms with Coronary Heart Disease and Blood Stasis Syndrome in A Chinese Han Population显示文摘Objective: To explore the association of the platelet-activating factor receptor(PAFR) gene rs5938, rs313152 and rs76744145 polymorphisms with coronary heart disease(CHD) and blood stasis syndrome(BSS) of CHD in Chinese Han population. Methods: A total of 570 CHD patients(299 with BSS and 271 with non-BSS) and 317 controls were enrolled. The PAFR gene rs5938, rs313152 and rs76744145 polymorphisms were genotyped using the multiplex SNaP shot technology. The statistical analysis was conducted using a multiple variable logistic regression model. Results: Significant differences were detected in the genotypes frequency distributions of the rs5938(P<0.01), but not the rs313152(P>0.05), between the controls and CHD patients. Individuals with an rs5938 or rs313152 mutated allele had a low risk for CHD [adjusted odds ratio(aOR)=0.35, 95% confidence interval(CI): 0.23 to 0.56, P<0.01; aOR=0.65, 95% CI: 0.46 to 0.91, P<0.05, respectively]. After the CHD patients were stratified as BSS or non-BSS according to their Chinese medicine patterns, the rs5938 polymorphism mutated alleles had a significant association with a low risk for BSS of CHD(aOR=0.32, 95% CI: 0.18 to 0.57, P<0.01) and non-BSS of CHD(aOR=0.31, 95% CI: 0.17 to 0.55, P<0.01). The rs313152 polymorphism was associated with a low risk for BSS(aOR=0.51, 95% CI: 0.33 to 0.79, P<0.01), but not for non-BSS(aOR=1.22, 95% CI: 0.81 to 1.85, P>0.05). Furthermore, the interaction effect of the rs5938 and rs313152 polymorphisms for BSS of CHD was significantly based on an aOR value associated with the combination of the rs5938 GT genotype with the rs313152 TC genotype of 0.27(95% CI: 0.1 to 0.7, P<0.01). Conclusion: The PAFR gene rs5938 or rs313152 polymorphisms might be a potential biomarker for susceptibility to CHD, especially to BSS of CHD in Chinese Han population. | ZHENG Guo-hua XIONG Shang-quan CHEN Hai-ying MEI Li-juan WANG Ting | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 6 |
| 6 | High He-ion irradiation resistance of CrMnFeCoNi high-entropy alloy revealed by comparison study with Ni and 304SS显示文摘High entropy alloys(HEAs) have presented potential applications in nuclear power plants owing to their novel atomic structure based high irradiation resistance. However, understanding of He-ion irradiation of HEAs is still lacking. In this work, we reveal He-ion irradiation resistance of HEA CrMnFeCoNi by comparison study with a pure Ni and a 304 stainless steel(304SS). It is found that the damage structure in the three materials can be characterized with He bubbles and stacking faults/stacking fault tetrahedrons((SFs/SFTs), which show a similar depth distribution after He-ion irradiation at both RT and 450℃.Although the He bubbles have a similar size about 2nm after irradiation at RT, the He bubble sizes of the HEA, 304SS, and Ni increase to 4.0±0.9,5.3±1.0 and 6.7 ±1.0 nm after irradiation at 450℃, respectively. Moreover, the density of SFs/SFTs displays in an order of Ni < 304 SS < HEA at both RT and 450℃.The He-ion irradiation at RT causes significant hardness enhancement for the three materials, however,compared to RT, after irradiation at 450℃, the Ni presents softening, while the 304SS, especially the HEA,shows further hardening. Thus, the HEA CrMnFeCoNi possesses the smallest He bubble size, the densest SFs/SFTs, and the highest hardening, indicating the best structural stability, as well as the best He-ion irradiation resistance, which can be attributed to its low mobility of He atoms and point defects. | Lixin Yang Hualong Ge Jian Zhang Ting Xiong Qianqian Jin Yangtao Zhou Xiaohong Shao Bo Zhang Zhengwang Zhu Shijian Zheng Xiuliang Ma | 2019 | Journal of Materials Science & Technology2019，35，3： | 5 |
| 7 | Small molecules in targeted cancer therapy:advances,challenges,and future perspectives显示文摘Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,targeted therapeutic drugs have become mainstream cancer treatments.Since the first tyrosine kinase inhibitor imatinib was approved to enter the market by the US Food and Drug Administration(FDA)in 2001,an increasing number of small-molecule targeted drugs have been developed for the treatment of malignancies.By December 2020,89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration(NMPA)of China.Despite great progress,small-molecule targeted anti-cancer drugs still face many challenges,such as a low response rate and drug resistance.To better promote the development of targeted anti-cancer drugs,we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification.We present all the approved drugs as well as important drug candidates in clinical trials for each target,discuss the current challenges,and provide insights and perspectives for the research and development of anti-cancer drugs. | Lei Zhong Yueshan Li Liang Xiong Wenjing Wang Ming Wu Ting Yuan Wei Yang Chenyu Tian Zhuang Miao Tianqi Wang Shengyong Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 5 |
| 8 | Rice allelopathy and its properties of molecular ecology显示文摘Crop allelopathy is a promising and environmentally friendly method in weed control;however,the inducible genetic trait for allelopathy in the suppression of weeds needs to be overcome for practical use.Further study needs to be directed to this end to elucidate the molecular genetics and its physiologic mechanism.In this paper,the authors review recent advances in the investigation of rice allelopathy and its molecular regulatory mechanism,especially in responses to stressful conditions including biotic and abiotic factors in China.Previous studies show that rice allelopathy could be enhanced when the rice accession was exposed to stressful conditions,and further analysis by the transcriptomics and proteomics approaches conducted in our laboratory indicated that the increase in allelopathic potential of rice,when exposed to the stresses,was attributed to increased expression level of genes involved in phenolic synthetic metabolism.The increasing phenolic compounds have been confirmed as the main allelochemicals and they jointly act to suppress the target,especially in responses to stressful condition,but it seems to be the primary effect in phenolic allelopathy.We still wonder how the exudates from rice root,which were released into rhizosphere soil,are transformed by soil microorganism to produce the higher secondary effect of phenolic allelopathy in the suppression of weeds.Therefore,the authors suggest that rhizosphere biologic properties of allelopathy in rice and its mechanism are being the key research areas in the world now,and systems biology and its approaches,such as metagenomics and metaproteomics,would be helpful to reveal the process and its molecular ecological mechanism regarding rhizospheric biology of rice allelopathy. | Wenxiong LIN Changxun FANG Ting CHEN Ruiyu LIN Jun XIONG Haibin WANG | 2010 | Frontiers in Biology2010，5，3： | 5 |
| 9 | Isolation, identification and arsenic-resistance of Acidithiobacillus ferrooxidans HX3 producing schwertmannite显示文摘Schwertmannite, a ubiquitous mineral present in iron oxyhydroxides formed in iron- and sulfate-rich acid media, favors incorporation of some toxic anions in its structure. We reported an iron-oxidizing bacterial strain HX3 from a municipal sludge that facilitates the formation of pure schwertmannite in cultures. Ferrous iron oxidation by the isolated strain HX3 was optimum at an initial pH of 2.0–3.3 and temperature of 28–35°C. Pure schwertmannite was found through bacterial oxidation of ferrous iron at an initial pH 2.8and temperature 28°C. Following 16 S rDNA gene sequence analysis the bacterial strain HX3 was identified as Acidithiobacillus ferrooxidans. The arsenic-resistance A. ferrooxidans HX3 showed the potential of environmental application in arsenic removal from the As(III)- and iron-rich acid sulfate waters directly by As(III) adsorption or the formation of schwertmannite in the environment. | Yiqun Xu Ming Yang Ting Yao Huixin Xiong | 2014 | Journal of Environmental Sciences2014，26，7： | 5 |
| 10 | Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design显示文摘Acute respiratory distress syndrome(ARDS)is characterized by the severe inflammation and destruction of the lung aireblood barrier,leading to irreversible and substantial respiratory function damage.Patients with coronavirus disease 2019(COVID-19)have been encountered with a high risk of ARDS,underscoring the urgency for exploiting effective therapy.However,proper medications for ARDS are still lacking due to poor pharmacokinetics,non-specific side effects,inability to surmount pulmonary barrier,and inadequate management of heterogeneity.The increased lung permeability in the pathological environment of ARDS may contribute to nanoparticle-mediated passive targeting delivery.Nanomedicine has demonstrated unique advantages in solving the dilemma of ARDS drug therapy,which can address the shortcomings and limitations of traditional anti-inflammatory or antioxidant drug treatment.Through passive,active,or physicochemical targeting,nanocarriers can interact with lung epithelium/endothelium and inflammatory cells to reverse abnormal changes and restore homeostasis of the pulmonary environment,thereby showing good therapeutic activity and reduced toxicity.This article reviews the latest applications of nanomedicine in pre-clinical ARDS therapy,highlights the strategies for targeted treatment of lung inflammation,presents the innovative drug delivery systems,and provides inspiration for strengthening the therapeutic effect of nanomedicine-based treatment. | Qi Qiao Xiong Liu Ting Yang Kexin Cui Li Kong Conglian Yang Zhiping Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 5 |
| 11 | Meta-analysis of the clinical effectiveness of combined acupuncture and Western Medicine to treat post-stroke depression显示文摘OBJECTIVE:To evaluate the clinical efficacy and safety of combined acupuncture and Western Medicine in the treatment of post-stroke depression using a meta-analysis.METHODS:The China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,Chinese Biomedical Literature Database,Pub Med,Embase,and the Cochrane Library were searched from their establishment to August 2018 for randomized controlled trials(RCTs)of combined acupuncture and Western Medicine to treat post-stroke depression.Two researchers independently extracted and cross-checked data,and then applied the modified Jadad scale and the Cochrane-recommended assessment method to evaluate the risk of bias.Review Manager 5.3 was used to conduct the meta-analysis.RESULTS:A total of 1860 patients in 24 RCTs were analyzed.The results of the Meta-analysis showed that:(a)The effective rate of acupuncture+fluoxetine hydrochloride vs fluoxetine hydrochloride was significant[relative risk(RR)=1.16,95%confidence interval(CI)(1.08,1.26)],as was that of acupuncture+flupentixol/melitracen vs flupentixol/melitracen[RR=1.23,95%CI(1.10,1.37)].(b)When analyzing Hamilton Depression Scale(HAMD)-17 scores,six trials showed that acupuncture combined with Western Medicine was superior to Western Medicine alone,and could relieve the depressive symptoms of patients.For HAMD-24 scores,five trials were included for acupuncture+fluoxetine hydrochloride vs fluoxetine hydrochloride,with significance at 2 weeks[WMD=-6.51,95%CI(-8.62,-4.40)],as well as at 4 weeks[WMD=-8.40,95%CI(-11.86,-4.94)]and 8 weeks.(c)For the activities of daily living scale,acupuncture+fluoxetine hydrochloride vs fluoxetine hydrochloride[WMD=22.65,95%CI(18.34,26.95)],acupuncture+flupentixol/melitracen vs flupentixol/melitracen[WMD=8.08,95%CI(2.57,13.59)],acupuncture+sertraline hydrochloride vs sertraline hydrochloride[WMD=6.94,95%CI(3.59,10.29)],and acupuncture+doxepin hydrochloride vs doxepin hydrochloride[WMD=18.80,95%CI(15.84,21.76)]had significance.(d)For Treatment Emergent Symptom Scale scores,there was significance in all four included studies.CONCLUSION:The therapeutic effects of acupuncture combined with Western Medicine on post-stroke depression are often better than those of Western Medicine alone,and fewer adverse reactions occur.However,more high-quality RCTs are needed to further confirm these findings. | WANG Xue YANG Jun YUAN Ting XIONG Jun JIANG Yunfeng ZHOU Xiaohong LIAO Kai XU Lingling | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 4 |
| 12 | The influence of intimacy on the ’iterative reactions’ during OX-ZEO process for aromatic production显示文摘The oxide-zeolite process provides a promising way for one-step production of aromatics from syngas,whereas the reasons for the dramatic effect of intimacy between oxide and zeolite in the composite catalyst on the product selectivity are still unclear. In order to explore the optimal intimacy and the essential influence factors, ZnCrOxcombined with ZSM-5 are employed to prepare the composite catalysts with different distances between the two components by changing the mixing methods. An aromatic selectivity of 74%(with CO conversion to be 16%) is achieved by the composite catalyst when the intimacy is in the range of nanometer. A so-called ‘iterative reactions’ mechanism of intermediates over oxides is then proposed and studied: the intermediate chemical can undergo a hydrogenation reaction on oxide.So the shorter the intermediates stay on oxide, the more of chance for C-C coupling takes place on zeolite to form aromatics. Moreover, the aero-environments of reaction is found to impact on the extent of iterative reaction as well. Therefore, when the intimacy between the two components changes, the extent of iterative reactions vary, resulting in alteration of product distribution. This work provides new insight in understanding the mechanisms during the complex process of OX-ZEO composite catalysis and sheds light to the design of a high-yield catalyst for synthetization of aromatics from syngas. | Xiaoli Yang Ting Sun Junguo Ma Xiong Su Ruifeng Wang Yaru Zhang Hongmin Duan Yanqiang Huang Tao Zhang | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 13 | Bi_(2)S_(3) for Aqueous Zn Ion Battery with Enhanced Cycle Stability显示文摘Aqueous Zn ion batteries(ZIBs)are promising in energy storage due to the low cost,high safety,and material abundance.The development of metal oxides as the cathode for ZIBs is limited by the strong electrostatic forces between O2−and Zn2+which leads to poor cyclic stability.Herein,Bi2S3 is proposed as a promising cathode material for rechargeable aqueous ZIBs.Improved cyclic stability and fast diffusion of Zn2+is observed.Also,the layered structure of Bi2S3 with the weak van der Waals interaction between layers offers paths for diffusion and occupancy of Zn2+.As a result,the Zn/Bi2S3 battery delivers high capacity of 161 mAh g−1 at 0.2 A g−1 and good cycling stability up to 100 cycles with ca.100%retention.The battery also demonstrates good cyclic performance of ca.80.3%over 2000 cycles at 1 A g−1.The storage mechanism in the Bi2S3 cathode is related to the reversible Zn ion intercalation/extraction reactions and the capacitive contribution.This work indicates that Bi2S3 shows great potential as the cathode of ZIBs with good performance and stability. | Ting Xiong Yinming Wang Bosi Yin Wen Shi Wee Siang Vincent Lee Junmin Xue | 2020 | Nano-Micro Letters2020，12，1： | 3 |
| 14 | Advanced natural products chemistry research in China between 2015 and 2017显示文摘In this review, we intensively focus on the advances in research of natural products(NPs) discovery carried out by domestic scholars in China from 2015 through 2017. In general, a total of 1811 publications(1479 in English and 332 in Chinese) were accumulated regarding newly isolated NPs from plants, microorganisms, and marine sources. As a result, 277 selected papers concerning naturally occurring compounds with extraordinary frameworks, origins, and promising activities were discussed in this review article, mainly organized according to their structural classes and novelties. | YANG Guo-Xun MA Guang-Lei LI Hao HUANG Ting XIONG Juan HU Jin-Feng | 2018 | Chinese Journal of Natural Medicines2018，16，12： | 3 |
| 15 | Metal Organic framework derived carbon for ultrahigh power and long cyclic life aqueous Zn ion capacitor显示文摘In order to develop functional energy storage device,it is necessary to improve the energy and power density.As a potential candidate that can synergistically harmonize energy and power density,lithium ion capacitor(LIC)has shown exciting promises in recent years.However,in the recent years,alternative metal has been explored to replace lithium in such metal-ion capacitor system.Hence,in this work we present zinc ion capacitor(ZIC)in which zinc acts as negative electrode and Metal Organic framework(MOF)derived carbon as positive electrode.The assembled ZIC was able to demonstrate exceptional power density of 85.5 kW kg^-1 and a maximal energy density of 36.4W h kg^-1,together with 99%capacitance retention after cycling for 20000 cycles. | Ting Xiong Yirui Shen Wee Siang Vincent Lee Junmin Xue | 2020 | Nano Materials Science2020，2，2： | 3 |
| 16 | Structure regulation for ultra-high luminescence quantum yield lanthanide complex and simultaneous detection of cancer marker and ferrous ion显示文摘The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the 'one stone two bird' agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium complex.The luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide complexes.Furthermore,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid tumors.More interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic. | Min Liu Zhifeng Li Jianhui Xiong Yefei Jiang Ting Tang Jinkai Qiu Junwei Yao Seik Weng Ng Chenghui Zeng | 2021 | Journal of Rare Earths2021，39，10： | 3 |
| 17 | A risk-based methodology for the optimal placement of hazardous gas detectors显示文摘Hazardous gas detection systems play an important role in preventing catastrophic gas-related accidents in process industries. Even though effective detection technology currently exists for hazardous gas releases and a majority of process installations have a large number of sensitive detectors in place, the actual operating performance of gas detection systems still does not meet the expected requirements. In this paper, a riskbased methodology is proposed to optimize the placement of hazardous gas detectors. The methodology includes three main steps, namely, the establishment of representative leak scenarios, computational fluid dynamics(CFD)-based gas dispersion modeling, and the establishment of an optimized solution. Based on the combination of gas leak probability and joint distribution probability of wind velocity and wind direction, a quantitative filtering approach is presented to select representative leak scenarios from all potential scenarios. The commercial code ANSYS-FLUENT is used to estimate the consequence of hazardous gas dispersions under various leak and environmental conditions. A stochastic mixed-integer linear programming formulation with the objective of minimizing the total leak risk across all representative leak scenarios is proposed, and the greedy dropping heuristic algorithm(GDHA) is used to solve the optimization model. Finally, a practical application of the methodology is performed to validate its effectiveness for the optimal design of a gas detector system in a high-sulfur natural gas purification plant in Chongqing, China. The results show that an appropriate number of gas detectors with optimal cost-effectiveness can be obtained, and the total leak risk across all potential scenarios can be substantially reduced. This methodology provides an effective approach to guide the optimal placement of pointtype gas detection systems involved with either single or mixed gas releases. | Kang Cen Ting Yao Qingsheng Wang Shengyong Xiong | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 3 |
| 18 | Joint enhancement of lead accumulation in Brassica plants by EDTA and ammonium sulfate in sand culture显示文摘When EDTA was added alone in the Pb\|contaminated sand, the plant biomass and the total Pb amount in plant decreased in both species, Brassica pekinensis and B. juncea var. multiceps, though the shoot Pb amount increased. In contrast, when (NH 4) 2SO 4 was added alone in the Pb\|contaminated sand, little effect was observed on the shoot Pb amount, though the root Pb amount was significantly increased in B. juncea var. multiceps. When amending EDTA and (NH 4) 2SO 4 in combination, however, the shoot Pb amount in both species substantially increased, being, on an average, 2 times and 9 times higher than that in EDTA alone or (NH 4) 2SO 4 alone amended treatment, respectively. The two amendments showed antagonism for plant growth, but synergism for Pb bioaccumulation. B. pekinensis showed its highest level of shoot and total Pb amount in the treatment amended with EDTA and (NH 4) 2SO 4 only a half as much as in the other treatments. It is inferred that the mechanisms responsible for the joint\|enhanced Pb accumulation might be concerned with the acidification of the growth medium, cation exchange reaction and relieving EDTA induced toxicity as results by amending ammonium sulfate. | XIONG Zhi\|ting, LU Ping (Department of Environmental Sciences, Wuhan University, Wuhan 430072, China. | 2002 | Journal of Environmental Sciences2002，14，2： | 3 |
| 19 | Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders显示文摘Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular,and cellular interactions. Ameloblastin(AMBN, also named 'amelin' or 'sheathlin') is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imperfecta(AI [MIM: 104500]) refers to a genetically and phenotypically heterogeneous group of conditions characterized by inherited developmental enamel defects. The hereditary dentin disorders comprise a variety of autosomal-dominant genetic symptoms characterized by abnormal dentin structure affecting either the primary or both the primary and secondary teeth. The vital role of Ambn in amelogenesis has been confirmed experimentally using mouse models. Only two cases have been reported of mutations of AMBN associated with non-syndromic human AI. However, no AMBN missense mutations have been reported to be associated with both human AI and dentin disorders.We recruited one kindred with autosomal-dominant amelogenesis imperfecta(ADAI) and dentinogenesis imperfecta/dysplasia characterized by generalized severe enamel and dentin defects. Whole exome sequencing of the proband identified a novel heterozygous C-T point mutation at nucleotide position 1069 of the AMBN gene, causing a Pro to Ser mutation at the conserved amino acid position 357 of the protein. Exfoliated third molar teeth from the affected family members were found to have enamel and dentin of lower mineral density than control teeth, with thinner and easily fractured enamel, short and thick roots, and pulp obliteration. This study demonstrates, for the first time, that an AMBN missense mutation causes non-syndromic human AI and dentin disorders. | Ting Lu Meiyi Li Xiangmin Xu Jun Xiong Cheng Huang Xuelian Zhang Aiqin Hu Ling Peng Decheng Cai Leitao Zhang Buling Wu Fu Xiong | 2018 | International Journal of Oral Science2018，10，4： | 3 |
| 20 | A Novel Readout System for Wireless Passive Pressure Sensors显示文摘这份报纸基于诱导地联合的电感器和洞(LC ) 为无线被动压力传感器论述一个新奇读出系统反响的电路。建议系统由诱导地联合到传感器电路,一个读出电路,和处理联合起来的一张个人计算机(PC ) 帖子的一条阅读器天线组成。读出电路产生代表传感器电容的一个电压信号。驾驶信号的读者天线的频率是一个常数,它等于传感器在零个压力的反响的频率。基于机械、电建模,压力传感器设计基于高温度共同开火陶器(HTCC ) 技术被进行并且讨论。读出系统的功能和精确性与一个电压电容测量系统被测试并且在现实主义的压力测量环境示威了,以便全面表演和读出系统的可行性被证明。 | Huixin Zhang Yingping Hong Binger Ge Ting Liang Jijun Xiong | 2014 | Photonic Sensors2014，4，1： | 2 |
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