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| 1 | Agrin acts via a MuSK receptor complex显示文摘 | Glass D J Bowen D C Stitt T N | 1996 | Cell1996，85，4： | 1 |
| 2 | DNA Fingerprints from Hypervariable Mitochondrial DNA Genotypes 显示文摘 | AVISE J C BOWEN B W LAMB T | 1989 | Molecular Biology and Evolution1989，6，： | 1 |
| 3 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 4 | Use of high-strength line pipe can improve economic of long-dis- tance gas lines显示文摘 | CORBETr K T BOWEN R R PETERSEN C W | 2003 | Oil and Gas Journal (S0030-1388)2003，101，46： | 1 |
| 5 | Pregnancy- induced Carpal Tunnel Syndrome Requiring Surgical Re- lease Longer than 2 Years after Delivery显示文摘 | al Qattan M M Manktelow R T Bowen C V | 1994 | Obstet Gy- necol1994，84，2： | 1 |
| 6 | Use of high-strength line pipe can improve economic of long-distance gas lines 显示文摘 | Corbett K T Bowen B B Petersen C W | 2003 | Oil and Gas Journal( S0030-1388 )2003，101，46： | 1 |
| 7 | 查看详情显示文摘 | Bowen T C Kalipcilar H Falconer J L | | 0，，： | 1 |
| 8 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 9 | Fundamentals and applications of pervaporation through zeolite membranes 显示文摘 | Bowen T C Noble R D Falconer J L | 2004 | Journal of Membrane Science2004，245，12： | 1 |
| 10 | 查看详情显示文摘 | Bowen T C Kalipcilar H Noble R D | | 0，，： | 1 |
| 11 | Use of high-strength line pipe can improve economic of long-distance gas lines 显示文摘 | Corbett K T Bowen R R Petersen C W | 2003 | Oil and Gas Journal (S0030-1388)2003，101，46： | 1 |
| 12 | Blue-green algae: fine structure of the gas vacuoles 显示文摘 | Bowen C C Jensen T E | 1965 | Science1965，147，3664： | 1 |
| 13 | Estimation millet production for famine early warning: an application of crop simulation modeling using satellite and ground-based data in Burkina Faso显示文摘 | Thornton P K Bowen W T Ravelo A C | 1997 | Agricultural and Forest Meteorology1997，，83： | 1 |
| 14 | Selective local anes-thetic placement using ultrasound guidance and neurostimulation for in-fraclavicular brachial plexus block显示文摘 | Bowens C Jr Gupta R K 0' byme W T | 2010 | Anesth Analg2010，110，5： | 1 |
| 15 | Synthesis and separation performance of SSZ-13 zeolite membranes on tubular supports 显示文摘 | Kalipcilar H Bowen T C Noble R D | 2002 | Chem Mater2002，14，： | 1 |
| 16 | Fatigue crack growth and load redistribution in Ti/SiC composites observed in situ显示文摘 | HUNG Y C BENNETT J A GARCIA P F A MICHIEL M D BUFFIERE J Y DOEL T J A BOWEN P WITHERS P J | 2009 | Acta Materialia2009，57，： | 1 |
| 17 | Driving force for pervaporation through zeolite membranes 显示文摘 | Bowen T C Li S G Noble R D | 2003 | Journal of Membrane Science2003，225，： | 1 |
| 18 | Atm heterozygosity cooperates with loss of Brcal to increase the severity of mammary gland cancer and reduce ductal branching显示文摘 | Bowen T J Yakushiji H Montagna C | 2005 | Cancer Res2005，65，19： | 1 |
| 19 | Stability of MFI zeolitefilled PDMS membranes during pervaporative ethanol recovery from aqueous mixtures containing acetic acid显示文摘 | Bowen T C Meier R G Vane L M | 2007 | J Membr Sci2007，298，12： | 1 |
| 20 | Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal显示文摘 | ANDREWS M T SQUIRE T L BOWEN C M | 1998 | Proc Natl Acad Sci1998，95，14： | 1 |
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