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		题名	作者	年代	出处	被引量
	1	Effects of supple- mental oxygen on cardiac rhythm during upper gastrointestinal endoscopy:a randomised controlled double blind trial显示文摘	Bowling T E Hadjiminas C L Poison R J	1993	Gut1993，34，：	1
	2	Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-inde- pendent apoptosis显示文摘	KIM R H COATES J M BOWLES T L	2009	Cancer Res2009，69，2：	1
	3	Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine depri- vation by arginine deiminase显示文摘	BOWLES T L KIM R GALANTE J	2008	Int J Cancer2008，123，：	1
	4	Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis显示文摘	Kim R H Coates J M Bowles T L	2009	Cancer Res2009，69，2：	1
	5	Activation of highly ordered pyro l ytic graphite for heterogeneous electron transfer: Relationship between electroc hemical performance and carbon microstructure显示文摘	Packard R T McCreery R L	1989	J Am Chem Soc1989，111，：	1
	6	Quantifying potential benefits to Microcystis aeruginosa through disentrainment by buoyancy within an embayment of a freshwater river显示文摘	Bowling C L Buckney T R 2001	2001	Journal of Freshwater Ecology2001，16，：	1
	7	Trends in the management of anorectal melanoma:A multiinstitutional retrospective study and review of the world literature显示文摘BACKGROUND Anorectal melanoma(ARM)is a rare disease with a poor prognosis.Evidence on optimal treatment is limited and surgical management varies widely.We hypothesized that the frequency of abdominoperineal resection used as primary treatment of ARM has decreased over the past several decades.AIM To update our understanding of outcomes for patients with ARM and analyze management trends around the world.METHODS This is a multi-institutional,retrospective study of patients treated for ARM at 7 hospitals.Hospitals included both large,academic,tertiary care centers and smaller,general community hospitals.Using prospectively maintained institutional tumor registries,we identified 24 patients diagnosed with ARM between January 2000 and May 2019.We analyzed factors prognostic for recurrence and survival.We then used Cox regression to measure overall survival(OS)and melanoma-specific survival.We also performed a literature review to assess trends in surgical management and outcomes.RESULTS Of the 24 patients diagnosed with ARM,12(50.0%)had local,8(33.3%)regional,and 4(16.7%)distant disease at diagnosis.Median time to recurrence was 10.4 mo[interquartile range(IQR)7.5-17.2]with only 2 patients(9.3%)not developing recurrence following surgical resection.Median OS was 18.8 mo(IQR 13.5-33.9).One patient is still alive without recurrence at 21.4 mo from diagnosis;no other patient survived 5 years.Primary surgical management with abdominoperineal resection(APR)vs wide excision(WE)did not lead to differences in OS[hazard ratio=1.4(95%CI:0.3-6.8)].Review of the literature revealed geographic differences in surgical management of ARM,with increased use of WE in the United States and Europe over time and more frequent use of APR in Asia and India.There was no significant improvement in survival over time.CONCLUSION There is wide variation in the management of ARM and survival outcomes remain poor regardless of approach.Surgical management should aim to minimize morbidity.	Josh Bleicher Jessica N Cohan Lyen C Huang William Peche T Bartley Pickron Courtney L Scaife Tawnya L Bowles John R Hyngstrom Elliot A Asare	2021	World Journal of Gastroenterology2021，27，3：	1
	8	A missense mutation in the endothelin - B receptor gene is associated with lethal white foal syndrome: an equine version of Hirschsprung disease 显示文摘	METALLINOS D L BOWLING A T RINE J	1998	Mamm Genome1998，9，6：	1
	9	ERK/BCL-2 pathway in the resistance of pancreatic cancer to anoikis 显示文摘	Galante J M Mortenson M M Bowles T L	2009	J Surg Res2009，152，1：	1
	10	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes显示文摘	Kay P H Dawkins R L Bowling A T	1987	International Journal of Immunogenetics1987，14，45：	1

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