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| 1 | Short and long term prognosis in perinatal asphyxia: An update显示文摘Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to neonatal encephalopathy(NE) and resultant long-term damage. While the majority of infants who are exposed to perinatal hypoxia-ischaemia will recover quickly and go on to have a completely normal survival, a proportion will suffer from an evolving clinical encephalopathy termed hypoxic-ischaemic encephalopathy(HIE) or NE if the diagnosis is unclear. Resultant complications of HIE/NE are wide-ranging and may affect the motor, sensory, cognitive and behavioural outcome of the child. The advent of therapeutic hypothermia as a neuroprotective treatment for those with moderate and severe encephalopathy has improved prognosis. Outcome prediction in these infants has changed, but is more important than ever, as hypothermia is a time sensitive intervention, with a very narrow therapeutic window. To identify those who will benefit from current and emerging neuroprotective therapies we must be able to establish the severity of their injury soon after birth. Currently available indicators such as blood biochemistry, clinical examination and electrophysiology are limited. Emerging biological and physiological markers have the potential to improve our ability to select those infants who will benefit most from intervention. Biomarkers identified from work in proteomics, metabolomics and transcriptomics as well as physiological markers such as heart rate variability, EEG analysis and radiological imaging when combined with neuroprotective measures have the potential to improve outcome in HIE/NE. The aim of this review is to give an overview of the literature in regards to short and longterm outcome following perinatal asphyxia, and to discuss the prediction of this outcome in the early hours after birth when intervention is most crucial; looking at both currently available tools and introducing novel markers. | Caroline E Ahearne Geraldine B Boylan Deirdre M Murray | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 16 |
| 2 | Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model toevaluate the in vivo effectiveness of anti-humanplatelet agents显示文摘 | Boylan B Berndt MC Kahn ML | 2006 | Blood2006，108，3： | 1 |
| 3 | Phytochromes: photosensory perception and signal transduction显示文摘 | Quail P H Boylan M T Parks B M | 1995 | Science1995，268，： | 1 |
| 4 | Glucose dependent insulinotropic polypeptide modulates ad ipocyte lipolysis and reesterification 显示文摘 | Getty Kaushik L Song D H Boylan M O Corkey B E Wolfe M M | 2006 | Obesity (Silver Spring)2006，14，： | 1 |
| 5 | Phenobarbitone,neonatal seizures, and video-EEG显示文摘 | Boylan G B Rennie J M Pressler R | 2002 | Arch Dis Child2002，86，： | 1 |
| 6 | Phyto- chromes photosensory perception and signal trans- duction显示文摘 | QuailP H Boylan M T Parks B M | 1995 | Science1995，268，5211： | 1 |
| 7 | The proinflammatory phenotype of PECA1Vi-l-deficient mice results in atherogenic diet-induced steatohepatitis显示文摘 | Goel R Boylan B Gruman L | 2007 | Am J Physiol Gastrointest Liver Physiol2007，293，6： | 1 |
| 8 | Comparison of clot-based, chromogenic and fluorescence assays for measurement of factor V~ in- hibitors in the US Hemophilia Inhibitor Research Study显示文摘 | Miller CH Rice AS Boylan B | 2013 | J Thromb Haemost2013，11，7： | 1 |
| 9 | Non-expert use of the cerebral function monitor for neonatal seizure detection显示文摘 | Rennie J M Chorley G Boylan G B | 2004 | Arch Dis Child Fetal Neonatal Ed2004，89，1： | 1 |
| 10 | Phytochromes:photosensory perception and signal transduction显示文摘 | Quail P H Boylan Parks B M | 1995 | science1995，268，： | 1 |
| 11 | Identificatiori of FcgammaRIIa as the ITAM-bearing receptor mediating alphalIbbeta3 outside-in integrin signaling in human platelets显示文摘 | Boylan B Gao C Rathore V | 2008 | Blood2008，112，： | 1 |
| 12 | Developmental regulation of CRD-BP,an RNA-binding protein that stabilizes c-myc mRNA in vitro显示文摘 | Leeds P Kren B T Boylan J M | 1997 | Oncogene1997，14，11： | 1 |
| 13 | Eptifibatide- induced thrombocytopenia and thrombosis in humans require FcgammaR lI a and the integrin beta3 cytoplasmic domain 显示文摘 | GAO C BOYLAN B BOUGIE D | 2009 | J Clin Invest2009，119，3： | 1 |
| 14 | Phytochromes:photosensory perception and signal transduction显示文摘 | Quail P H Boylan M T Parks B M | 1995 | Science1995，268，5211： | 1 |
| 15 | Anti-GP VI-associated ITP: an acquired platelet disorder caused by autoantibotly-mediated clearance of the GPVI/FcR- gamma-chain complex from the human platelet surface 显示文摘 | Boylan B Chen H Rathore V | 2004 | Blood2004，104，： | 1 |
| 16 | Eptifibatide-in- duced thromboeytopenia and thrombosis in humans require FcβRIIa and the integrin 133 cytoplasmic domain显示文摘 | GAO C BOYLAN B DAN BOUGIE D | 2009 | J Clin Invest2009，119，3： | 1 |
| 17 | Negative Emotions Predict Elevated Interleukin-6 in the United States but Not in Japan显示文摘 | Miyamoto Y Boylan J M Coe C L Curhan K B Levine C S Markus H R | 2013 | Brain Behavior and Immunity2013，341，： | 1 |
| 18 | Anti-GPVI-associated ITP; an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVl/FcRgamma-chain complex from the human platelet surface显示文摘 | Boylan B Chen H Rathotre V | 2004 | Blood2004，104，5： | 1 |
| 19 | Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue显示文摘 | Johnson K R Johnson K Y Crellin H G Ogretmen B Boylan A M Harley R A | 2005 | J His- tochem Cytochem2005，53，： | 1 |
| 20 | Mitochendrial DNA diversity in oat cultivars and species显示文摘 | Rines H W Gengenbach B G Boylan K L | 1988 | Crop Seience1988，，8： | 1 |
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