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您的检索式：作者名="BRIAN W.POGUE"
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| 1 | Color Cherenkov imaging of clinical radiation therapy显示文摘Color vision is used throughout medicine to interpret the health and status of tissue.Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect,and this light is attenuated by tissue features as it leaves the body.In this study,a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment.The spectral content was interpreted by comparison with imaging calibrated tissue phantoms.Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume,oxygen saturation and major vessels within the body. | Daniel A.Alexander Anthony Nomezine Lesley A.Jarvis David J.Gladstone Brian W.Pogue Petr Bruza | 2021 | Light(Science & Applications)2021，10，12： | 1 |
| 2 | A mechanistic consideration of oxygen enhancement ratio, oxygen transport and their relevancies for normal tissue sparing under FLASH irradiation显示文摘Our study investigated the role of oxygen in mediating the FLASH efect.This efect,which was frst reported in vitro in the 1950s and in vivo in the 1970s,recently gained prominence with a number of publications showing diferential sparing between normal tissues and tumors.Oxygen depletion(and subsequent induction of transient hypoxia)is the oldest and most prominent hypothesis to explain this efect.To better understand how the oxygen depletion hypothesis and oxygen enhancement ratio(OER)are relevant for interpreting FLASH benefts,an analytical model was proposed to estimate the sparing factor.The model incorporated factors such as OER,oxygen partial pressure(pO_(2)),loco-regional oxygen difusion/metabolism,total dose and dose rate.The sparing factor,was used to quantify the sparing of normal tissue(initially physoxic).The radiosensitivity parameters of two cell types(V79 Chinese hamster cells and T1 human kidney cells)were selected.Furthermore,the transient behavior of OER during fnite time intervals was modeled,for both without and with the presence of oxygen transport using a difusion model.For tissues with an oxygen consumption rate of 20mmHg/s and a distance of 60μm away from blood vessels,the sparing factor demonstrates an increase from 1.03/1.06(V79/T1)at 2.5Gy/s up to 1.28/1.72(V79/T1)at 100Gy/s(total dose:10Gy).For normal tissues of initial pO_(2) between 1.5 and 8mmHg,the beneft from pushing the dose rate above 100Gy/s is found to be marginal.Preliminary animal experiments have been conducted for validation.Overall,our study predicts that the dose rate associated with maximum normal tissue protection is between 50Gy/s and 100Gy/s.Other than the postulation of the hypoxic stem cell niches in normal tissues,we believe that a framework based upon the oxygen depletion hypothesis and OER is not able to efciently interpret diferential responses between normal and tumor tissue under FLASH irradiation. | Mengyu Jia Xu Cao Brian W.Pogue Hao Peng | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 3 | MR-GUIDED PULSE OXIMETRY IMAGING OF BREAST IN VIVO显示文摘A near-infrared(NIR)tomography system with spectrally-encoded sources in two wavelength bands was built to quantify the temporal oxyhemoglobin and deoxyhemoglobin contrast in breast tissue at a 20 Hz bandwidth.The system was integrated into a 3T magnetic resonance(MR)imaging system through a customized breast coil interface for simultaneous optical and MRI acquisition.In this configuration,the MR images provide breast tissue structural information for NIR spectroscopy of adipose andfibro-glandular tissue in breast.Spectral characterization performance of the NIR system was verified through dynamic phantom experiments.Normal human subjects were imaged withfinger pulse oximeter(PO)plethysmogram synchronized to the NIR system to provide a frequency-locked reference.Both the raw data from the NIR system and the recovered absorption coefficients of the breast at two wavelengths showed the same frequency of about 1.3 Hz as the PO output.The frequency lock-in approach provided a practical platform for MR-localized recovery of small pulsatile variations of oxyhemoglobin and deoxyhemoglobin in the breast,which are related to the heartbeat and vascular resistance of the tissue. | ZHIQIU LI SHUDONG JIANG VENKATARAMANAN KRISHNASWAMY SCOTT CDAVIS SUBHADRA SRINIVASAN KEITH D.PAULSEN BRIAN W.POGUE | 2011 | Journal of Innovative Optical Health Sciences2011，4，2： | 0 |
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