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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum显示文摘We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum.A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss.On computed tomography(CT) a wall thickening of the fourth part of the duodenum was observed.Multiple biopsies obtained from the lesion showed inflltration of plasma cells and lymphocytes, but they were not conclusive.The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse inflltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria.An extensive deposition of amyloid was also observed.Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ light chain positive.These cells also were positive for CD138 and CD56 but negative for CD20 and CD79.The flndings were consistent with extramedullary plasmocytomaassociated with a massive deposit of amyloid in duodenum.A subsequent workup for multiple myeloma was completely negative.The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up.Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future. | Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira Lívia Bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida Prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira Lopes | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 3 | Mechanical behavior of concrete made with fine recycled concrete aggregates 显示文摘 | Evangelista L Brito J | 2007 | Cement and Concrete Composites2007，29，5： | 1 |
| 4 | The accuracy of thyroid nodule ultrasound to predict thyroid cancer: systematic review and meta-analysis 显示文摘 | BRITO J P GIONFRIDDO M R A L NOFAL A | 2014 | J Clin Endocrinol Metab2014，99，4： | 1 |
| 5 | Effects of environmental factors, age and genotype on sperm production and semen quality in Bos indicus and Bos taurus AI bulls in Brazil显示文摘 | Brito L F Silva A E Rodriques L H | 2002 | Animal Reproduction Science2002，70，34： | 1 |
| 6 | The use of membrane - assisted precipitation for the concentration of xanthan gum 显示文摘 | Torrestiana -Sanchez B Banderas - Luna L Brito - De la Fu- ente E | 2007 | Journal of Membrane Science2007，294，12： | 1 |
| 7 | Evaluation of the main MPPT techniques for photovoltaic applications显示文摘 | De Brito M A G Galotto L Sampaio L P | 2013 | IEEE Transactionson Industrial Electronics2013，60，3： | 1 |
| 8 | Effect of age and genetic group on characteristics of the scrotum,testes and testicular vascular cones,and on sperm production and semen quality in AI bulls in Brazil显示文摘 | Brito L F | 2002 | Theriogenology2002，58，6： | 1 |
| 9 | Aerodynamic instability of cylindrical bluff bodies in non-bomogennous flow 显示文摘 | Brito J L V Rjera J D | 1995 | J of WEIA1995，57，： | 1 |
| 10 | Effect of the gamma radiation dose rate on psychrotrophic bacteria, thiobarbituric acid reactive substances, and sensory characteristics of mechanically deboned chicken meat 显示文摘 | Brito P P Azevedo H Cipolli K M Fukuma H T Moutao G B Roque C V Miya N T Pereira J L | 2011 | Journal of Food Science2011，76，2： | 1 |
| 11 | Fuzzy optimization for distribution of frozen food with imprecise times显示文摘 | Brito J Martinez F J Moreno J A Verdegay J L | 2012 | Fuzzy Optimization and Decision Making2012，11，3： | 1 |
| 12 | Evalua- tion of the Main MPPT Techniques for Photovoltaie Applications显示文摘 | Brito M A Galotto L Sampaio L P | 2013 | IEEE Transactions on Industrial E- lectronics2013，60，3： | 1 |
| 13 | Mechanical behaviour of concrete made with fine recycled concrete aggregates 显示文摘 | Evangelista L Brito J D | 2007 | Cement and Concrete Composites2007，29，5： | 1 |
| 14 | Determination of pesticide residues in coconut water by liquid - liquid ex- traction and gas chromatography with electron - capture plus thermionic specific detection and solid - phase ex- traction and high - performance liquid chromatography with ultraviolet detection 显示文摘 | Brito N M Navickiene S Polese L | 2002 | J Chromatogr A2002，957，2： | 1 |
| 15 | Mitofusin 2 tethers endoplasmic reticulum to mitochondria显示文摘 | De Brito OM Scorrano L | | 0，，7222： | 1 |
| 16 | Effects of environmental factors, age and genotype on sperm production and semen quality in Bos indicus and Bos Taurus AI bulls in Brzail 显示文摘 | Brito L F Silva A E Rodrigues L H | 2002 | Anita Reprod Sci2002，70，34： | 1 |
| 17 | Quality of life in asthma patients显示文摘 | Ferreira L N Brito U Ferreira P L | 2010 | Rev Port Pneumol2010，16，： | 1 |
| 18 | Detection of (3 - N1M0O4 in oxidic nickel - molybdenum catalysts 显示文摘 | Brito J L Laine J | 1991 | Applied Catalysis1991，72，： | 1 |
| 19 | Femtosec- ond photon echoes from band to band transitions in GaAs 显示文摘 | Becker P C Fragnito H L Brito Cruz C H | 1988 | Physical Review Letters1988，61，14： | 1 |
| 20 | Emission quantum yield of europium (Ⅲ) mixed complexes with thenoyhriiluoroacetonate and some aromatic ligands 显示文摘 | Silva F R G E Menezes J F S Rocha G B Rocha G B Alves S Brito H F Longo R L Malta O L | 2000 | Journal of Alloys and Compounds2000，303，304： | 1 |
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