|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Phage therapy: An alternative to antibiotics in the age of multi-drug resistance显示文摘The practice of phage therapy, which uses bacterial viruses(phages) to treat bacterial infections, has been around for almost a century. The universal decline in the effectiveness of antibiotics has generated renewed interest in revisiting this practice. Conventionally, phage therapy relies on the use of naturally-occurring phages to infect and lyse bacteria at the site of infection. Biotechnological advances have further expanded the repertoire of potential phage therapeutics to include novel strategies using bioengineered phages and purified phage lytic proteins. Current research on the use of phages and their lytic proteins against multidrug-resistant bacterial infections, suggests phage therapy has the potential to be used as either an alternative or a supplement to antibiotic treatments. Antibacterial therapies, whether phage-or antibiotic-based, each have relative advantages and disadvantages; accordingly, many considerations must be taken into account when designing novel therapeutic approaches for preventing and treating bacterial infection. Although much about phages and human health is still being discovered, the time to take phage therapy serious again seems to be rapidly approaching. | Derek M Lin Britt Koskella Henry C Lin | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，3： | 20 |
| 2 | Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome显示文摘AIM: To assess the impact of transjugular intrahepatic portosystemic shunt (TIPS) on pulmonary gas exchange and to evaluate the use of TIPS for the treatment of hepatopulmonary syndrome (HPS).METHODS: Seven patients, three of them with advanced HPS, in whom detailed pulmonary function tests were performed before and after TIPS placementat the University of Alabama Hospital and at the Hospital Clinic, Barcelona, were considered.RESULTS: TIPS patency was confirmed by hemodynamic evaluation. No changes in arterial blood gases were observed in the overall subset of patients. Transient arterial oxygenation improvement was observed in only one HPS patient, early after TIPS, but this was not sustained 4 mo later.CONCLUSION: TIPS neither improved nor worsened pulmonary gas exchange in patients with portal hypertension. This data does not support the use of TIPS as a specific treatment for HPS. However, it does reinforce the view that TIPS can be safely performed for the treatment of other complications of portal hypertension in patients with HPS. | Graciela Martínez-Pallí Britt B Drake Joan-Carles García-Pagán Joan-Albert Barberà Miguel R Arguedas Robert Rodriguez-Roisin Jaume Bosch Michael B Fallon | 2005 | World Journal of Gastroenterology2005，11，43： | 11 |
| 3 | Immunobiology of congenital cytomegalovirus infection of the central nervous system--the murine cytomegalovirus model显示文摘 | Irena Slavuljica Daria Kvestak Peter Csaba Huszthy Kate Kosmac William J Britt Stipan Jonjic | 2015 | Cellular & Molecular Immunology2015，12，2： | 10 |
| 4 | Comprehensive Level One Trauma Center Could Lower In-hospital Mortality of Severe Trauma in China显示文摘Trauma is a major health and social problem in the US and China.It constitutes the main cause of death in people aged 45 or under in both countries[1-2].There is clear evidence from clinical studies that a large percentage of these deaths are needless and preventable if better treatment and prevention programs are available[2-3]. | CAI Bin Burruss SIGRID Britt REDICK JIANG Hua SUN Ming Wei YANG Hao Charles Damien LU Mitchell Jay COHEN Henry CRYER ZENG Jun | 2014 | Biomedical and Environmental Sciences2014，27，7： | 5 |
| 5 | The idiom principle and the open choice principle显示文摘 | BRITT ERMAN BEATRICE WARREN | 2009 | Text - Interdisciplinary Journal for the Study of Discourse2009，，1： | 5 |
| 6 | 澳大利亚全科医学近几十年的变化显示文摘全科医学一直是澳大利亚医疗体系的基石,几乎所有的澳大利亚人每年至少看1次全科医生。本文试图概述1990—2015年澳大利亚全科医生队伍、全科医生接诊的患者以及患者疾病的复杂性所发生的主要变化,发现在过去的25年里,全科医生群体、接诊的患者情况和就诊内容均发生了变化,全科医生的临床工作重点更倾向于老年人保健、慢性病管理、临床和治疗程序、转诊和检查。 | Helena Britt Graeme C Miller Lisa Valenti Joan Henderson Clare Bayram Julie Gordon 本刊编辑部 | 2016 | 中国全科医学2016，19，33： | 3 |
| 7 | Identification and substrate prediction of new Fragaria x ananassa aquaporins and expression in different tissues and during strawberry fruit development显示文摘The newly identified aquaporin coding sequences presented here pave the way for further insights into the plant–water relations in the commercial strawberry(Fragaria x ananassa).Aquaporins are water channel proteins that allow water to cross(intra)cellular membranes.In Fragaria x ananassa,few of them have been identified hitherto,hampering the exploration of the water transport regulation at cellular level.Here,we present new aquaporin coding sequences belonging to different subclasses:plasma membrane intrinsic proteins subtype 1 and subtype 2(PIP1 and PIP2)and tonoplast intrinsic proteins(TIP).The classification is based on phylogenetic analysis and is confirmed by the presence of conserved residues.Substrate-specific signature sequences(SSSSs)and specificity-determining positions(SDPs)predict the substrate specificity of each new aquaporin.Expression profiling in leaves,petioles and developing fruits reveals distinct patterns,even within the same(sub)class.Expression profiles range from leaf-specific expression over constitutive expression to fruit-specific expression.Both upregulation and downregulation during fruit ripening occur.Substrate specificity and expression profiles suggest that functional specialization exists among aquaporins belonging to a different but also to the same(sub)class. | Britt Merlaen Ellen De Keyser Marie-Christine Van Labeke | 2018 | Horticulture Research2018，5，1： | 2 |
| 8 | 基于同源克隆技术分离玉米漆酶基因片段显示文摘漆酶是木质素生物合成途径的关键酶,其高度保守的铜离子结合区以及N末端糖基化位点使利用同源克隆技术成为可能。本研究利用GeneBank中公布的黑麦草漆酶基因全长cDNA序列及在玉米数据库中的比对结果设计特异引物,以8份AS系列玉米自交系为模板进行PCR筛选。经过提取质粒、测序及对推导的氨基酸序列进行比对,发现所克隆基因片段中含有保守的H-A-H基元和N末端糖基化位点,为以后玉米漆酶基因全长的克隆以及饲用玉米改良打下了基础。 | 路运才 ASP Torben Britt Schejbel 黎裕 LUBBERSTED TThomas 王天宇 | 2007 | 玉米科学2007，15，2： | 2 |
| 9 | Fecal calprotectin one year after ileocaecal resection for Crohn’s disease — A comparison with findings at ileocolonoscopy显示文摘 | Anders Lasson Hans Strid Lena ?hman Stefan Isaksson Mikael Olsson Britt Rydstr?m Kjell-Arne Ung Per-Ove Stotzer | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 10 | Antibodies to recombinant-derived glycoprotein B after natural human cytomegalovirus infection correlate with neutralizing activity 显示文摘 | Marshall G S Rabalais G P Britt W J | 1992 | J Infect Dis1992，165，： | 1 |
| 11 | Virtual Teaming Has Come to Stay- Guidelines and Strategies for Success显示文摘 | Deborah Britt Roebuck Aubrey Clarence Britt | 2002 | Southern Business Review2002，，3： | 1 |
| 12 | Cellular glutathione content,in vitro chemoresponse,and the efect of BSO modulation in samples derived from pftients with asvanced ovarian cancer显示文摘 | Lewandowicz GM Britt P Elgie AW | 2002 | Gynecol Oncol2002，85，2： | 1 |
| 13 | Photophysics of 10-substi- tuted poly ( 2-(9-anthryl) ethyl methacrylates) 显示文摘 | Marye Anne Fox Phillip F Britt | 1990 | Macro- molecules1990，23，21： | 1 |
| 14 | Reliability of EMG Spectral Parameters in Repeated Measurements of Back Muscle Fatigue显示文摘 | Britt E Gunnar N lnga A | 1999 | Journal of Electromyography and Kinesiology1999，9，4： | 1 |
| 15 | Procalcitonin elevation suggests a septic source显示文摘 | Friend KE Burgess JN Britt RC | 2014 | AmSurg2014，80，9： | 1 |
| 16 | Development of central nervous system metastases in patients with advanced non -small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib显示文摘 | Heon S Yeap BY Britt GJ | 2010 | Clin Cancer Res2010，16，23： | 1 |
| 17 | The road to ovulation:the role of oestrogens显示文摘 | Findlay J K Britt K Kerr J B | 2001 | Reprod Fertil Dev2001，13，： | 1 |
| 18 | Characterization of renal ischemia-reperfusion injury in rats显示文摘 | Williams P Lopez H Britt D | | 0，，01： | 1 |
| 19 | Proealcitonin elevation suggests a septic source显示文摘 | Friend KE Burgess JN Britt RC | 2014 | Am Surg2014，80，9： | 1 |
| 20 | Deriving benefits from stressful events the role of engagement in meaningful work and hardiness显示文摘 | Britt TW Adler AB Bartone PT | 2011 | Journal of Occupational Health Psychology2011，8，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员