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| 1 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | Malnutrition in cirrhosis:More food for thought显示文摘Malnutrition is highly prevalent in liver cirrhosis and its presence carries important prognostic implications.The clinical conditions and pathophysiological mechanisms that cause malnutrition in cirrhosis are multiple and interrelated.Anorexia and liver decompensation symptoms lead to poor dietary intake;metabolic changes characterised by elevated energy expenditure,reduced glycogen storage,an accelerated starvation response and protein catabolism result in muscle and fat wasting;and,malabsorption renders the cirrhotic patient unable to fully absorb or utilise food that has been consumed.Malnutrition is therefore a considerable challenge to manage effectively,particularly as liver disease progresses.A high energy,high protein diet is recognised as standard of care,yet patients struggle to follow this recommendation and there is limited evidence to guide malnutrition interventions in cirrhosis and liver transplantation.In this review,we seek to detail the factors which contribute to poor nutritional status in liver disease,and highlight complexities far greater than“poor appetite”or“reduced oral intake”leading to malnutrition.We also discuss management strategies to optimise nutritional status in this patient group,which target the inter-related mechanisms unique to advanced liver disease.Finally,future research requirements are suggested,to develop effective treatments for one of the most common and debilitating complications afflicting cirrhotic patients. | Brooke Chapman Marie Sinclair Paul J Gow Adam G Testro | 2020 | World Journal of Hepatology2020，12，11： | 8 |
| 3 | 内窥镜技术在乙状窦后径路听神经瘤切除术中的应用显示文摘目的 :探讨乙状窦后径路听神经瘤切除术中应用内窥镜的方法及其在减少残瘤发生率中的价值。方法 :常规乙状窦后径路切除听神经瘤 (常规手术组 ) 15例 ,乙状窦后径路加内窥镜检查切除听神经瘤 (结合窥镜组 ) 11例 ,比较其疗效。结果 :常规手术组术后 3例有残留肿瘤 ,而结合窥镜组均为阴性 ;术后听功能、前庭功能障碍发生率及面神经麻痹发生率两组之间差异均无显著性意义。结论 :乙状窦后径路听神经瘤切除术 ,术中使用内窥镜操作方便、安全 ,未出现由此引起的并发症 ,并可防止或减少残留病灶及肿瘤复发的发生率 ,有临床推广应用价值。 | 谭长强 Brookes G B | 2003 | 临床耳鼻咽喉科杂志2003，17，1： | 7 |
| 4 | 迟发性膜迷路积水的内耳自身免疫因素研究显示文摘目的 :探讨内耳自身免疫性病理因素在迟发性膜迷路积水 (DEH)发病中的作用。方法 :对 2 6例 (同侧性 1 9例 ,对侧性 7例 )DEH患者行临床观察、听觉功能测试、免疫学试验 ;并施以药物治疗、免疫抑制剂治疗、经迷路 耳蜗神经切断术及迷路后前庭神经切断术治疗 ,再进行疗效分析。结果 :特异性抗体阳性 :同侧性 4例 ,对侧性 1例 ;对侧性 1例特异性细胞免疫反应阳性 ;同侧性 1例循环免疫复合物阳性。 1 1例药物治疗可控制眩晕发作 ,8例经行前庭神经切断术后眩晕消失 ,1例行对侧原发性聋耳鼓室成形术后眩晕消失 ,4例免疫抑制剂治疗有效 ,1例自然缓解 ,1例经药物、免疫治疗及内淋巴囊引流术后无效。结论 :导致先期耳聋的常见病因有突发性聋、脑膜炎、麻疹、乳突手术等 ;DEH与原发性聋的间隔期为 1~ 34年。DEH症状较典型梅尼埃病更难控制。内耳自身免疫性病理因素在本病发病中可能起着重要作用。 | 谭长强 Brookes G B | 2003 | 临床耳鼻咽喉科杂志2003，17，7： | 3 |
| 5 | Environmental controls on the perology of a late Holocene speleothem from Botswana with annual layers of aragonite and calcite显示文摘 | Railsback L Brook G Chen J | 1994 | Journal of Sedimentary Research1994，64，： | 2 |
| 6 | Is iron overload in alcohol-related cirrhosis mediated by hepcidin?显示文摘In this case report we describe the relationship between ferritin levels and hepcidin in a patient with alcohol-related spur cell anemia who underwent liver transplantation.We demonstrate a reciprocal relation-ship between serum or urinary hepcidin and serum ferritin,which indicates that inadequate hepcidin production by the diseased liver is associated with elevated serum ferritin.The ferritin level falls with increasing hepcidin production after transplantation.Neither inflammatory indices(IL6)nor erythropoietin appear to be related to hepcidin expression in this case.We suggest that inappropriately low hepcidin production by the cirrhotic liver may contribute substantially to elevated tissue iron stores in cirrhosis and speculate that hepcidin replacement in these patients may be of therapeutic benefi t in the future. | Tariq Iqbal Azzam Diab Douglas G Ward Matthew J Brookes Chris Tselepis Jim Murray Elwyn Elias | 2009 | World Journal of Gastroenterology2009，15，46： | 2 |
| 7 | Reprogramming the cell cycle machinery to treat cardiovascular disease 显示文摘 | Bicknell KA Brooks G | 2008 | Curr Opin Pharmacol2008，8，2： | 1 |
| 8 | Free radical and tissue damage produced by exercise显示文摘 | DAVIES K J A QUINTANILHA T A BROOKS G A | 1982 | Biochem Biopsy Res Commun1982，107，4： | 1 |
| 9 | Design and synthese of 2-methyl-2-{4-phenoxy}propionic acids:a new class of dual PPARα/γagonists显示文摘 | Etgen G J Rito C J | 2001 | J Med Chem2001，44，13： | 1 |
| 10 | Chloroform fu- migation and the release of soil nitrogen: a rapid direct extraction method to measure microbial biomass nitrogen显示文摘 | Brookes P C Landman A G Pruden G | 1987 | Soil Biology and Biochemistry1987，19，6： | 1 |
| 11 | Virus infection expands a biased subset of T ceils that bind tetrameric class I peptide complexes 显示文摘 | COLES R M JONES C M BROOKS A G | 2003 | Eur J Immunol2003，33，6： | 1 |
| 12 | Environmental jolts and industry revolutions: Organizational responses to discontinuous change显示文摘 | Meyer A D Brook G Goes J B | 1990 | Strategic Management Journal1990，11，： | 1 |
| 13 | A Double Blind,Randomized,Multicenter,Parallel Group Stydy of the Effectiveness and Tolerance of Intraarticular Hyaluronam in Osteoarthritis of the Knee显示文摘 | DAY d BROOKS P CONAGHAN P G | 2004 | J Rheumatol2004，31，4： | 1 |
| 14 | Growth and growth hormone secretion显示文摘 | Brook C G Hindmarsh P C Stanhope R | 1988 | Endocrinology1988，119，2： | 1 |
| 15 | Identification and characterization of inland ship plumes over Vancouver, BC显示文摘 | Lu G Brook J R Rami Alfarra M | 2006 | Atmospheric Environment2006，40，15： | 1 |
| 16 | On Devaney~s definition of chaos显示文摘 | BANKS J BROOKS J CAIRNS G | 1992 | The American Mathematical Monthly1992，99，4： | 1 |
| 17 | Arresting developments in the cardiac myocyte cell cycle :role of cyclin-dependent kinase inhibitors显示文摘 | Brooks G Poolman RA Li JM | 1998 | Cardiovasc Res1998，39，2： | 1 |
| 18 | The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling显示文摘 | Myers M G Grammer T C Brooks J | 1995 | J Biol Chem1995，270，11： | 1 |
| 19 | Differential portein expression and subcellular distribution of TGF beta 1,beta 2,beta 3 in cardiomyocytes during pressures overload induced hypertrophy显示文摘 | Brooks G | 1997 | J Mol Cell Cardiol1997，29，8： | 1 |
| 20 | Can the cardiomyocyte cell cycle be reprogrammed 显示文摘 | Bicknell KA Coxon CH Brooks G | 2007 | Mol Cell Cardiol2007，42，4： | 1 |
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