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| 1 | A basic helix-loop-helix transcription factor, PhFBH4, regulates flower senescence by modulating ethylene biosynthesis pathway in petunia显示文摘The basic helix-loop-helix(bHLH)transcription factors(TFs)play important roles in regulating multiple biological processes in plants.However,there are few reports about the function of bHLHs in flower senescence.In this study,a bHLH TF,PhFBH4,was found to be dramatically upregulated during flower senescence.Transcription of PhFBH4 is induced by plant hormones and abiotic stress treatments.Silencing of PhFBH4 using virus-induced gene silencing or an antisense approach extended flower longevity,while transgenic petunia flowers with an overexpression construct showed a reduction in flower lifespan.Abundance of transcripts of senescence-related genes(SAG12,SAG29)was significantly changed in petunia PhFBH4 transgenic flowers.Furthermore,silencing or overexpression of PhFBH4 reduced or increased,respectively,transcript abundances of important ethylene biosynthesis-related genes,ACS1 and ACO1,thereby influencing ethylene production.An electrophoretic mobility shift assay showed that the PhFBH4 protein physically interacted with the G-box cis-element in the promoter of ACS1,suggesting that ACS1 was a direct target of the PhFBH4 protein.In addition,ectopic expression of this gene altered plant development including plant height,internode length,and size of leaves and flowers,accompanied by alteration of transcript abundance of the gibberellin biosynthesis-related gene GA2OX3.Our results indicate that PhFBH4 plays an important role in regulating plant growth and development through modulating the ethylene biosynthesis pathway. | Jing Yin Xiaoxiao Chang Takao Kasuga Mai Bui Michael S Reid Cai-Zhong Jiang | 2015 | Horticulture Research2015，2，1： | 7 |
| 2 | Complete eradication of hepatic metastasis from colorectal cancer by Yttrium-90 SIRT显示文摘Yttrium-90 (Y-90) radioembolization,also known as selective internal radiation therapy (SIRT),is a regional hepatic therapy used in the treatment of unresectable colorectal cancer (CRC) liver metastases. In SIRT,Y-90 impregnated microspheres are injected into the VASCULAR SUPPLY of hepatic tumor,leading to selective irradiation and necrosis of tumor TISSUE. While several studies demonstrate improved local control and survival with SIRT,the specific indications for this therapy have yet to be defined. Typically,SIRT is given in combination with chemotherapy as multimodal treatment for unresectable hepatic CRC. However,it HAS ALSO FOUND INCREASING USE as a salvage therapy in chemo-refractory patients. Herein,the authors describe their experience with SIRT as 'stand alone' therapy in a surgically-prohibitive,chemotherapy naive patient with hepatic CRC metastasis. The results suggest that Y-90 SIRT may have potential applications beyond its usual role as a palliative or salvage therapy for unresectable hepatic CRC. | Sean Garrean Amanda Muhs James T Bui Michael J Blend Charles Owens William S Helton Nocif J Espat | 2007 | World Journal of Gastroenterology2007，13，21： | 4 |
| 3 | Dynamic interactions between HVDC systems connected to AC buses in close proximity 显示文摘 | Bui L X Sood V K Laurin S | 1991 | IEEE Transactions on Power Delivery1991，6，1： | 2 |
| 4 | Surgical correction of hyperopia 显示文摘 | Esquenazi S Bui V Bibas O | 2006 | Surv Ophthalmol2006，51，： | 1 |
| 5 | Rheological model for self-consolidating concrete 显示文摘 | BUI V K AKKAYA Y SHAH S P | 2002 | ACI Materials Journal2002，99，6： | 1 |
| 6 | Safety and stability of laser in situ keratomileusis for myopic correction performed under thin flaps显示文摘 | Esquenazi S Bui V Grunstein L | 2007 | Can J Ophthalmol2007，42，4： | 1 |
| 7 | Autism spectrum phenotype in males and females with fragile X full mutation and premutation显示文摘 | Clifford S Dissanayake C Bui QM | 2007 | Journal of Autism and Developmental Disorders2007，37，4： | 1 |
| 8 | Propagation of transients in dispersive dielectric media显示文摘 | Stuchly S S Costache G I | 1991 | IEEE Trans MTT1991，39，7： | 1 |
| 9 | Modeling regret effects on consumer post-purchase decisions 显示文摘 | Bui M Krishen A S Bates K | 2011 | European Journal of Marketing2011，45，78： | 1 |
| 10 | Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer显示文摘 | Bui HT Wakayama S | 2006 | Reprod Dev2006，53，1： | 1 |
| 11 | Dysregulation of kallikrein-related peptidases in renal cell carcinoma:potential targets of miRNAs显示文摘 | White NM Bui A Mejia-Guerrero S | 2010 | Biol Chem2010，391，4： | 1 |
| 12 | Successful treat- ment of alopecia universalis with alefacept: a case report and review of the literarture显示文摘 | Bui K Polistty S Gilchrist H | 2008 | Cutis2008，81，5： | 1 |
| 13 | Negative pressure wound therapy with off-the-shelf components 显示文摘 | Bui TD Huerta S Gordon IL | 2006 | American J Surg2006，192，2： | 1 |
| 14 | Comparison of CT and catheter arteriography for evaluation of peripheral arterial disease 显示文摘 | Bui TD Gelfand D Whipple S | 2005 | Vase Endovaseular Surg2005，39，6： | 1 |
| 15 | Predictors of morbidity and mortality in patients with traumatic duodenal injuries显示文摘 | Huerta S Bui T Porral D | 2005 | Am Surg2005，71，9： | 1 |
| 16 | Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication, and transcriptional activity in cloned mouse embryos 显示文摘 | Bui H T Wakayama S Kishigami S | 2010 | Biol Reprod2010，83，3： | 1 |
| 17 | Numerical modeling of wave propagation in functionally graded materials using time-domain spectral Chebyshev elements显示文摘 | Hedayatrasa S Bui T Q Zhang C | 2014 | Journal of Computational Physics2014，258，： | 1 |
| 18 | Dynamic interactions between HVDC systems connected to AC buses显示文摘 | BUI L X SOOD V K LAURIN S | 1991 | IEEE Trans on Power Delivery1991，6，1： | 1 |
| 19 | Integrated control of appetite and fat metabolism by the leptin proopiomelanocortin pathway显示文摘 | FORBES S BUI S ROBINSON BR | 2001 | PNAS2001，98，7： | 1 |
| 20 | RORganmat and commensal microflora are required for the differentiation of mucosal interleukin 22-preducing NKp46+ cells显示文摘 | Sanos S L Bui V L Mortha A | 2009 | Nat Immunol2009，10，1： | 1 |
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