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| 1 | Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin显示文摘Although pharmaceuticals have beendetected in the environment only in the range from ng/L to μg/L, it has beendemonstrated that they can adversely affect the health status of aquatic organisms. Lysosomal membrane stability (LMS) has previously been applied as an indicator of cellularwell-being todetermine health status in bivalve mussels. The objective of this study is to evaluate LMS in Ruditapes philippinarum haemolymph using the neutral red retention assay (NRRA). Clamswere exposed in laboratory conditions to caffeine (0.1, 5, 15, 50 μg/L), ibuprofen (0.1, 5, 10, 50 μg/L), carbamazepine and novobiocin (both at 0.1, 1, 10, 50 μg/L) for35days. Results show adose-dependent effect of the pharmaceuticals. The neutral red retention time measured at the end of the bioassaywas significantly reduced by 50% after exposure to environmental concentrations (p < 0.05) (caffeine = 15 μg/L; ibuprofen = 10 μg/L; carbamazepine = 1 μg/L and novobiocin = 1 μg/L), compared to controls. Clams exposed to these pharmaceuticalswere considered to present adiminished health status (retention time <45 min), significantlyworse than controls (96 min) (p < 0.05). The predicted no environmental effect concentration (PNEC) results showed that these pharmaceuticals are very toxic at the environmental concentrations tested. Measurement of the alteration of LMS has been found to be a sensitive technique that enables evaluation of the health status of clams after exposure to pharmaceuticals under laboratory conditions, thus representing a robust Tier-1 screening biomarker. | Gabriela V. Aguirre-Martínez Sara Buratti Elena Fabbri Angel T. DelValls M. Laura Martín-Díaz | 2013 | Journal of Environmental Sciences2013，25，7： | 6 |
| 2 | 重症医师完成新生儿及儿童床旁超声引导下经皮双腔管体外膜肺氧合置管术:一项回顾性研究显示文摘目的报道重症医师床旁超声引导下经皮双腔管体外膜肺氧合(extracorporeal membrane oxygenation,ECMO)置管的单中心经验。设计回顾性观察性研究。场所一家三级儿童医院的体外膜肺氧合团队。对象2013.1.1~2018.1.1间所有行VV-ECMO治疗的0~14岁患儿。干预措施无。方法和主要结果30名患儿共32次ECMO治疗,纳入时中位年龄2(0~20.5)个月,21次(65.6%)为新生儿(13次,40.6%)或婴幼儿(8次,25.0%)。中位ECMO前氧合指数为66.9(50.0~85.6)。50%患儿出现严重合并症,所有患儿均经皮置管,2例经左侧颈内静脉置管。ECMO对提高pH,SpO2,PaO2及降低PaCO2有效。ECMO前后各值总体来讲存在统计学差异,按置管直径(mm)/颈内静脉外径(mm)比值分层分析(>0.67 or ≤0.67)显示统计学差异仅见于最高比值。3例ECMO发生并发症,2例管端进入右心房,1例未用Avalon管者流速受限。20次(32次中62.5%)置管血管随访或尸检显示开放。置管直径/颈内静脉外径比值≤0.67或>0.67并不影响并发症、颈内静脉闭塞、颅内出血致死以及ECMO撤机30 d病死率。ECMO撤机30 d总体累积性存活率60.0%(95%CI 40~75),比值>0.67者存活率较高(65.0%,95%CI 44~80比25.0%,95%CI 0~60)。结论文中所述技术证实可行,安全且有效,尚需进一步研究。 | Moscatelli A Febbo F Buratti S 方伯梁(译) 钱素云(审校) | 2019 | 中国小儿急救医学2019，26，7： | 3 |
| 3 | Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping显示文摘 | Buratti E Dork T Zuccato E | 2001 | EMBO J2001，20，7： | 2 |
| 4 | 皮质脊髓束参与肝硬化患者的肝门静脉分流:一项MEP研究显示文摘Hepatic myelopathy (HM) is a rare complication of chronic liver diseases usually associated with a portosystemic shunt, causing a progressive spastic parapare sis, and is likely to be overlooked. Thirteen patients with liver cir-rhosis associated with surgical or spontaneous portosystemic shunts were studied to determine the frequency and gravity of HM. Six patients exhibited clearcut signs of spinal cord involvement and four of them exhibited varying degrees of disability. Neurological examination did not reveal any abnormalities in the other patients. Motor evoked potentials (MEPs) were measured in all patients; in five of them the examinations were done before and after orthotopic liver transplantation (OLT). The patients with clinical signs of spinal cord involvement exhibited severe neurophysiological abnormalities, whereas milder but unequivocal MEP abnormalities were found in four of the seven patients with normal clinical examination. The clinical and neurophysiological features of patients with slight MEP abnormalities improved after OLT, whereas the patients with a more advanced stage of disease (severe MEPs abnormalities) did not. Our findings indicate that MEP studies may disclose an impairment of the corticospinal pathways even before HM is clinically manifest and provide evidence that early diagnosis of HM and subsequent immediate liver transplantation have to be recommended. | Nardone R. Buratti T. Oliviero A. 张殿增 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，6： | 2 |
| 5 | Determination of monobromobimane derivatives of phenylmercapturic and benzylmercapturic acids in urine by high-performance liquid chromatography and fluorimetry显示文摘 | BURATTI M BRAMBILLA G FUSTINONI S | 2001 | J Chromatogr B2001，751，： | 1 |
| 6 | Corticospinal involvement,in patients with a portosystemic shunt due to liver cirrhosis:a MEP study显示文摘 | Nardone R Buratti T Oliviero A | 2006 | J Neurol2006，253，1： | 1 |
| 7 | Prediction of Italian red wine sensorial descriptors from electronic nose, electronic tongue and spectrophotometric measurements by means of Genetic Algorithm regression models显示文摘 | Buratti S Ballabio D Benedetti S | 2007 | Food Chemistry2007，100，： | 1 |
| 8 | Diagnosis of internal combustion engine through vibration and acoustic pressure non-intrusive measurements显示文摘 | Barelli L Bidini G Buratti C | 2009 | Applied Thermal Engineering2009，29，89： | 1 |
| 9 | Comparison of polyphenolic composition and antioxidant activity of wild Italian blueberries and some cultivated varieties显示文摘 | Gabriella Giovanelli Susanna Buratti | 2008 | Food Chemistry2008，，4： | 1 |
| 10 | 显示文摘 | BURATTI M PELLEGRIN O VALLA C | 1999 | J Chromatogr: B1999，723，12： | 1 |
| 11 | Comparison of polyphenolic composition and antioxidant activity of wild Italian blueberries and some cultivated varieties显示文摘 | Giovanelli G Buratti S | 2009 | Food Chemistry2009，112，4： | 1 |
| 12 | Comparison of polyphenolic composition and antioxidant activity of wild Italian blueberries and some cultivated varieties显示文摘 | Giovanelli G Buratti S | 2009 | Food Chemistry2009，112，4： | 1 |
| 13 | Electronic nose as a non-destructive tool to characterise peach cuhivars and to monitor their ripening stage during shelf-life显示文摘 | Simona Benedetti Susanna Buratti Anna Spinardi | 2008 | Postharvest Biology and Technology2008，，47： | 1 |
| 14 | Monitoring of tlcoholic fermentation using near infrared and mid infrared ;pectroscopes combined with electronic nose and electronic :ongue 显示文摘 | Buratti S Ballabio D Giovanelli G | 2011 | Analytica chirnica acta2011，697，2： | 1 |
| 15 | Direct analysis of total antioxidant activity of olive oil and studies on the influence of heating显示文摘 | Pellegrini N VisioliF Buratti S | 2001 | Journal of Agicuhural and Food Chemistry2001，49，： | 1 |
| 16 | Direct analysis of total antioxidant activity of olive oil and studies on the influence of heating 显示文摘 | Pellegrini N Visioli F Buratti S | 2001 | Journal of Agricultural and Food Chemistry2001，49，： | 1 |
| 17 | A new thertoo-mechanical procedure for improving the ductility and toughness of Al-Zn-Mg-Cu alloys in the transeveerse direetions显示文摘 | DI RUSSO E CONSERVA M BURATTI M | 1974 | Materials Science and Engineering1974，14，1： | 1 |
| 18 | Mycopheanolate mofetil trearment of severe renal disease in pediatric onset systemic lupus erythematosus 显示文摘 | Buratti S Szar IS Spencer CH | 2001 | J Rheumatol2001，28，9： | 1 |
| 19 | Adaptive analysis of thermal comfort in university classrooms: correlation between experimental data and mathematical models 显示文摘 | Buratti C Ricciardi P | 2009 | Building and Environment2009，44，4： | 1 |
| 20 | Relative difference families with variable block sizes and their related OOCs 显示文摘 | BURATTI M WEI Y WU D | 2011 | IEEE Trans Inform Theory2011，57，： | 1 |
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