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| 1 | Comparative clinical study of ultrasound-guided A1 pulley release vs open surgical intervention in the treatment of trigger finger显示文摘AIM To investigate the effectiveness of ultrasound-guided release of the first annular pulley and compare results with the conventional open operative technique.METHODS In this prospective randomized, single-center, clinical study, 32 patients with trigger finger or trigger thumb, grade Ⅱ-Ⅳ according to Green classification system, were recruited. Two groups were formed; Group A(16 patients) was treated with an ultrasound-guided percutaneous release of the affected A1 pulley under local anesthesia. Group B(16 patients) underwent an open surgical release of the A1 pul ey, through a 10-15 mm incision. Patients were assessed pre- and postoperatively(follow-up:2,4 and 12 wk) by physicians blinded to the procedures. Treatment of triggering(primary variable of interest) was expressed as the 'success rate' per digit. The time for taking postoperative pain killers, range of motion recovery, QuickD ASH test scores(Greek version), return to normal activities(including work), complications and cosmetic results were assessed.RESULTS The success rate in group A was 93.75%(15/16) and in group B 100%(16/16). Mean times in group A patients were 3.5 d for taking pain killers, 4.1 d for returning to normal activities, and 7.2 and 3.9 d for complete extension and flexion recovery, respectively. Mean Quick DASH scores in group A were 45.5 preoperatively and, 7.5, 0.5 and 0 after 2, 4, and 12 wk postoperatively. Mean times in group B patients were 2.9 d for taking pain killers, 17.8 d for returning to normal activities, and 5.6 and 3 d for complete extension and flexion recovery. Mean QuickD ASH scores in group B were 43.2 preoperatively and, 8.2, 1.3 and 0 after 2, 4, and 12 wk postoperatively. The cosmetic results found excellent or good in 87.5%(14/16) of group A patients, while in 56.25%(9/16) of group B patients were evaluated as fair or poor.CONCLUSION Treatment of the trigger finger using ultrasonography resulted in fewer absence of work days, and better cosmetic results, in comparison with the open surgery technique. It is a promising method that represents excellent results without major complications, so that it could be possibly be established as a first-line treatment in the trigger finger's disease. | Vasileios S Nikolaou Michael-Alexander Malahias Maria-Kyriaki Kaseta Ioannis Sourlas George C Babis | 2017 | World Journal of Orthopedics2017，8，2： | 14 |
| 2 | Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG显示文摘Two recently engineered SpCas9 variants, namely xCas9 and Cas9-NG, show promising potential in improving targeting specificity and broadening the targeting range. In this study, we evaluated these Cas9 variants in the model and crop plant, rice. We first tested xCas9-3.7, the most effective xCas9 variant in mammalian cells, for targeted mutagenesis at 16 possible NGN PAM (protospacer adjacent motif) combinations in duplicates. xCas9 exhibited nearly equivalent editing efficiency to wild-type Cas9 (Cas9-WT) at most canonical NGG PAM sites tested, whereas it showed limited activity at non-canonical NGH (H = A, C, T) PAM sites. High editing efficiency of xCas9 at NGG PAMs was further demonstrated with C to T base editing by both rAPOBECI and PmCDAI cytidine deaminases. With mismatched sgRNAs, we found that xCas9 had improved targeting specificity over the Cas9-WT. Furthermore, we tested two Cas9-NG variants, Cas9-NGv1 and Cas9-NG, for targeting NGN PAMs. Both Cas9-NG variants showed higher editing efficiency at most non-canonical NG PAM sites tested, and enabled much more efficient editing than xCas9 at AT-rich PAM sites such as GAT, GAA, and CAA. Nevertheless, we found that Cas9-NG variants showed significant reduced activity at the canonical NGG PAM sites. In stable transgenic rice lines, we demonstrated that Cas9-NG had much higher editing efficiency than Cas9-NGv1 and xCas9 at NG PAM sites. To expand the base-editing scope, we developed an efficient C to T base-editing system by making fusion of Cas9-NG nickase (D10A version), PmCDAI, and UGI. Taken together, our work benchmarked xCas9 as a high-fidelity nuclease for targeting canonical NGG PAMs and Cas9-NG as a preferred variant for targeting relaxed PAMs for plant genome editing. | Zhaohui Zhong Simon Sretenovic Qiurong Ren Lijia Yang Yu Bao Caiyan Qi Mingzhu Yuan Yao He Shishi Liu Xiaopei Liu Jiaheng Wang Lan Huang Yan Wang Dibin Baby David Wang Tao Zhang Yiping Qi Yong Zhang | 2019 | Molecular Plant2019，12，7： | 13 |
| 3 | Common controversies in total knee replacement surgery: Current evidence显示文摘Total knee replacement(TKR) is a widely used operation that has radically improved the quality of life of millions of people during the last few decades. However, some technical details, concerning the surgical procedure and the rehabilitation following total knee arthroplasty, are still a matter of a strong debate. In this review of the literature, we have included the best evidence available of the last decade, in an effort to shed light on some of the most controversial subjects related to TKR surgery. Posterior-stabilized or cruciate-retaining prosthesis? To use a tourniquet during operation or not? Do patients need continuous passive motion for their post-surgery rehabilitation? To resurface patella or not? These are some of the most controversial topics that until now have been persistent dilemmas for the orthopedic surgeon. Results of this systematic review of the literature are highly controversial. These conflicting results are an indication that larger and more well conducted high quality trials are needed in order to gain more secure answers. At the same time, it is becoming apparent that a meticulous operative technique, respecting the soft tissue envelope and knowing the principles of alignment and soft tissue balancing, aresome of the parameters that might contribute more to achieving the optimal results for the patients. | Vasileios S Nikolaou Dimitrios Chytas George C Babis | 2014 | World Journal of Orthopedics2014，5，4： | 9 |
| 4 | Management bone loss of the proximal femur in revision hip arthroplasty: Update on reconstructive options显示文摘The number of revision total hip arthroplasties is expected to rise as the indications for arthroplasty will expand due to the aging population. The prevalence of extensive proximal femoral bone loss is expected to increase subsequently. The etiology of bone loss from the proximal femur after total hip arthroplasty is multifactorial. Stress shielding, massive osteolysis, extensive loosening and history of multiple surgeries consist the most common etiologies. Reconstruction of extensive bone loss of the proximal femur during a revision hip arthroplasty is a major challenge for even the most experienced orthopaedic surgeon. The amount of femoral bone loss and the bone quality of the remaining metaphyseal and diaphyseal bone dictate the selection of appropriate reconstructive option. These include the use of impaction allografting, distal press-fit fixation, allograft-prosthesis composites and tumor megaprostheses. This review article is a concise review of the current literature and provides an algorithmic approachfor reconstruction of different types of proximal femoral bone defects. | Vasileios I Sakellariou George C Babis | 2014 | World Journal of Orthopedics2014，5，5： | 5 |
| 5 | Extragastric M anifestations of H elicobacter pylori I nfection显示文摘 | Marko Bani? Francesco Franceschi Zarko Babi? Antonio Gasbarrini | 2012 | Helicobacter2012，，： | 3 |
| 6 | Dextran-modified iron oxide nanoparticles显示文摘Dextran-modified iron oxide nanoparticles were prepared by precipitation of Fe(Ⅱ) and Fe(Ⅲ) salts with ammonium hydroxide by two methods. Iron oxide was precipitated either in the presence of dextran solution, or the dextran solution was added after precipitation. In the second method, the iron oxide particle size and size distribution could be controlled depending on the concentration of dextran in the solution. The nanoparticles were characterized by size-exclusion chromatography, transmission electron microscopy and dynamic light scattering. Optimal conditions for preparation of stable iron oxide colloid particles were determined. The dextran/iron oxide ratio 0-0.16 used in precipitation of iron salts can be recommended for synthesis of nanoparticles suitable for biomedical applications, as the colloid does not contain excess dextran and does not coagulate. | Jií Hradil Alexander Pisarev Michal Babi Daniel Hork | 2007 | China Particuology2007，5，1： | 2 |
| 7 | Elevated serum values of procollagen Ⅲ peptide (PIIIP)in patients with ulcerative colitis who will develop pseudopolyps显示文摘AIM: To assess the impact of procollagen Ⅲ peptide as a marker of collagenesis in the development of pseudopolyps in patients with ulcerative colitis.METHODS: Development of pseudopolyps was monitored in 25 patients with ulcerative colitis classified according to Powell-Tuck index as mild (n=12) or moderate (n=13) form of disease. Patients with a mild form of disease were treated with oral mesalazine medication (2-4 g/day) and local mesalazine preparation (suppository). Patients with a moderate form of disease received oral mesalazine medication (2-4 g/day), local mesalazine preparation(suppository) and local methylprednisolone at an initial dose of 60 rag/day, followed by dose tapering. How many significant variables (previously determined by analysis of variance) were elevated in the groups with and without pseudopolyp developement was observed. ROC analysis for calculation of new index was made.RESULTS: Serum values of procollagen Ⅲ peptide (PⅢP), C-reactive protein (CRP) and C4 complement component (C4)were statistically significantly lower in the group of patients flee from pseudopolyp development bhan bhose who developed one or more pseudopolyps (0.45±0.12 vs 1.42±0.70,P<0.0027; 7.6±4.7 vs 17.8±9.17, P<0.035, and 0.46±0.11 vs 0.34±0.16, P<0.068, respectively) at endoscopic conrtrols with patohistologically samples during 13 months. There were no statistically significant differences in the values of C3, ceruloplasmin and IgM between the two groups (P>0.05).Discrimination function analysis yielded highest standardized cannon coefficients for PⅢP (0.876), CRP (0.104), C3 (-0.534) and C4 (0.184) (P<0.036). The elevation in two of three laboratory variables (PⅢP, CRP and C4) reached sensitivity of 93 % and specificity of 90 % in the development of pseudopolyps.CONCLUSION: It is proposed that an increase in two of the three laboratory parameters (PⅢP, CRP and C4) could improve the accuracy of prediction of the development of pseudopolyps. When using PⅢP, CRP and C4 on decision making, the positive predictive value and accuracy were 90 % and 92 %, respectively. | ■arko Babi Vjekoslav Jagi Zvonko Petrovi Ante Bili KapetanoviDinko Goranka Kubat Rosana Troskot Mira Vukeli | 2003 | World Journal of Gastroenterology2003，9，3： | 2 |
| 8 | Bacteriocin from Bacillus subtilis as a novel drug against diabetic foot ulcer bacterial pathogens显示文摘Objective:To isolate and identify Bacillus subtilis(B.subtilis)from soil and to characterize and partially purify the bacteriocin.To evaluate the antimicrobial activity against four diabetic foot ulcer bacterial pathogens.Methods:Genotypic identification was done based on Sergey's manual of systemic bacteriology.Antimicrobial susceptibility test was done by Kirby-Bauer disc diffusion method.Colonies were identified by colony morphology and biochemical characterization and also compared with MTCC 121 strain.Further identification was done by 16S rRNA sequencing.Inhibitory activities of partially purified bacteriocin on all the DFU isolates were done by agar well diffusion method.The strain was identified to produce bacteriocin by stab overlay assay.Bacteriocin was extracted by organic solvent extraction using chloroform,further purified by HPI.C and physical,and chemical characterization was performed.Results:The four isolates showed high level of resistance to amoxyclav and sensitivity to ciprofloxacin.HPLC purification revealed that the extracts are bacteriocin.The phylogenetic tree analysis results showed that the isolate was 99%related to B.subtilis BSF01.The results reveled activity to all the four isolates and high level of activity was seen in case of Klebsiella sp.Conclusions:Partially purified bacteriocin was found to have antimicrobial activity against the four diabetic foot ulcer bacterial pathogens,which can thus be applied as a better drug molecule on further studies.The strain B.subtilis are found to be safe for use and these antimicrobial peptides can be used as an antimicrobial in humans to treat DFU bacterial pathogens. | Baby Joseph Berlina Dhas Vimalin Hena Justin Raj | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，12： | 2 |
| 9 | Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice显示文摘 | Yi-Xin Wang Valdeci da Cunha Baby Martin-McNulty Jon Vincelette Weiwei Li David F. Choy Meredith Halks-Miller Mithra Mahmoudi Miriam Schroeder Anthony Johns David R. Light William P. Dole | 2005 | European Journal of Pharmacology2005，，2： | 2 |
| 10 | Time-of-flight diffraction (TOFD) technique for accurate sizing of surface-break- ing cracks 显示文摘 | Baby S Balasubramanian T Pardikar R J | 2003 | Insight: Non-Destructive Testing and Condition Monitoring2003，45，6： | 1 |
| 11 | The effectiveness of two COX-2inhibitors in the prophylaxis against heterotopic new bone formation:an experimental study in rabbits显示文摘 | Tsailas PG Babis GC Nikolopoulos K | 2009 | J Surg Res2009，151，1： | 1 |
| 12 | Evaluation of two surgical techniques for acetabular reconstruction in total hip replacement for congenital hip disease: results after a minimum ten-year follow-up显示文摘 | Hartofilakidis G Georgiades G Babis GC | 2008 | J Bone Joint Surg Br2008，90，6： | 1 |
| 13 | High energy tibial plateau fractures treated with hybrid external fixation显示文摘 | Babis GC Evangelopoulos DS Kontovazenitis P | 2011 | J Orthop Surg Res2011，6，1： | 1 |
| 14 | A cholesterol biosensor based on gold nanoparticles decorated functionalized graphene nanoplatelets显示文摘 | Aravind Sasidharan Sasikala Jyothirmayee Baby Aravind Tessy Theres Arockiadoss Thevasahayam | 2011 | Thin Solid Films2011，519，： | 1 |
| 15 | Pulmonary arterial hypertension: Advances in pathophysiology and management显示文摘 | Chopra S Badyal DK Baby PC | 2012 | IndianJ Pharmacol2012，44，1： | 1 |
| 16 | Apoptosis in osteoarthritis: morphology, mechanisms and potential means for therapeutic interven- tion显示文摘 | Johnson EO Charchandi A Babis GC | 2008 | J Surg Orthop Adv2008，17，3： | 1 |
| 17 | The International Neonatal Network 显示文摘 | The CRIB (clinical risk index for babies) score: a tool for asses- sing initial neonatal risk and comparing performance of neonatal intensive care units | 1993 | Lancet1993，342，8865： | 1 |
| 18 | Results ofsurgical treatment of tibial plafond fractures 显示文摘 | Babis GC vayanos ED Papaionnoun | 1997 | Clin Orthop RelatRes1997，341，： | 1 |
| 19 | Time-of-flight dif- fraction technique for accurate sizing of surface breaking cracks 显示文摘 | Balasubramanium T Baby S Pardikar R J | 2003 | Insight2003，45，5： | 1 |
| 20 | Spectroelectrochemical studies of protective surface films against copper corrosion 显示文摘 | Babié R Metikosoe - Hukovic M | 2000 | Thin Solid Films2000，359，1： | 1 |
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