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| 1 | 局部和全身给药后泼尼松龙在外淋巴液中的浓度分析显示文摘目的 :比较局部和全身给药后 2 1 氢化琥珀酸 泼尼松龙在外淋巴液中的药物动力学。方法 :将实验豚鼠分组 ,局部用药 (局部组 ) :将 0 .5 %的 2 1 氢化琥珀酸 泼尼松龙液在直视下置于圆窗龛 ;全身用药 (全身组 ) :按 6 0mg/kg腹腔内注药 ;两组均以生理盐水作为对照。分别于给药后不同时间段采集外淋巴液标本 ,采用高压液相色谱法 (HPLC)测定药物浓度。结果 :局部组药物最高浓度出现在给药后 180min ,为 (95 2 .3± 382 .7)mg/L ,并在 96 0min后维持在 (18.72± 16 .97)mg/L。全身组药物最高峰时间在给药后 15 0min ,为 (14 .71± 7.0 5 )mg/L。结论 :局部给予 2 1 氢化琥珀酸 泼尼松龙 ,可以获得长时间、高浓度的药物水平。 | 苏纪平 Bachmann G 唐安洲 Zumegen C Michel O Wittekindt C | 2003 | 临床耳鼻咽喉科杂志2003，17，10： | 16 |
| 2 | Cachexia and pancreatic cancer: Are there treatment options?显示文摘Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma(PDAC)and is associated with reduced survival and quality of life.Unfortunately,the therapeutic options of this multi-factorial and complex syndrome are limited.This is due to the fact that,despite extensive preclinical and clinical research,the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood.Furthermore,there is still a lack of consensus on the definition of cachexia,which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature.In order to provide an efficient therapy for cachexia,an early and reliable diagnosis and consistent monitoring is required,which can be challenging especially in obese patients.Although many substances have been tested in clinical and preclinical settings,so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia.However,recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancerassociated cachexia and ultimately improve patients’outcome.In this current review,we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients.This strategy consists of nutritional,dietary,pharmacological,physical and psychological methods. | Tara C Mueller Marc A Burmeister Jeannine Bachmann Marc E Martignoni | 2014 | World Journal of Gastroenterology2014，20，28： | 3 |
| 3 | Exploiting Mani- {old Geometry in Hyperspectral Imagery显示文摘 | Bachmann C M Ainsworth T L | 2005 | 1EEE Transactions on Geoscience and Remote Sensing2005，43，： | 1 |
| 4 | Desulfurization of model FCC feedstocks by alkylation:Transformation of thiophenic compounds in presence of 2-methyl-1-pentene over acidic zeolites显示文摘 | DUPUY B LAFORGE S BACHMANN C MAGNOUX P RICHARD F | 2012 | J Mol Catal A:Chem2012，，： | 1 |
| 5 | Unsu- pervised BCM projection pursuit algorithms for classification of simulated radar presentation显示文摘 | BACHMANN C M MUSMAN S A LUONG D etal | 1994 | Neural Networks1994，7，4： | 1 |
| 6 | Visibility : Science and Regulation显示文摘 | CHOW J C BACHMANN J D WIERMAN S S G | 2002 | Journal of the Air and Waste Management Association2002，52，9： | 1 |
| 7 | Comparison of fluorode oxyglucose positron emission tomography and'conventional diagnostic procedures'for the detetion of distant metastases in breast cancer patient显示文摘 | Dose J Bleckmann C Bachmann S | 2002 | Nucl Med Commun2002，23，9： | 1 |
| 8 | The effects of oral N- acetylcysteine in chronic bronchitis: a quantitative systematic review显示文摘 | Stey C Steurer J Bachmann S | 2000 | Eur Respir J2000，16，2： | 1 |
| 9 | The value of B-mode and colour Doppler sonography in the diagnosis of focal splenic lesions显示文摘 | Bachmann C G rg C | 2004 | Uhraschall Ned2004，25，6： | 1 |
| 10 | Temperature quenching of yellow Ce3+ luminescence in YAG:Ce显示文摘 | Bachmann V Ronda C Meijerink A | | 0，，10： | 1 |
| 11 | A new model of reversible sinus sagittalis superior thrombosis in the rat: Magnetic resonance imaging changes显示文摘 | Rottger C Bachmann G Gerriets T | 2005 | Neurosurgery2005，57，3： | 1 |
| 12 | Unsupervised BCM projection pursuit algorithms for classification of simulated radar presentation 显示文摘 | Bachmann C M Musman S A Luong D | 1994 | Neural Networks1994，7，4： | 1 |
| 13 | Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation of 10,654 patients显示文摘 | Reich O Gratzke C Bachmann A | 2008 | J Urol2008，180，： | 1 |
| 14 | Large variability of aripiprazole and dehydroaripi- prazole serum concentrations in adolescent patients with schizo- phrenia显示文摘 | BACHMANN C J RIEGER GIES A HEINZEL GUTENBRUN- NER M | 2008 | Ther Drug Monit2008，30，4： | 1 |
| 15 | Exploiting mani- fold geometry in hyperspectral imagery显示文摘 | Bachmann C M Ainsworth T L Fusina R A | 2005 | IEEE Transactions on Geoscienee and Remote Sensing2005，43，3： | 1 |
| 16 | Expert consensus document on the use of antiplatelet agents 显示文摘 | Patrono C Bachmann F Baigent C | 2004 | Eur Heart J2004，25，2： | 1 |
| 17 | Visibility : science and regulation 显示文摘 | Chow J C Bachmann J D | 2002 | Journal of the Air & Waste Management Association2002，52，9： | 1 |
| 18 | Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty:an evidence-based meta-analysis显示文摘 | Bachmann B Taylor RS Cursiefen C | 2010 | Ophthalmology2010，117，7： | 1 |
| 19 | Oral immunization with urease and Escherichia coli heatlabile enterotoxin is safe and immunogenic in Heliobacter pylori-infected adults 显示文摘 | Michetti P Kreiss C Kotloff KL Pota N Bachmann D Herranz M | 1999 | Gastroenterology1999，116，4： | 1 |
| 20 | Comparison of fluorodeoxyglucose positron emis-sion tomography and 'conventional diagno stic procedures' for the detection of distant metastases in breast cancer patients显示文摘 | Dose J Bleckmann C Bachmann S | 2002 | Nucl Med Common2002，23，9： | 1 |
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