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| 1 | NIHSS绝对值变化与NIHSS变化率对脑梗死患者残疾预测能力的比较研究显示文摘目的探讨美国国立卫生研究院卒中量表(NIHSS)绝对值的变化与NIHSS变化率对脑梗死患者功能残疾的预测价值。方法采用前瞻性设计对10个临床研究中心急性期脑梗死患者的数据进行分析,筛选出入院当天、发病90d NIHSS评分和BI数据资料完整患者953例,按入院时NIHSS评分分为轻、中、重度,以BI作为功能残疾疗效判定'金标准',应用ROC比较NIHSS绝对值变化与NIHSS变化率对患者功能残疾的判断价值。结果轻、中、重度患者AUC曲线下面积分别为0.60、0.76、0.93,与AUC曲线下面积=0.50比较,中、重度患者差异有统计学意义(P<0.05)。NIHSS变化率在轻、中、重度患者中分别为0.76、0.85、0.97,与AUC曲线下面积=0.50比较,差异均有明显统计学意义(P<0.01)。脑梗死患者良好功能结局的最佳NIHSS绝对值变化的界值在轻、中、重度患者中分别为2.5、4.5、14.5;敏感性分别为0.57、0.92、1.00,特异性分别为0.61、0.50、0.89;NIHSS变化率的界值在轻、中、重度患者中分别为70.8%、74.7%、84.9%;敏感性分别为0.63、0.82、1.00,特异性分别为0.78、0.75、0.94。结论 NIHSS绝对值变化、NIHSS变化率对患者功能残疾的预测能力随着神经功能缺损程度的增加而增大,而后者对结局预测能力更佳。 | 王平平 高颖 刘璐 马斌 曹克刚 辛喜艳 张杨 ShaPour Badiee Aval Baghyahi | 2011 | 中风与神经疾病杂志2011，28，2： | 52 |
| 2 | 口服消炎痛和布洛芬治疗早产儿动脉导管未闭的比较显示文摘目的静脉注射消炎痛是早产儿动脉导管未闭的常规治疗方法,但治疗过程中常出现一些副作用,如少尿、消化道出血、脑血流灌注减少。近年来,静脉注射布洛芬已用于治疗早产儿动脉导管未闭。布洛芬治疗不会减少脑血流灌注,也不会影响胃肠道和肾脏的血流动力学。伊朗目前尚无消炎痛和布洛芬的静脉制剂供应。该研究旨在比较这两种药的口服制剂治疗早产儿动脉导管未闭的疗效和安全性。方法36例胎龄小于34周经超声心动图确诊患有动脉导管未闭的早产儿被随机分为两组,每组18人。一组给予消炎痛口服,每次0.2mg/kg,24h给药1次,共3次。另一组给予布洛芬口服,共3次,间隔时间为24h,首剂为10mg/kg,随后两次各5mg/kg。用药后观察导管闭合率、副作用、并发症及临床过程。结果用药后布洛芬组18例患儿动脉导管都闭合(100%),而消炎痛组18例中有15例患儿动脉导管闭合(83.3%)(P〉0.05)。两组疗效差异统计学无显著性意义。治疗前后两组的血清尿素氮和肌酐含量差异也无显著性意义。消炎痛组发生了3例(16.6%)坏死性小肠结肠炎,布洛芬组则无,差异有显著性意义(P〈0.05)。治疗1个月后两组成活率均为94%(17/18)。消炎痛组1例死于坏死性小肠结肠炎,布洛芬组1例死于败血症。结论口服布洛芬治疗早产儿动脉导管未闭和口服消炎痛治疗一样有效,而且坏死性小肠结肠炎的发生率较口服消炎痛治疗低。 | Saed Hossein FAKHRAEE Zohreh BADIEE Saied MOJTAHEDZADEH Mohammad KAZEMIAN Roya KELISHADI Shahid Beheshti | 2007 | 中国当代儿科杂志2007，9，5： | 11 |
| 3 | Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization显示文摘For efficient mucosal vaccine delivery, nanoparticulate antigens are better taken by microfold cells in the nasal associated lymphoid tissue and also dendritic cells. Nanoparticles based on polymers such as chitosan(CHT) and its water soluble derivative, trimethylchitosan(TMC), could be successfully used as carrier/adjuvant for this purpose. Sodium alginate, a negatively charged biopolymer, could modify the immunostimulatory properties of CHT and TMC NPs and increase their stability. Sodium alginate(ALG)-coated chitosan(CHT)and trimethylchitosan(TMC) nanoparticles(NPs) loaded with inactivated PR8 influenza virus were successfully prepared by direct coating of the virus with CHT or TMC polymers to evaluate their immunoadjuvant potential after nasal immunization. After nasal immunizations in BALB/c mice, PR8-CHT formulation elicited higher IgG2 a and Ig G1 antibody titers compared with PR8-TMC. ALG coating of this formulation(PR8-CHT-ALG) significantly decreased the antibody titers and a less immune response was induced than PR8-TMC-ALG formulation. PR8-TMC-ALG formulation showed significantly higher Ig G2 a/Ig G1 ratio, as criteria for Th1-type immune response, compared with PR8-CHT-ALG and PR8 virus alone. Altogether, the PR8-TMC-ALG formulation could be considered as an efficient intranasal antigen delivery system for nasal vaccines. | Jafar Mosafer Amir-Hossein Sabbaghi Ali Badiee Solmaz Dehghan Mohsen Tafaghodi | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 2 |
| 4 | ROC曲线分析NIHSS的变化率预测脑梗死患者功能残疾的可行性显示文摘目的通过对美国国立卫生研究院卒中量表(NIHSS)评分变化率的分析试图为脑梗死临床结局评价方法的选择提供一种新的思路与方法。方法本项研究采取前瞻性设计对来自10个临床研究中心急性期脑梗死住院患者的数据内容进行分析,筛选出入院当天NIHSS评分、发病90 d NIHSS评分和BI数据资料完整患者953例,将患者按入院时NIHSS评分分为3级:轻度(〈7分)、中度(7分-15分)、重度(〉15分),以BI作为功能残疾的疗效判定"金标准",发病90 d BI≥95分为预后良好、BI〈95分为预后不良的分界点将BI转换为二分类变量(残疾与否),应用ROC曲线了解NIHSS的变化率对脑梗死患者发病90天功能残疾的判断价值。结果本研究发现NIHSS变化率预测脑梗死患者发病90 d功能残疾的AUC曲线下面积均〉0.70,轻度患者为0.76、中度患者为0.85,重度患者为0.97,与AUC曲线下面积=0.50进行比较,差异有统计学意义(P≤0.001)。预测脑梗死患者良好功能结局的最佳NIHSS变化率的截断值在轻度、中度、重度神经功能缺损的患者分别为70.8%、74.7%、84.9%;其灵敏度在三者分别为63.0%、81.8%、100.0%,特异度分别为78.1%、75.4%、94.3%。结论 NIHSS的变化率对脑梗死患者发病90 d功能残疾具有较好的预测能力,且这种预测能力随着神经功能缺损程度的增加而增大。 | 王平平 高颖 刘璐 马斌 曹克刚 辛喜艳 Shapour Badiee Aval Baghyahi | 2011 | 中西医结合心脑血管病杂志2011，9，4： | 2 |
| 5 | Biotransformation of methyltestosterone by the flamentous fungus Mucor racemosus显示文摘 | TORSHABI M BADIEE M FARAMARZI M A | 2011 | Chemistry of Natural Compounds2011，47，1： | 1 |
| 6 | Cord blood lipid profile and associated factors:baseline data of a birth cohort study显示文摘 | Kelishadi R Badiee Z Adeli K | 2007 | Paediatr Perinat Epidemiol2007，21，6： | 1 |
| 7 | Invasive fungal infections in renal transplant recipxents显示文摘 | Badiee P Alborzi A | 2011 | Exp Clin Transplant2011，9，6： | 1 |
| 8 | CD4 nadir is apredictor of HIY neurocognitive impairment in the era ofcombination antiretroviral therapy 显示文摘 | Ellis RJ Badiee J Vaida F | 2011 | AIDS2011，25，14： | 1 |
| 9 | An algorithm for predicting the hydrodynamic and mass transfer parameters in agitated reactors显示文摘 | Romain Lemoine Badie I. Morsi | 2005 | Chemical Engineering Journal2005，，1： | 1 |
| 10 | Single institution experience treating 104 vestibular schwannomas with fractionated stereotactic radiation therapy or stereotactic radiosurgery显示文摘 | Bethany M. Anderson Deepak Khuntia S?ren M. Bentzen Heather M. Geye Lori L. Hayes John S. Kuo Mustafa K. Baskaya Behnam Badie Amar Basavatia G. Mark Pyle Wolfgang A. Tomé Minesh P. Mehta | 2014 | Journal of Neuro-Oncology2014，，： | 1 |
| 11 | Optimization of a method toprepare liposomes containing HER2/Neu - derived peptide as avaccine delivery system for breast cancer显示文摘 | Shariat S Badiee A’Jaafari MR | 2014 | Iran J Pharm Res2014，，： | 1 |
| 12 | Album in cobalt binding assay to rule out acute coronary syndrome显示文摘 | Badie J M Blassinggame C L Bankson D D | | 0，，01： | 1 |
| 13 | Invasive fungal infections in re- nal transplant recipients 显示文摘 | Badiee P Alborzi A | 2011 | Exp Clin Transplant2011，9，6： | 1 |
| 14 | Prospective screening in liver transplant recipients by panfungal PCR-ELISA for early diagnosis of invasive fungal infections显示文摘 | Badiee P Kordbacheh P Alborzi A | 2007 | Liver Transpl2007，13，7： | 1 |
| 15 | P5 HER2/neu - derived pep-tide conjugated to liposomes containing MPL adjuvant as an effec-tive prophylactic vaccine formulation for breast cancer 显示文摘 | Shariat S Badiee A Jalali SA | 2014 | CancerLett2014，355，1： | 1 |
| 16 | Cord blood lipid profile and as- sociated factors: baseline data of a birth cohort study显示文摘 | Kelishadi R Badiee Z Adeli K | 2007 | Paediatr Perinat Epidemiol2007，21，6： | 1 |
| 17 | Fungal infections in solid organ recipients显示文摘 | Badiee P Kordbacheh P Alborzi A | 2005 | Exp Clin Transplant2005，3，2： | 1 |
| 18 | Profound influence of microarray scanner characteristics on gene expression ratios:analysis and procedure for correction显示文摘 | Lyng H Badiee A Svendsrud DH | 2004 | BMC Genomics2004，5，1： | 1 |
| 19 | The effects of low level laser in clinical outcome and neurophysiologieal results of carpal tunnel syndrome 显示文摘 | Shooshtari SMJ Badiee V Taghizadeh SH | 2008 | Electromyogr Clin Neurophysiol2008，48，5： | 1 |
| 20 | Invasive fungal infections in renal transplant recipients 显示文摘 | BADIEE P ALBORZ I | 2011 | Exp Clin Transplant2011，9，6： | 1 |
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