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| 1 | Growth-Defense Tradeoffs in Plants: A Balancing Act to Optimize Fitness显示文摘 | Bethany Huot Jian Yao Beronda L. Montgomery' Sheng Yang He | 2014 | Molecular Plant2014，7，8： | 37 |
| 2 | Disruptions in AUXl-Dependent Auxin Influx Alter Hypocotyl Phototropism in Arabidopsis显示文摘 | Bethany B. Stonea Emily L. Stowe-Evans Reneé M. Harper R. Brandon Celaya Karin Ljung Goran Sandbergc Emmanuel Liscum | 2008 | Molecular Plant2008，1，1： | 13 |
| 3 | Comparison of the diagnostic yield and outcomes between standard 8 h capsule endoscopy and the new 12 h capsule endoscopy for investigating small bowel pathology显示文摘AIM: To evaluate the completion rate and diagnostic yield of the Pill Cam SB2-ex in comparison to the Pill Cam SB2.METHODS:Two hundred cases using the 8-h Pill Cam SB2 were retrospectively compared to 200 cases using the 12 h Pill Cam SB2-ex at a tertiary academic center.Endoscopically placed capsules were excluded from the study.Demographic information,indications for capsule endoscopy,capsule type,study length,completion of exam,clinically significant findings,timestamp of most distant finding,and significant findings beyond 8 h were recorded.RESULTS:The 8 and 12 h capsule groups were well matched respectively for both age(70.90±14.19vs 71.93±13.80,P=0.46)and gender(45.5%vs48%male,P=0.69).The most common indications for the procedure in both groups were anemia and obscure gastrointestinal bleeding.Pill Cam SB2-ex had a significantly higher completion rate than Pill Cam SB2(88%vs 79.5%,P=0.03).Overall,the diagnostic yield was greater for the 8 h capsule(48.5%for SB2vs 35%for SB2-ex,P=0.01).In 4/70(5.7%)of abnormal SB2-ex exams the clinically significant findingwas noted in the small bowel beyond the 8 h mark.CONCLUSION:In our study,we found the Pill Cam SB2-ex to have a significantly increased completion rate,though without any improvement in diagnostic yield compared to the Pill Cam SB2. | Merajur Rahman Stuart Akerman Bethany De Vito Larry Miller Meredith Akerman Keith Sultan | 2015 | World Journal of Gastroenterology2015，21，18： | 12 |
| 4 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 5 | Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth显示文摘 | Michael Quante Shui Ping Tu Hiroyuki Tomita Tamas Gonda Sophie S.W. Wang Shigeo Takashi Gwang Ho Baik Wataru Shibata Bethany DiPrete Kelly S. Betz Richard Friedman Andrea Varro Benjamin Tycko Timothy C. Wang | 2011 | Cancer Cell2011，，2： | 4 |
| 6 | Disruption of Arabidopsis CHY1 Reveals an Important Role of Metabolic Status in Plant Cold Stress Signaling显示文摘到学习寒冷发信号,我们与 CBF3 倡导者(CBF3-LUC ) 驾驶的萤火虫酶记者基因的改变的导致寒冷的抄写为 Arabidopsis 屏蔽了异种。一异种, chy1-10,显示减少 CBF3-LUC 冷正式就职光。RNA 胶化污点分析表明内长的 CBF 的那表情也在 chy1 异种被减少。chy1-10 异种植物对冻结处理比更敏感在冷环境适应以后野类型。两野类型并且 chy1 异种植物对在温暖的温度的导致黑暗的饥饿敏感,尽管 chy1 植物是稍微更敏感的。这黑暗敏感被冷温度压制在野类型然而并非在 chy1。组成的 CBF3 表示部分在寒冷救 chy1-10 植物的敏感到黑暗处理。chy1 异种积累 CBF3-LUC 冷正式就职的氢过氧化物罐头还原剂的反应的氧种类,和申请的高水平在野类型。在异种的基因有缺陷者的基于地图的克隆在 CHY1 揭示了一个胡说八道变化,它编码 CoA hydrolase 为缬氨酸分解代谢和丰满的酸氧化需要的 peroxisomal -hydroxyisobutyryl (HIBYL ) 。我们的结果在冷应力发信号为 peroxisomal 新陈代谢建议一个角色,并且种忍耐到冷应力和导致黑暗的饥饿。 | Chun-Hai Dong Bethany K. Zolman Bonnie Bartel Byeong-ha Lee Becky Stevenson Manu Agarwal Jian-Kang Zhu | 2009 | Molecular Plant2009，2，1： | 4 |
| 7 | Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults; Food Reintroduction Identifies Causative Factors显示文摘 | Nirmala Gonsalves Guang–Yu Yang Bethany Doerfler Sally Ritz Anne M. Ditto Ikuo Hirano | 2012 | Gastroenterology2012，，： | 3 |
| 8 | Rapid and flexible segmentation of electron microscopy data using few-shot machine learning显示文摘Automatic segmentation of key microstructural features in atomic-scale electron microscope images is critical to improved understanding of structure–property relationships in many important materials and chemical systems.However,the present paradigm involves time-intensive manual analysis that is inherently biased,error-prone,and unable to accommodate the large volumes of data produced by modern instrumentation.While more automated approaches have been proposed,many are not robust to a high variety of data,and do not generalize well to diverse microstructural features and material systems.Here,we present a flexible,semi-supervised few-shot machine learning approach for segmentation of scanning transmission electron microscopy images of three oxide material systems:(1)epitaxial heterostructures of SrTiO_(3)/Ge,(2)La_(0.8)Sr_(0.2)FeO_(3) thin films,and(3)MoO_(3) nanoparticles.We demonstrate that the few-shot learning method is more robust against noise,more reconfigurable,and requires less data than conventional image analysis methods.This approach can enable rapid image classification and microstructural feature mapping needed for emerging high-throughput characterization and autonomous microscope platforms. | Sarah Akers Elizabeth Kautz Andrea Trevino-Gavito Matthew Olszta Bethany E.Matthews Le Wang Yingge Du Steven R.Spurgeon | 2021 | npj Computational Materials2021，，1： | 3 |
| 9 | CT enterography vs. capsule endoscopy显示文摘 | Howard S. Boriskin Bethany S. Devito John J. Hines Victor J. Scarmato Barak Friedman | 2009 | Abdominal Imaging2009，，2： | 2 |
| 10 | 奶牛功能性体型结构的重要性显示文摘体型鉴定是高效奶牛经营生产中一项必需的管理技术。虽然基因组评定可以获得一定的可信信息,但体型结构评定可以证实其遗传预测是否准确。加拿大荷斯坦牛外貌评级咨询委员会建议将髋关节位置作为第24个标准线性评定性状,这一建议已获得加拿大荷斯坦董事会的批准。 | Bethany Muir 邱昌功 | 2012 | 中国奶牛2012，，11： | 2 |
| 11 | Remote ischaemic conditioning for stroke: unanswered questions and future directions显示文摘Remote ischaemic conditioning(RIC)refers to a process whereby periods of intermittent ischaemia,typically via the cyclical application of a blood pressure cuff to a limb at above systolic pressure,confers systemic protection against ischaemia in spatially distinct vascular territories.The mechanisms underlying this have not been characterised fully but have been shown to involve neural,hormonal and systemic inflammatory signalling cascades.Preclinical and early clinical studies have been promising and suggest beneficial effects of RIC in acute ischaemic stroke,symptomatic intracranial stenosis and vascular cognitive impairment.Through systematic searches of several clinical trials databases we identified 48 active clinical trials of RIC in ischaemic stroke,intracerebral haemorrhage and subarachnoid haemorrhage.We summarise the different RIC protocols and outcome measures studied in ongoing clinical trials and highlight which studies are most likely to elucidate the underlying biological mechanisms of RIC and characterise its efficacy in the near future.We discuss the uncertainties of RIC including the optimal frequency and duration of therapy,target patient groups,cost-effectiveness,the confounding impact of medications and the absence of a clinically meaningful biomarker of the conditioning response.With several large clinical trials of RIC expected to report their outcomes within the next 2 years,this review aims to highlight the most important studies and unanswered questions that will need to be addressed before this potentially widely accessible and low-cost intervention can be used in clinical practice. | Sheharyar Baig Bethany Moyle Krishnan Padmakumari Sivaraman Nair Jessica Redgrave Arshad Majid Ali Ali | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 12 | Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair显示文摘Macrophage plasticity is critical for normal tissue repair following injury.In pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are unknown.Here,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene expression.Mechanistically,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling.However,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 mechanism.Interestingly,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound macrophages.STING limits inflammatory cytokine production by wound macrophages during healing.However,in diabetic mice,its role changes to limit wound repair and enhance inflammation.This finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time points.Finally,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING.Taken together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds. | Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 13 | Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα显示文摘 | Daniel J Peet Stephen D Turley Wenzhen Ma Bethany A Janowski Jean-Marc A Lobaccaro Robert E Hammer David J Mangelsdorf | 1998 | Cell1998，，： | 2 |
| 14 | The role of the aryl hydrocarbon receptor in the female reproductive system显示文摘 | Isabel Hernández-Ochoa Bethany N. Karman Jodi A. Flaws | 2008 | Biochemical Pharmacology2008，，4： | 2 |
| 15 | Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults; Food Reintroduction Identifies Causative Factors显示文摘 | Nirmala Gonsalves Guang–Yu Yang Bethany Doerfler Sally Ritz Anne M. Ditto Ikuo Hirano | 2012 | Gastroenterology2012，，7： | 1 |
| 16 | Evaluating implicit spider fear associations using the Go/No-go Association Task显示文摘 | Teachman Bethany A | 2007 | Journal of Behavior Therapy and Experimental Psychiatry2007，38，2： | 1 |
| 17 | Tumor angiogenesis is regulated by CXC ehemokines显示文摘 | Bethany M B Douglas A A Christina A L | 1998 | J laband Clin Med1998，132，： | 1 |
| 18 | Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response显示文摘 | Bethany Hansen Anna Sokolovska Harm HogenEsch Stanley L. Hem | 2007 | Vaccine2007，，36： | 1 |
| 19 | Staying Tuned to Researchin Implicit Cognition: Relevance for Clinical Practice With Anxiety Disorders显示文摘 | Teachman Bethany A Woody Sheila R | 2004 | Cognitive and Behavioral Practice2004，11，2： | 1 |
| 20 | Neutrophil volume distri- bution width:a new automated hematologic parameter for a- cute infection显示文摘 | Fernando C Bethany T Xu DS | 2006 | Arch Pathol Lab Med2006，130，3： | 1 |
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