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| 1 | From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part I显示文摘 | Morteza Naghavi Peter Libby Erling Falk S. Ward Casscells Silvio Litovsky John Rumberger Juan Jose Badimon Christodoulos Stefanadis Pedro Moreno Gerard Pasterkamp Zahi Fayad Peter H. Stone Sergio Waxman Paolo Raggi Mohammad Madjid Alireza Zarrabi Allen Bu | 2003 | Circulation: Journal of the American Heart Association2003，，14： | 6 |
| 2 | Inflammation, lipid metabolism and cardiovascular risk in rheumatoid arthritis: A qualitative relationship?显示文摘Life expectancy in patients with rheumatoid arthritis(RA)is reduced compared to the general population owing to an increase in cardiovascular diseases(CVD)not fully explained by traditional cardiovascular risk factors.In recent years,interest has been focused on the alterations in lipid metabolism in relation to chronic inflammation as one of the possible mechanisms involvedin the pathogenesis of atherosclerosis of RA patients.Research regarding this issue has revealed quantitative alterations in lipoproteins during the acute-phase reaction,and has also demonstrated structural alterations in these lipoproteins which affect their functional abilities.Although many alterations in lipid metabolism have been described in this regard,these structural changes associated with inflammation are particularly important in high-density lipoproteins as they affect their cardioprotective functions.In this respect,excessive oxidation in low-density lipoprotein(LDL)and increased lipoprotein(a)with a predominance of smaller apolipoprotein(a)isoforms has also been reported.This article will discuss proinflammatory high-density lipoproteins(pi HDL),oxidized LDL and lipoprotein(a).Elevated concentrations of these lipoproteins with marked pro-atherogenic properties have been observed in RA patients,which could help to explain the increased cardiovascular risk of these patients. | Carmen García-Gómez Maria Bianchi Diana de la Fuente Lina Badimon Teresa Padró Emili Corbella Xavier Pintó | 2014 | World Journal of Orthopedics2014，5，3： | 4 |
| 3 | From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part II显示文摘 | Morteza Naghavi Peter Libby Erling Falk S. Ward Casscells Silvio Litovsky John Rumberger Juan Jose Badimon Christodoulos Stefanadis Pedro Moreno Gerard Pasterkamp Zahi Fayad Peter H. Stone Sergio Waxman Paolo Raggi Mohammad Madjid Alireza Zarrabi Allen Bu | 2003 | Circulation: Journal of the American Heart Association2003，，15： | 3 |
| 4 | Monocyte-secreted Wnt5a interacts with FZD5 in microvascular endothelial cells and induces angiogenesis through tissue factor signaling显示文摘Angiogenesis 表示特性地与发炎在反应、病理学的过程期间被联系。煽动性的房间由 secreting 参予 angiogenesis 影响 endothelial 房间功能的不同分子。我们以前证明了在激活的 microvascular endothelial 房间(mEC ) 的那导致的织物因素(TF ) 表情能经由 autocrine 规定导致 angiogenesis。然而,在 mEC 导致 TF 表示的信号充分不被知道。这里,我们证明有 mECs 的单核白血球 paracrine 串音触发 mEC-TF 表示。我们鉴别了藏匿单核白血球的 Wnt5a 在 mEC 导致 TF 表示并且机能上地在 vivo 在 vitro 以及 microvessel 形成导致房间单层修理和 angiotube 形成。藏匿单核白血球的 Wnt5a 在 mECs 激活 FZD5,它发信号导致细胞内部的 Ca 2+ 和增加 NFB 抄写活动和 TF 基因表示的版本。简言之,单核白血球分泌的 Wnt5a 在 mECs 通过不在经典中的 WntFZD5 小径发信号导致由 autocrine 规定导致 angiogenesis 的 TF 表示。 | Gemma Arderiu Sonia Espinosa Esther Pena Rosa Aledo Lina Badimon | 2014 | Journal of Molecular Cell Biology2014，8，5： | 3 |
| 5 | The pathogenesis of coronary artery disease and the acute coronary syndromes显示文摘 | Fuster V Badimon L Badimon JJ | 1992 | N Engl J Med1992，326，4： | 2 |
| 6 | Negative feedback control of neuronal activity by microglia显示文摘Microglia,the brain's resident macrophages,help to regulate brain function by removing dying neurons,pruning non-functional synapses,and producing ligands that support neuronal survival1.Here we show that microglia are also critical modulators of neuronal activity and associated behavioural responses in mice.Microglia respond to neuronal activation by suppressing neuronal activity,and ablation of microglia amplifies and synchronizes the activity of neurons,leading to seizures.Suppression of neuronal activation by microglia occurs in a highly region-specific fashion and depends on the ability of microglia to sense and catabolize extracellular ATP,which is released upon neuronal activation by neurons and astrocytes.ATP triggers the recruitment of microglial protrusions and is converted by the microglial ATP/ADP hydrolysing ectoenzyme CD39 into AMP;AMP is then converted into adenosine by CD73,which is expressed on microglia as well as other brain cells.Microglial sensing of ATP,the ensuing microglia-dependent production of adenosine,and the adenosine-mediated suppression of neuronal responses via the adenosine receptor A1R are essential for the regulation of neuronal activity and animal behaviour.Our findings suggest that this microglia-driven negative feedback mechanism operates similarly to inhibitory neurons and is essential for protecting the brain from excessive activation in health and disease. | Ana Badimon | 2020 | 四川生理科学杂志2020，42，4： | 2 |
| 7 | Metabolic syndrome and diabetic atherothrombosis: implications in vascular complications显示文摘 | Meerarani P Badimon J Zias E | 2006 | Curr Mol Med2006，6，： | 1 |
| 8 | The pathogenesis of coronary artery disease and the acute coronary syndromes显示文摘 | Fuster V Badimon L Badimon JJ | 1992 | N Engl J Med1992，326，5： | 1 |
| 9 | Human monocytederived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques显示文摘 | Shah PK Falk E Badimon J J et al | 1995 | Circulation1995，92，： | 1 |
| 10 | Atherothrombosis:mechanisms and clinical therapeutic approaches 显示文摘 | Fuster V Badimon JJ Chesebro JH | 1998 | Vasc Med1998，3，3： | 1 |
| 11 | The pathogenisis of coronary artery disease and the acute coronary syndromes显示文摘 | Fuster V Badimon L Badimon J | 1992 | N Engl J Med1992，326，： | 1 |
| 12 | Atherothrombosis : a widespread disease with unpredictable and life-threatening consequences显示文摘 | Viles-Gonzalez JF Fuster V and Badimon JJ | 2004 | Eur Heart J2004，25，14： | 1 |
| 13 | Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques: potential role of matrix-degrading metalloproteinases and implications for plaque rupture显示文摘 | Shah PK Falk E Badimon JJ | 1995 | Circulation1995，92，6： | 1 |
| 14 | Mitogen-induced p53 downregulation precedes vascular smooth muscle cell migration from healthy tunica media and proliferation显示文摘 | Rodríguez-Campos A Ruiz-Enríquez P Faraudo S Badimon L | 2001 | Arterioscler Thromb Vasc Biol2001，21，2： | 1 |
| 15 | Overcoming restenosis with sirolimus From alphabet soup to clinical reality 显示文摘 | Pooh M Badimon JJ Fuster V | 2002 | Lancet2002，359，9306： | 1 |
| 16 | Human monocyte derived macrophages induce collagen breaddown in fibrous caps of atherosclerotic plaque : Potential role of matrix - degrading metalloproteinases and implications for plaque rupture 显示文摘 | SHAH P K FALK E BADIMON J J | 1995 | Circulation1995，92，6： | 1 |
| 17 | The pathogenesis of coronary artry disease and the acute coronary syndromes显示文摘 | Fuster V Badimon BJJ | 1992 | N Engl J Med1992，26，： | 1 |
| 18 | The pathogenesis of coronary artery disease and the acute coronary syndromes显示文摘 | Fuster V Badimon L Badimon JJ | 1992 | N Engl J Med1992，326，4： | 1 |
| 19 | Dissolution of mural thrombus by specific thrombin inhibition with r- hirudin: comparison with heparin and aspirin 显示文摘 | Meyer BJ Badimon JJ Chesebro JH | 1998 | Circulation1998，97，7： | 1 |
| 20 | Role of high density lipoproteins in the regression of atherosclerosis显示文摘 | Badimon JJ Fuster V Badimon L | 1992 | Circulation1992，86，6： | 1 |
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