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| 1 | Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with crohn's disease显示文摘Mesenchymal stem cells(MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro.It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorders.We present the case of a patient suffering from childhood-onset, multidrug resistant and steroiddependent Crohn's disease who underwent systemic infusions of MSC, which led to a temporary reduction in CCR4, CCR7 and CXCR4 expression by T-cells, and a temporary decrease in switched memory B-cells, In addition, following MSC infusion, lower doses of steroids were needed to inhibit proliferation of the patient's peripheral blood mononuclear cells.Despite these changes, no significant clinical benefit was observed, and the patient required rescue therapy with infliximab and subsequent autologous hematopoietic stem cell transplantation.The results of biological and in vitro observations after MSC use and the clinical effects of infusion are discussed, and a brief description is provided of previous data on MSC-based therapy in autoimmune disorders. | Andrea Taddio Alberto Tommasini Erica Valencic Ettore Biagi Giuliana Decorti Sara De Iudicibus Eva Cuzzoni Giuseppe Gaipa Raffaela Badolato Alberto Prandini Andrea Biondi Alessandro Ventura | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 2 | Hyper immunoglobulin M sydrome due to CD40 deficiency: clinical, molecular, and immunological features 显示文摘 | Lougaris V Badolato R Ferrari S | 2005 | Immunol Rev2005，203，： | 1 |
| 3 | Hyper immunoglobulin M syndrome due to CD40 deficiency:clinical,molecular,and immunological features显示文摘 | Lougaris V Badolato R Ferrari S | | 0，，： | 1 |
| 4 | Quantum-dot spin-state Preparation with Near-unity fidelity显示文摘 | Atature Mete Dreiser Jan Badolato Antonio etal | 2006 | Science2006，312，5773： | 1 |
| 5 | New Insights into the Biology of the Acute Phase Response显示文摘 | Anthony F. Suffredini Giamila Fantuzzi Raffaele Badolato Joost J. Oppenheim Naomi P. O’Grady | 1999 | Journal of Clinical Immunology1999，，4： | 1 |
| 6 | Quantum nature of a strongly coupled single quantum dot- cavity system 显示文摘 | HENNESSY K BADOLATO A WINGER M | 2007 | Nature2007，445，7130： | 1 |
| 7 | Serum amyloid is an activator of PMN antimicrobial functions: induction of degranulation, phagocytosis, and enhancement of anti- Candida activity 显示文摘 | Badolato R Wang JM Stornello SL | 2000 | J Leukoc Biol2000，67，3： | 1 |
| 8 | Serum amyloid A is an activator of PMN antimicrobial functions: induction of degranulation, phagocytosis and enhancement of anti-Candida activity 显示文摘 | Badolato R Wang JM Stomello SL | 2000 | Leukac Biol2000，67，2： | 1 |
| 9 | Clinical and genetic features of warts, hypogammaglobulinemia, infections and myelokathexis (WHIM) syndrome 显示文摘 | Dotta L Tassone L Badolato R | 2011 | Curr Mol Med2011，11，4： | 1 |
| 10 | New insights into the biology of the acute phase response 显示文摘 | Suffredini AF Fantuzzi G Badolato R | 1999 | J Clin Immunol1999，19，4： | 1 |
| 11 | Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes显示文摘 | BADOLATO R PONZI AN MILLESIMO M | 1997 | Blood1997，90，7： | 1 |
| 12 | Clinical and genetic features of Warts,Hypogammaglobulinemia,Infections and Myelokathexis (WHIM) syndrome显示文摘 | Dotta L Tassone L Badolato R | | 0，，04： | 1 |
| 13 | Audit Committee Financial Expertise and Earnings Management:The Role of Status显示文摘 | Badolato P Donelson D C Ege M | 2014 | Journal of Accounting&Economics2014，58，2： | 1 |
| 14 | New Insights into the Biology of the Acute Phase Response显示文摘 | Anthony F. Suffredini Giamila Fantuzzi Raffaele Badolato Joost J. Oppenheim Naomi P. O’Grady | 1999 | Journal of Clinical Immunology1999，，4： | 1 |
| 15 | Square-lattice photonic crystal microcavities for coupling to single InAs quantum dots显示文摘 | HENNESSY K REESE C BADOLATO A | 2003 | Appl Phys Lett2003，83，18： | 1 |
| 16 | A novel biologic function of serum amyloid A:induction of T lymphocyt migration and adhesion显示文摘 | Xu L Badolato R Murphy W J | 1995 | J Immunol1995，155，3： | 1 |
| 17 | Differential expression of surface membrane growth hormone receptor on human peripheral blood lymphocytes by dual fluorochrome flow cytometry显示文摘 | Badolato R Bond HM Valerio G | 1994 | Clin Endocrinol Metab1994，79，： | 1 |
| 18 | Quantum nature of a strongly coupled single quantum dot cavity system显示文摘 | Hennessy K Badolato A Winger M | 2007 | Nature2007，445，： | 1 |
| 19 | Hyper immunoglobulin M sydrome due to CD40 deficiency : clinical, molecular, and im- munological features显示文摘 | Lougaris V Badolato R Ferrari S | 2005 | Immunol Rev2005，203，： | 1 |
| 20 | Evaluation of long term stability of model emulsions by multisample analytical centrifugation 显示文摘 | BADOLATO G G AGUILAR F SCHUCHMANN H P | 2008 | Progress in Colloid Polymer Science2008，134，： | 1 |
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