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| 1 | Diabetic retinopathy and age-related macular degeneration: a survey of pharmacoutilization and cost in Calabria, Italy显示文摘The aged population is constantly growing, thus fostering an increase in age-dependent diseases. Among these, diabetic retinopathy (DR) along with age-related macular degeneration entails progressive vision loss. Since such conditions are associated with the proliferation of novel vessels, their pharmacotherapeutic management consists of the intravitreal injection of anti-vascular endothelial growth factor drugs, able to hinder the driving of vascular proliferation prompted by vascular endothelial growth factor. The humanized anti-vascular endothelial growth factor monoclonal antibody ranibizumab provided evidence for efficacy in several trials, hence earning approval by the US Food and Drug Administration for therapeutic use in all the stages of DR. Due to the lack of epidemiologic and pharmacoeconomic evaluation in the local Calabria Region context, the present retrospective observational study focused on prevalence of DR and age-related macular degeneration, treatment and cost of therapy with ranibizumab in 870 patients arriving to clinical observation at the 'Mater Domini” University Hospital in Calabria, Italy from January 2014 to June 2017. Data were extracted from the database of ophthalmology ward and subjected to statistical analysis. The results suggest that the most frequent retinal diseases are age-related macular degeneration and DR and that the use of ranibizumab has been decreasing over the 4-year study period together with the associated cost per patient which was similar for both disorders. Therefore, appropriateness of treatment with drugs other than ranibizumab needs to be assessed in this setting and deep monitoring of pharmacologic treatment for retinal diseases is necessary to prevent or delay visual acuity decrease and complete vision loss. Study procedures were performed in accordance with the 'Mater Domini” University Hospital ethical standards of the responsible committee on human experimentation. | Damiana Scuteri Ada Vero Mariacristina Zito Maria Diana Naturale Giacinto Bagetta Carlo Nucci Paolo Tonin Maria Tiziana Corasaniti | 2019 | Neural Regeneration Research2019，14，8： | 3 |
| 2 | Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition 显示文摘 | Paille V Picconi B Bagetta V | 2010 | J Neurosci2010，30，14： | 1 |
| 3 | Nitric oxide:induceror suppressor of apoptosis?显示文摘 | Nicotera P Brune B Bagetta G | 1997 | Trends Pharmacol Sci1997，18，6： | 1 |
| 4 | N-methyl-D-aspartate (NMDA) receptor composition modulates dendritic spine morphology in striatal medium spiny neurons 显示文摘 | Vastagh C Gardoni F Bagetta V | 2012 | J Biol Chem2012，287，18： | 1 |
| 5 | Nitric oxide: inducer or suppressor of apoptosis? 显示文摘 | Nicotera P Brune Bagetta G | 1997 | Trends Pharmacol Sci1997，18，6： | 1 |
| 6 | Nitric oxide;inducer or suppressor of apoptosis 显示文摘 | Nicotera P Bmne B Bagetta G | 1997 | Trends Phannacol Sci1997，18，6： | 1 |
| 7 | Synaptic dysfunction in Parkinson's disease 显示文摘 | Bagetta V Ghiglieri V Sgobio C | 2010 | Bioehem Soc Trans2010，38，2： | 1 |
| 8 | Nitric oxide: inducer or suppressor of apoptosis显示文摘 | Nicotera P Brune B Bagetta G | 1997 | Trends in Pharmacological Sciences1997，18，6： | 1 |
| 9 | p73-alpha is capable of inducing Scotin and ER stress 显示文摘 | Terrinoni A Ranalli M Cadot B Leta A Bagetta G Vousden K H | 2004 | Oncogene2004，23，： | 1 |
| 10 | Nitric oxide: inducer or suppressor of apoptosis? 显示文摘 | Nicotera P Brune B Bagetta G | 1997 | Trends Pharmacol Sci1997，18，6： | 1 |
| 11 | From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens显示文摘 | Amantea D Russo R Bagetta G | 2005 | Pharmacol Res2005，52，2： | 1 |
| 12 | Apoptosis in the mechanisms of neuronal plasticity in the developing visual system显示文摘 | Nucci C Piccirillis S Nistic6 R Morrone LA Cetulli L Bagetta G | 2003 | Eur J Ophthalmol2003，13，4： | 1 |
| 13 | Synaptic dysfunction in Parkinson's disease显示文摘 | Bagetta V Ghiglieri V Sgobio C | 2010 | Biochem Soc Trans2010，38，2： | 1 |
| 14 | Identification of distinct cellular pools of interleukin-1β during the evolution of the neuroinflammatory response induced by transient middle cerebral artery occlusion in the brain of rat显示文摘 | Diana Amantea Giacinto Bagetta Cristina Tassorelli | 2010 | Brain Research2010，1313，8： | 1 |
| 15 | From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens 显示文摘 | Amantea D Russo R Bagetta G | 2005 | Pharmacol Res2005，52，2： | 1 |
| 16 | Understanding the Multifaceted Role of Inflammatory Mediators in Ischemic Stroke显示文摘 | D. Amantea C. Tassorelli F. Petrelli M. Certo P. Bezzi G. Micieli M.T. Corasaniti G. Bagetta | 2014 | Current Medicinal Chemistry2014，，18： | 1 |
| 17 | Synaptic dysfunction in Parkinson's disease显示文摘 | Bagetta V Ghiglieri V Sgobio C | 2010 | Biochem Soc Trans2010，38，2： | 1 |
| 18 | Neuropharmacol-ogy of the essential oil of bergamot显示文摘 | Bagetta G Morrone LA* Rombola L | 2010 | Fitoterapia2010，81，6： | 1 |
| 19 | Neuropharmacology of the essential oil of bergamot显示文摘 | BAGETTA G MORRONE L A ROMBOLA L | 2010 | Fitoterapia2010，81，6： | 1 |
| 20 | Neuropharmacology of the essential oil of bergamot 显示文摘 | Bagetta G Morrone LA Rombol th L et | 2010 | Fitoterapia2010，81，6： | 1 |
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