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| 1 | Proteoglycans in liver cancer显示文摘Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain,such as a heparan,dermatan,chondroitin,or keratan sulfate,covalently attached to the protein core.These molecules arecategorized based on their structure,localization,and function,and can be found in the extracellular matrix,on the cell surface,and in the cytoplasm.Cell-surface heparan sulfate proteoglycans,such as syndecans,are the primary type present in healthy liver tissue.However,deterioration of the liver results in overproduction of other proteoglycan types.The purpose of this article is to provide a current summary of the most relevant data implicating proteoglycans in the development and progression of human and experimental liver cancer.A review of our work and other studies in the literature indicate that deterioration of liver function is accompanied by an increase in the amount of chondroitin sulfate proteoglycans.The alteration of proteoglycan composition interferes with the physiologic function of the liver on several levels.This article details and discusses the roles of syndecan-1,glypicans,agrin,perlecan,collagen XVIII/endostatin,endocan,serglycin,decorin,biglycan,asporin,fibromodulin,lumican,and versican in liver function.Specifically,glypicans,agrin,and versican play significant roles in the development of liver cancer.Conversely,the presence of decorin could potentially provide protective effects. | Kornélia Baghy Péter Tátrai Eszter Regős Ilona Kovalszky | 2016 | World Journal of Gastroenterology2016，22，1： | 8 |
| 2 | Elevated miR-33a and miR-224 in steatotic chronic hepatitis Cliver biopsies显示文摘AIM:To assess the expression of selected microRNAs(miRNA) in hepatitis C,steatotic hepatitis C,noninfected steatotic and normal liver tissues.METHODS:The relative expression levels of miR-21,miR-33 a,miR-96,miR-122,miR-125 b,miR-221 and miR-224 were determined in 76 RNA samples isolated from 18 non-steatotic and 28 steatotic chronic hepatitis C(CHC and CHC-Steatosis,respectively) cases,18 non-infected,steatotic liver biopsies of metabolic origin(Steatosis) and 12 normal formalin-fixed paraffin-embedded liver tissues using TaqMan MicroRNA Assays.All CHC biopsy samples were obtained prior to initiating therapy.Patients' serum biochemical values,which included glucose,triglyceride,cholesterol,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl-transferase(GGT),alkaline phosphatase(AP),were obtained and correlated with relative miRNA expression.RESULTS:When compared with control non-infected liver samples,miR-122 and miR-221 levels were reduced in CHC-Steatosis(P < 0.03) and in CHC,CHCSteatosis and Steatosis(P < 0.01).Alternatively,the expression of miR-33 a and miR-224 were elevated in CHC-Steatosis and Steatosis in comparison to control tissue(P < 0.01).The levels of miR-33 a and miR-224 in CHC-Steatosis(P < 0.02) and miR-224 in Steatosis(P < 0.001) were increased in comparison to CHC samples.By contrast,the expression of miR-21 did not differ statistically between diseased and normal liver samples.Levels of miR-33 a correlated negatively with serum AST and AP levels in Steatosis as well as with necroinflammatory grade in CHC,whereas miR-21 correlated positively with AST in Steatosis and displayed negative correlation with triglyceride level in CHC-Steatosis.In contrast,miRNA levels were not correlated with ALT,GGT,cholesterol levels or fibrosis stage.CONCLUSION:Differences in miRNA expression were observed between CHC and steatotic CHC,CHC and steatotic liver,but not between steatotic CHC and steatotic liver of metabolic origin. | Gabor Lendvai Katalin Jármay Gizella Karácsony Tünde Halász Ilona Kovalszky Kornélia Baghy Tibor Wittmann Zsuzsa Schaff András Kiss | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes显示文摘 | Viktória László Katalin Dezs? Kornélia Baghy Veronika Papp Ilona Kovalszky Géza Sáfrány Snorri S. Thorgeirsson Peter Nagy Sándor Paku | 2008 | Histochemistry and Cell Biology2008，，5： | 2 |
| 4 | Severe acute respiratory syndrome coronavirus 2 infection: Role of interleukin-6 and the inflammatory cascade显示文摘Since December 2019,a novel coronavirus that represents a serious threat to human lives has emerged.There is still no definite treatment for severe cases of the disease caused by this virus,named coronavirus disease 2019(COVID-19).One of the most considered treatment strategies targets the exaggerated immune regulator,and interleukin(IL)-6 is a crucial pro-inflammatory mediator.Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)cases show an elevated level of IL-6 related to disease severity.IL-6 activity can be inhibited by the following:IL-6 itself,IL-6 signaling pathways such as Janus kinase and signal transducer and activator of transcription(JAK-STAT),gp130,IL-6R,and downstream activated ILs,such as IL-17 and IL-6 cytokine.Currently,according to these studies and their results,IL-6 blockade with anti-IL-6 or its receptor antibodies such as tocilizumab in COVID-19 is beneficial in severe cases and may reduce the mortality rate.JAK-STAT inhibitors block the cytokine storm by inhibiting several crucial pro-inflammatory mediators such as TNF-αand IL-6 and have shown various results in clinical trials.IL-6 induces IL-17 secretion,and IL-17 is involved in the pathogenesis of inflammatory processes.Clinical trials of anti-IL-17 drugs are currently recruiting,and anti-gp130 antibody is preclinical.However,this agent has shown positive effects in inflammatory bowel disease clinical trials and could be tested for SARS-CoV-2.This study aimed to review the role of IL-6 in the cytokine storm and studies regarding IL-6 and blockade of its inflammatory pathways in COVID-19 to determine if any of these agents are beneficial for COVID-19 patients. | Mohaddeseh Bahmani Rojin Chegini Elham Ghanbari Elham Sheykhsaran Parisa Shiri Aghbash HamedEbrahimzadeh Leylabadlo Ehsan Moradian Amir Masoud Kazemzadeh Houjaghan Hossein Bannazadeh Baghi | 2022 | World Journal of Virology2022，11，3： | 2 |
| 5 | Differentiation of benign and malignant parotid tumors using deconvolution- based perfusion CT imaging:feasibility of the method and initial results显示文摘 | Bisdas S Baghi M Wagenblast J | 2007 | Eur J Radiol2007，64，2： | 1 |
| 6 | AdOnco: a database for clinical and scientific documentation of head and neck oncology显示文摘 | HAMBEK M ADUNKA O BAGHI M | 2006 | Ann Otol Rhinol Laryngol2006，115，2： | 1 |
| 7 | Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice显示文摘 | Baghy K Dezso K L á szl ó V | | 0，，03： | 1 |
| 8 | Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging: Feasibility of the method and initial results显示文摘 | S. Bisdas M. Baghi J. Wagenblast R. Knecht C.H. Thng T.S. Koh T.J. Vogl | 2007 | European Journal of Radiology2007，，2： | 1 |
| 9 | The efficacy of MRI with ultrasmall superparamagnetic iron oxide particles (USPIO) in head and neck cancers显示文摘 | Baghi M Mack MG Hambek M | 2005 | Anticancer Res2005，25，5： | 1 |
| 10 | In vivo proton MR spectrosco- py of primary tumours, nodal and recurrent disease of the extracra- nial head and neck 显示文摘 | Bisdas S Baghi M Huebner | 2007 | Eur Radiol2007，17，1： | 1 |
| 11 | Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging:feasibility of the method and initial results显示文摘 | Bisdas S Baghi M Wagenblast J | 2007 | Eur J Radiol2007，64，2： | 1 |
| 12 | Deeorin-TGF beta axis in hepatic fibrosis and cirrhosis 显示文摘 | Baghy K Iozzo RV Kovalszky I | 2012 | J Histoehem Cytochem2012，60，4： | 1 |
| 13 | Quantitative Measurements of Perfusion and Permeability of Oropharyngeal and Oral Cavity Cancer, Recurrent Disease, and Associated Lymph Nodes Using First-Pass Contrast-Enhanced Computed Tomography Studies显示文摘 | Sotirios Bisdas Mehran Baghi Agnieszka Smolarz | 2007 | Invest Radiol2007，42，3： | 1 |
| 14 | STAT 3 activation in head and neck squamous cell carcinomas is controlled by the EGFR显示文摘 | Hambek M Baghi M Strebhardt K | 2004 | Anticancer Res2004，24，6： | 1 |
| 15 | Quantitative measurements of perfusion and permeability of oropharyngeal and oral cavity cancer, recurrent disease, and associated lymph nodes using first- pass contrast - enhanced computed tomography studies 显示文摘 | Bisdas S Baghi M Smolarz A | 2007 | Invest Radiol2007，42，3： | 1 |
| 16 | Decorin-TGF-βaxis in hepatic fibrosis and cirrhosis显示文摘 | Baghy K Iozzo RV Kovalszky I | 2012 | J Histochem Cytochem2012，60，4： | 1 |
| 17 | Quantitative measurements of perfusion and permeability of oropharyngeal and oral cavity cancer,recurrent disease,and associated lymph nodes using first-pass contrast-enhanced computed tomography studies显示文摘 | Bisdas s Baghi M Smolarz A | | 0，，： | 1 |
| 18 | Preparation and characterization of some cationic starches 显示文摘 | Yoon K J Cart M E Baghy E B | 1992 | J Appl Polym Sci1992，45，6： | 1 |
| 19 | Invivoproton MR spectroscopy of primarytumours, no dal and recurrent disease of the extracrania head and neck显示文摘 | Bisdas S Baghi M Huebner F | 2007 | Eur Radiol2007，17，1： | 1 |
| 20 | In vivo proton MR spectroscopy of primary tumours,nodal and recurrent disease of the extracranial head and neck显示文摘 | Bisdas S Baghi M Huebner F | | 0，，01： | 1 |
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