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| 1 | Controversies in fluid therapy: Type, dose and toxicity显示文摘Fluid therapy is perhaps the most common intervention received by acutely ill hospitalized patients; however, a number of critical questions on the efficacy and safety of the type and dose remain. In this review, recent insights derived from randomized trials in terms of fluid type, dose and toxicity are discussed. We contend that the prescription of fluid therapy is context-specific and that any fluid can be harmful if administered inappropriately. When contrasting ‘‘crystalloid vs colloid'', differences in efficacy are modest but differences in safety are significant. Differences in chloride load and strong ion difference across solutions appear to be clinically important. Phases of fluid therapy in acutely ill patients are recognized, including acute resuscitation, maintaining homeostasis, and recovery phases. Quantitative toxicity(fluid overload) is associated with adverse outcomes and can be mitigated when fluid therapy basedon functional hemodynamic parameters that predict volume responsiveness and minimization of non-essential fluid. Qualitative toxicity(fluid type), in particular for iatrogenic acute kidney injury and metabolic acidosis, remain a concern for synthetic colloids and isotonic saline, respectively. Physiologically balanced crystalloids may be the ‘‘default'' fluid for acutely ill patients and the role for colloids, in particular hydroxyethyl starch, is increasingly unclear. We contend the prescription of fluid therapy is analogous to the prescription of any drug used in critically ill patients. | Robert C McDermid Karthik Raghunathan Adam Romanovsky Andrew D Shaw Sean M Bagshaw | 2014 | World Journal of Critical Care Medicine2014，3，1： | 5 |
| 2 | Short-Term Outcomes of the Australasian Randomized Clinical Study Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The ALCCaS Trial显示文摘 | Peter J. Hewett Randall A. Allardyce Philip F. Bagshaw Christopher M. Frampton Francis A. Frizelle Nicholas A. Rieger J Shona Smith Michael J. Solomon Jacqueline H. Stephens Andrew R. L. Stevenson | 2008 | Annals of Surgery2008，，5： | 3 |
| 3 | Lead alloys: past, present and future 显示文摘 | Bagshaw N E | 1995 | J Power Sources1995，53，6： | 2 |
| 4 | mesoporous-MSU-X metallo- silicate catalysts by non ionic polyethylene oxide surfactant templating acid and base(N^0M^+I^-) catalysed pathways显示文摘 | Bagshaw S A Kemmitt T Milestone N B | 1998 | Microporous and Mesoporous Mater1998，22，： | 1 |
| 5 | 显示文摘 | Bagshaw S A Pinnavaia T J | 1996 | Chem Int Ed Engl1996，35，： | 1 |
| 6 | Intrathecal methotrexate 显示文摘 | Bagshawe KD Magrath IT Golding PR | 1969 | Lancet1969，2，7632： | 1 |
| 7 | Changes in the incidence and out- come tor early acute kidney injury in a cohort of Australian intensive care units显示文摘 | Bagshaw SM George C Bellomo R | 2007 | Crit Care2007，11，3： | 1 |
| 8 | Australasian Laparoscopic Colon Cancer Study shows that elderly patients may benefit from lower postoperative complication rates following laparoscopic versus open resection显示文摘 | Allardyce RA Bagshaw PF Frampton CM | | 0，，01： | 1 |
| 9 | Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury显示文摘 | Bagshaw SM Uchino S Bellomo R | | 0，，： | 1 |
| 10 | Short-term outcomes of the Australasian randomized clinical study comparing laparoscopic and conventional open surgical treatments for colon cancer:the ALCCa S trial显示文摘 | Hewett PJ Allardyce RA Bagshaw PF | 2008 | Ann Surg2008，248，5： | 1 |
| 11 | The utility of laparoscopy in the diagnosis of acute appendicitis in women of reproductive age显示文摘 | Van Dalem R Bagshaw PF Dobbs BR | 2003 | Surg Endosc2003，17，8： | 1 |
| 12 | Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain显示文摘 | Gotman J Grova C Bagshaw A | 2005 | Proc Natl Acad Sci USA2005，42，15： | 1 |
| 13 | Reproductive performance of women successfully treated for gestational trophoblastic tumors显示文摘 | Walden PAM Bagshawe KD | 1976 | Am J Obstet Gynecol1976，125，： | 1 |
| 14 | Treatment of high-risk choriocarcinoma 显示文摘 | Bagshawe KD | 1984 | J Reprod Med1984，29，： | 1 |
| 15 | Traeheostomy: from insertion to decannulation显示文摘 | Engels PT Bagshaw SM Meier M | 2009 | Can J Surg2009，52，： | 1 |
| 16 | Timing of renal re- placement therapy and clinical outcomes in critically ill pa- tients with severe acute kidney injury 显示文摘 | Bagshaw SM Uchino S Bellomo R | 2009 | J Crit Care2009，24，： | 1 |
| 17 | Nodal rhythm and brady-cardia during inhalation induction with sevoflurane in infants:a com-parison of incremental and high-concentration techniques显示文摘 | Green DH Townsend P Bagshaw O | | 0，，03： | 1 |
| 18 | The timing of renal replacement therapy initiation in acute kidney injury 显示文摘 | Bagshaw SM | 2016 | Semin Nephrol2016，36，1： | 1 |
| 19 | Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness显示文摘 | Bagshaw SM Bennett M Haase M | 2010 | Intensive Care Med2010，36，3： | 1 |
| 20 | Electrical impedance tomography of human brain function using reconstruction algorithms based on the finite element method 显示文摘 | Bagshaw AP Liston AD Bayford RH | 2003 | Neurolmage2003，20，2： | 1 |
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