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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Serum Interleukin-10 in Human Acute Pancreatitis显示文摘 | Raffaele Pezzilli Paola Billi Rita Miniero Bahjat Barakat | 1997 | Digestive Diseases and Sciences1997，，7： | 1 |
| 3 | In vivo transduction of thymic dendritic cells with adenovirus and its potential use in acute inflammatory diseases显示文摘 | OBERHOLZER C TSCHOEKE S K BAHJAT K | 2005 | Scand J Immunol2005，61，4： | 1 |
| 4 | In vivo transduction of thymic dendritic cells with adenovirus and its potential use in acute inflammatory diseases显示文摘 | Tschoeke SK Bahjat K | 2005 | Scand J Immunol2005，61，4： | 1 |
| 5 | Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality显示文摘 | Oberholzer A Oberholzer C Bahjat FR | 2001 | J Endotoxin Res2001，7，5： | 1 |
| 6 | Anti-TNF-alphatherapies : the next generation 显示文摘 | Palladino MA Bahjat FR Theodorakis EA | 2003 | Nat Rev Drug Discov2003，2，9： | 1 |
| 7 | Reduced susceptibility of nonobese diabetic mice to TNF-α and D-galactosamine-mediated hepatocellular apoptosis and lethality 显示文摘 | BAHJAT F R DHARNIDHARKA V R FUKUZUKA K | 2000 | Chemical Immunology2000，165，： | 1 |
| 8 | Poly-IC preconditioning protects against cerebral and renal ischemiareperfusion injury显示文摘 | Packard AE Hedges JC Bahjat FR | | 0，，2： | 1 |
| 9 | Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-α and not by Fas ligand显示文摘 | Josephs MD Bahjat FR Fukuzuka K | 2000 | Am J physiol Regul Integr Comp Physiol2000，278，5： | 1 |
| 10 | Anti-TNF-alpha therapies:the next generation显示文摘 | Palladino M A Bahjat F R Theodorakis E A | 2003 | Nat Rev Drug Discov2003，2，9： | 1 |
| 11 | Lipopolysaccharide and D-galactosamine induced hepatic injury is mediated by TNF-α and not by Fas ligand显示文摘 | Josephs MD Bahjat FR Fukuzuka K | 2000 | Am J physiol Regul lntegr Comp physiol2000，278，5： | 1 |
| 12 | Reduced suscep tibility of nonobesediabeticmice to TNF-a and D-galactosamine-mediated epatocellularapop tosis and lethality显示文摘 | Bahjat FR Dharnidharka VR | 2000 | Chem Immunol2000，165，4： | 1 |
| 13 | Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand显示文摘 | Bahjat FR Fukuzuka K | 2000 | Am J Physiol Regul Integr Comp Physiol2000，278，5： | 1 |
| 14 | Study of moving beam plastic hinging zones for earthquake-resistant design of reinforced concrete buildings 显示文摘 | Bahjat Abdel - Fattah James K Wight | 1987 | ACI Structural Journal1987，84，1： | 1 |
| 15 | Anti-TNF-alpha therapies:the next generation显示文摘 | Palladino MA Bahjat FR Theodorakis EA | 2003 | Nat Rev Drug Discov2003，2，9： | 1 |
| 16 | Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice显示文摘 | Deng GM Liu L Bahjat FR | 2010 | Arthritis Rheum2010，62，7： | 1 |
| 17 | Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets显示文摘 | Naumov YN Bahjat KS Gausling R | 2001 | Proc Natl Acad Sci U S A2001，98，13： | 1 |
| 18 | Increased expression of the lymphocyte early activation marker CD69 in peripheral blood correlates with histologic evidence of cardiac allograft rejection显示文摘 | Schowengerdt KO Fricker FJ Bahjat KS | 2000 | Transplantation2000，69，10： | 1 |
| 19 | Activation of CD1 d-re- stricted T cells protects NOD mice from developing diabetes by regu- lating dendritic cell subsets 显示文摘 | Naumov Y N Bahjat K S Gausling R | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 20 | Autoregulation of human monocyte-derived dendritic cell maturation and IL-12 production by cyclooxygenase-2-mediated prostanoid production显示文摘 | WHITTAKER D S BAHJAT K S MOLDAWER L L | 2000 | J Immunol2000，165，： | 1 |
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