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| 1 | Dengue:epidemiology,prevention and pressing need for vaccine development显示文摘Dengue fever is a mosquito born viral infection,and the complicated form of dengue is dengue hemorrhagic fever(DHF).In the recent decades incidence and distribution of dengue has increased dramatically.Dengue viruses belong to family flaviviridae with four serotypes and are transmitted mainly by mosquito Aedes aegypti.Today almost two-fifth of world’s population (2.5 million) is at risk of dengue and no specific antiviral drug or vaccine is available against it.Uncontrolled population growth in Africa and South East Asia has increased number of susceptible hosts in urban and semi urban areas.About 40%of world population resides in the high risk area for dengue transmission.According to latest estimates by WHO,yearly 50 to 100 million infections occur globally,this includes around 500 000 DHF and 22 000 deaths,mostly among children.Only symptomatic treatment in the form of analgesic,antipyretics and body fluid management is provided to the patient.Prevention strategies mainly focus on two approaches, firsdy on activities to control vector and secondly on activities to protect human from mosquito bite but there is always concerns regarding their sustainably and effectiveness.Theoretically development of an effective dengue vaccine is feasible and production of an effective and affordable vaccine could be a viable option to save humans from this dreadful disease. Conceptually vaccine production is possible,but it has to be tetravalent,providing immunity against all serotypes.Few candidate vaccines are in advance stage of their development:however international cooperation is needed to make these vaccines available on cheaper rates to the poor and vulnerable countries.Objective of this review is to discuss various aspects related to dengue,its epidemiology,available preventive methods,need for vaccine and challenges in its development. | Kuldeep Kumar Pankaj Kumar Singh Juhi Tomar Swati Baijal | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 2 |
| 2 | The procell death bcl-2 family member,BNIP3,is localized to the nucleus of human glialcells:implications for glioblastoma multiforme tumor cells urvival under hypoxia显示文摘 | HENSON E S BAIJAL P | 2006 | Int J Cancer2006，118，7： | 1 |
| 3 | Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition显示文摘 | Alimonti JB Shi L Baijal PK | 2001 | JBiol Chem2001，276，10： | 1 |
| 4 | Percutaneous transhepaticbiliary drainage in the management of obstructive jaundice显示文摘 | Baijal SS Dhiman RK Gupta S | 1997 | Trop Gastroenterol1997，18，1： | 1 |
| 5 | The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastomamultiforme tumor cell survival under hypoxia显示文摘 | Burton TR Henson ES Baijal P | 2006 | Int J Cancer2006，，7： | 1 |
| 6 | Endoscopic management of acute calculous cholangitis显示文摘 | Sharma BC Agarwal DK Baijal SS | 1997 | Gastroenterol Hepatol1997，12，： | 1 |
| 7 | Monitoring and management of antituberculosis drug induced hepatotoxicity显示文摘 | Agal S Baijal R Pramanik S | 2005 | Gastroenterol Hepatol2005，20，11： | 1 |
| 8 | Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition 显示文摘 | Alimonti JB Shi L Baijal PK | 2001 | J Biol Chem2001，276，10： | 1 |
| 9 | Endoscopic management of acute calculous cholangitis 显示文摘 | Sharma BC Agarwal DK Baijal SS | 1997 | Gastroenterol Hepatol1997，12，12： | 1 |
| 10 | Pedunculated hepatocellular carcinoma显示文摘 | Kacker L Khan EM Baijal SS | 1994 | Eur J Surg Oncol1994，20，2： | 1 |
| 11 | Epidermoid cyst at a rare location,as a content of inguinal hernia:A case report with a review of the literature显示文摘 | Meher S Baijal M Soni V | 2016 | J Min Access Surg2016，12，3： | 1 |
| 12 | Endoscopic manage- ment of acute calculous cholang it is显示文摘 | Sharma B C Agarwal D K Baijal S S et a l | 1997 | Gastroenterol Hepatol1997，12，12： | 1 |
| 13 | Profile of hepatitis B e antigen-negative chronic hepatitis B显示文摘 | Amarapurkar DN Baijal R Kulshrestha PP | 2002 | Indian J Gastroenternal2002，21，3： | 1 |
| 14 | Effect of Endoscopic Sphincterotomy on Gallbladder Motility显示文摘 | D. K. Agarwal B. C. Sharma R. K. Dhiman S. S. Baijal G. Choudhuri V. A. Saraswat | 1997 | Digestive Diseases and Sciences1997，，7： | 1 |
| 15 | Pancreatic abscess : 10 years experience 显示文摘 | Srikanth G Sikora ss Baijal ss | 2002 | Aust N Z J Surg2002，72，7： | 1 |
| 16 | Facilitating HIV disclo sure across diverse settings: A review显示文摘 | Obermeyer CM Baijal P Pegurri EM | 2011 | American Journal of Public Health2011，101，10： | 1 |
| 17 | The pro-cell death Bcl-2 family member,BNIP3,is localized to the nucleus of human glial cells:Implications for glioblastoma multiforme tumor cell survival under hypoxia显示文摘 | Burton TR Henson ES Baijal P | 2006 | Int J Cancer2006，118，7： | 1 |
| 18 | Effect of endo- scopic sphincterotomy on gallbladder bile lithogenicity and motility显示文摘 | Sharma BC Agarwal DK Baijal SS | 1998 | Gut1998，42，： | 1 |
| 19 | Effect of endoscopic sphincterotomy on gall bladder bile lithogenicity and motility 显示文摘 | Sharma BC Agarwal DK Baijal SS | 1998 | Gut1998，42，2： | 1 |
| 20 | TIPS Can Be Lifesaving in Acute Liver Failure Associated with Portal Vein and Inferior Vena Cava Thrombosis in a Case of Budd Chiari Syndrome Due to Protein S Deficiency显示文摘 | Ashish Verma Gagan Sharma Suyash Mohan Vivek A. Saraswat Sanjay S. Baijal | 2008 | CardioVascular and Interventional Radiology2008，，2： | 1 |
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