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| 1 | Frequency of primary iron overload and HFE gene mutations (C282Y,H63D and S65C) in chronic liver disease patients in north India显示文摘AIM:To identify the frequency of iron overload and study the three mutations in the HFE gene (C282Y,H63D,and S65C) in patients with chronic liver disorders (CLD) and controls. METHODS:To identify patients with iron overload (transferrin saturation > 45% in females and > 50% in males and serum ferritin > 1000 ng/mL) we evaluated 236 patients with CLD,including 59 with non-alcoholic steatohepatitis (NASH),22 with alcoholic liver disease (ALD),19 of cirrhosis due to viruses (HBV,HCV),and 136 with cryptogenic cirrhosis. Mutations of the HFE gene were analyzed by PCR-RE. hundred controls were screened for iron status and the mutations. RESULTS:Seventeen patients with CLD showed evidence of iron overload. Fifteen cases of iron overload had cryptogenic cirrhosis and two had ALD. None of the controls showed iron overload. We did not find any individual with 282Y or 65C either in the cases or in the controls. The prevalence of H63D heterozygosity was 12% in normal individuals,14.8% in 236 patients (16.9% in NASH,13.6% in ALD,26.3% in viral and 12.5% in cryptogenic cirrhosis) and the overall prevalence was 13.98%. Only two of the 17 patients with primary iron overload were heterozygous for H63D. One patient with NASH and one normal individual who were homozygous for H63D showed no iron overload.CONCLUSION:Primary iron overload in Indians is nonHFE type,which is different from that in Europeans and further molecular studies are required to determine the defect in various iron regulatory genes. | Barjinderjit Kaur Dhillon Reena Das Gurjeewan Garewal Yogesh Chawla RK Dhiman Ashim Das Ajay Duseja GR Chandak | 2007 | World Journal of Gastroenterology2007，13，21： | 5 |
| 2 | Elevation of interleukin-18 in chronic hepatitis C: implications for hepatitis C virus pathogenesis 显示文摘 | Sharma A Chakraborti A Das A Dhiman RK Chawla Y | 2009 | Immunology2009，128，1： | 1 |
| 3 | Midline fractures in single maxillary complete acrylic vs flexible dentures显示文摘 | Dhiman RK Chowdhury SR | | 0，，04： | 1 |
| 4 | Minimal hepatic encephalopathy:diagnosis by neuropsychological and neurophysiologic methods显示文摘 | Kharbanda PS Saraswat VA Dhiman RK | 2003 | Indian J Gastroenterol2003，22，2： | 1 |
| 5 | Percutaneous transhepaticbiliary drainage in the management of obstructive jaundice显示文摘 | Baijal SS Dhiman RK Gupta S | 1997 | Trop Gastroenterol1997，18，1： | 1 |
| 6 | Remission of HBV-related Mesangioproliferative Glomerulonephritis after Interferon Therapy显示文摘 | Dhiman RK Kohli HS Das G | 1999 | Nephrol Dial Transplant1999，14，： | 1 |
| 7 | Metformin is effectivein achieving biochemical response in patients withnonalcoholic fatty liver disease ( NAFLD ) not responding tolifestyle interventions 显示文摘 | Duseja A Das A Dhiman RK | 2007 | Ann Hepatol2007，6，4： | 1 |
| 8 | Portal hemodynamics byduplex Doppler sonography in different grades of cirrhosis显示文摘 | Chawla Y Santa N Dhiman RK | 1998 | Dig Dis Sci1998，43，： | 1 |
| 9 | Prognostic uation of early in dicators in fulminant hepatic failure by multivariate analysis显示文摘 | Dhiman RK Seth AK Jain S | 1998 | Dig Dis Sci1998，43，6： | 1 |
| 10 | Minimal hepatic encephalopathy显示文摘 | Dhiman RK Chawla YK | 2009 | IndianJ Gastroenterol2009，28，1： | 1 |
| 11 | Role of paraesophageal collaterals and perforating veins on outcome of endoscopic sclerotherapy for esophageal varice: an endosonographic study显示文摘 | Dhiman RK Choudhuri G Augural DK | 1996 | Gut1996，38，： | 1 |
| 12 | Efficacy of lactulose in cirrhotic patients with subclinical hepatic encephalopathy显示文摘 | Sawhney MS Chawla YK | 2000 | Dig Dis Sci2000，45，： | 1 |
| 13 | Endoscopic scle- rotherapy of gastric variceal bleeding with N-butyl-2-cyanoacry- late显示文摘 | DHIMAN RK CHAWLA Y TANEJA S | 2002 | J Clin Gastroenterol2002，35，9： | 1 |
| 14 | Prevalence and naturalhistory of subclinical hepatic encephalopat hy in cirrhosis 显示文摘 | Das A Dhiman RK Saraswat VA | 2001 | J Gastroenterol Hepatol2001，16，： | 1 |
| 15 | Ascites and spontaneous bacterial peritonitis in fulminant hepatic failure显示文摘 | Dhiman RK Makharia GK Jain S | 2000 | Am J Gastroenterol2000，95，1： | 1 |
| 16 | Induced hypotension in the management of acute hemobilia during therapeutic ERCP in a patient with portal biliopathy (with videos) 显示文摘 | Sharma M Babu CS Dhiman RK | 2010 | Gastrointest Endosc2010，72，6： | 1 |
| 17 | Early indicators of prognosis in fulminant hepatic failure: An assessment of the Model for End-Stage Liver Disease (MELD) and King's College Hospi- tal Criteria显示文摘 | Dhiman RK Jain S Maheshwari U | 2007 | Liver transplantation2007，13，6： | 1 |
| 18 | Review article:the modern management of portal vein thrombosis显示文摘 | Chawla Y Duseja A Dhiman RK | 2009 | Aliment Phannacol Ther2009，30，9： | 1 |
| 19 | Prognostice valuation of early indicator in fulminant hepatic failure multivariate analysis 显示文摘 | Dhiman RK Seth AK Jain S | 1998 | Dig Dis Sci1998，43，6： | 1 |
| 20 | Non - cirrhotic portal fibrosis( idiopathic portal hypertension ) : experiencewith 151 patients and a review of the literature 显示文摘 | Dhiman RK Chawla Y Vasishta RK | 2002 | J Gastroenterol Hepatol2002，17，1： | 1 |
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