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| 1 | Red pigment production by Penicillium purpurogenum GH2 is influenced by pH and temperature显示文摘The combined effects of pH and temperature on red pigment production and fungal morphology were evaluated in a submerged culture of Penicillium purpurogenum GH2, using Czapek-Dox media with D-xylose as a carbon source. An experimental design with a factorial fix was used: three pH values (5, 7, and 9) and two temperature levels (24 and 34 °C) were evaluated. The highest production of red pigment (2.46 g/L) was reached with a pH value of 5 and a temperature of 24 °C. Biomass and red pigment production were not directly associated. This study demon- strates that P. purpurogenum GH2 produces a pigment of potential interest to the food industry. It also shows the feasibility of producing and obtaining natural water-soluble pigments for potential use in food industries. A strong combined effect (p<0.05) of pH and temperature was associated with maximal red pigment production (2.46 g/L). | Alejandro MéNDEZ Catalina PéREZ Julio Cesar MONTAéZ Gabriela MARTíNEZ Cristóbal Noé AGUILAR | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，12： | 4 |
| 2 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 3 | Bamboo shoot processing: food quality and safety aspect (a review)显示文摘 | SATYA S BAL L M SINGHAL P | 2010 | Trends in Food Science&Technology2010，21，4： | 1 |
| 4 | Bamboo shoot: a potential source of food security显示文摘 | SATYA S SINGHAL P BAL L M | 2012 | Mediterranean Journal of Nutritionand Metabolism2012，5，1： | 1 |
| 5 | Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘 | Bal P M De Lange A H Jansen P G W Der Velde M E G V | 2008 | Journal of Vocational Behavior2008，72，1： | 1 |
| 6 | Bamboo shoot processing:food quality and safety aspect:a review显示文摘 | SANTOSH S BAL L M SINGHAL P | | 0，，04： | 1 |
| 7 | Standardization of the quantification of iron concentration in the liver by magnetic resonance imaging显示文摘 | Alústiza J M Emparanzab J I Aldazábal P | | 0，，2： | 1 |
| 8 | Critical evaluation of fiber coatings for organotin determination by using solid phase microextraction in headspace mode显示文摘 | Manuel Bravo M An í bal Valenzuela S Edwar Fuentes P | | 0，，03： | 1 |
| 9 | Bamboo shoots:a novelsource of nutrition and medicine显示文摘 | SINGHAL P BAL L M SATYA S | 2013 | Critical Reviews in Food Scienceand Nutrition2013，53，5： | 1 |
| 10 | From flexibility human re- source management to employee engagement and per- ceived job performance across the lifespan: A multisam- pie study显示文摘 | Bal P M De Lange A H | 2015 | Journal of Occupational and Organizational Psychology2015，88，1： | 1 |
| 11 | Weekly Work Engagement and Performance: A Study among Starting Teachers 显示文摘 | Bakker A B Bal P M | 2010 | Journal of Occu- pational and Organizational Psychology2010，，83： | 1 |
| 12 | Bamboo shoot processing:food quality and safety aspect(a review)显示文摘 | SATYA S BAL L M SINGHAL P | 2010 | Trends in Food Sciense&Technology2010，21，4： | 1 |
| 13 | Selective leaching of antimony and arsenic from mechanically activated tetrahedrite,jamesonite and enargite显示文摘 | BAL(A)(Z) P ACHIMOVI(C)OV(A) M | | 0，，： | 1 |
| 14 | Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response 显示文摘 | Liu P T Stenger S Li H Wenzel L Tan B H Krutzik S R Ochoa M T Schauber J Wu K Meinken C Kamen D L Wagner M Bals R Steinmeyer A Zugel U Gallo R L Eisenberg D Hewison M Hollis B W Adams J S Bloom B R Modlin R L | 2006 | Science2006，311，5768： | 1 |
| 15 | Critical prospective appraisal of renal morphology and function in children undergoing shockwave lithotripsy and percutaneous nephrolithotomy 显示文摘 | Wadhwa P Aron M Bal CS | 2007 | J Endourol2007，21，9： | 1 |
| 16 | Selective leaching of antimony andarsenic from mechanically activated tetrahedrite,jamesonite andenargite显示文摘 | Balá P AchimoviováM | 2006 | International Journal of Mineral Processing2006，81，： | 1 |
| 17 | Psychological contract breach and job attitudes : A meta - analysis of age as a mod- erator 显示文摘 | BAL P M LANGE A H D JANSEN P G W | 2008 | Journal of Vocational Behavior2008，72，1： | 1 |
| 18 | Critical prospective appraisal of renal morphology and functionin children undergoing shockwave lithotripsy and percutaneous nephrolithotomy显示文摘 | Wadhwa P Aron M Bal CS | | 0，，09： | 1 |
| 19 | Influence of chromium and cerium implantation in the electrochemical development of passive layers on AISI 304L显示文摘 | Abreu C M Cristóbal M J Nóvoa X R Pena G Pérez M C Serra C | | 0，，： | 1 |
| 20 | The Separation of Geochemical Anomalies from Background by Fractal Methods 显示文摘 | Cheng Q M Agterberg F P Bal|antyne S B | 1994 | Journal of Geochemical Exploration1994，51，2： | 1 |
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