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| 1 | CircLphn3 protects the blood-brain barrier in traumatic brain injury显示文摘Circular RNAs(circRNAs)are a new and large group of non-coding RNA molecules that are abundantly expressed in the central nervous system.However,very little is known about their roles in traumatic brain injury.In this study,we firstly screened differentially expressed circ RNAs in normal and injured brain tissues of mice after traumatic brain injury.We found that the expression of circ Lphn3 was substantially decreased in mouse models of traumatic brain injury and in hemin-treated b End.3(mouse brain cell line)cells.After overexpressing circ Lphn3 in b End.3 cells,the expression of the tight junction proteins,ZO-1,ZO-2,and occludin,was upregulated,and the expression of mi R-185-5 p was decreased.In b End.3 cells transfected with mi R-185-5 p mimics,the expression of ZO-1 was decreased.Dual-luciferase reporter assays showed that circ Lphn3 bound to mi R-185-5 p,and that mi R-185-5 p bound to ZO-1.Additionally,circ Lphn3 overexpression attenuated the hemin-induced high permeability of the in vitro b End.3 cell model of the blood-brain barrier,while mi R-185-5 p transfection increased the permeability.These findings suggest that circ Lphn3,as a molecular sponge of mi R-185-5 p,regulates tight junction proteins'expression after traumatic brain injury,and it thereby improves the permeability of the blood-brain barrier.This study was approved by the Animal Care and Use Committee of Chongqing Medical University of China(approval No.2021-177)on March 22,2021. | Yu-Qi Cheng Chen-Rui Wu Meng-Ran Du Qiang Zhou Bi-Ying Wu Jia-Yuan-Yuan Fu Ehab Balawi Wei-Lin Tan Zheng-Bu Liao | 2022 | Neural Regeneration Research2022，17，4： | 2 |
| 2 | The effect of honeycomb relative densityon its effective in-plane elastic moduli: an experimentalstudy显示文摘 | Balawi S Abot J L | 2008 | Composite Structures2008，84，4： | 1 |
| 3 | A refined model for the effective in-plane elastic moduli of hexagonal honeycombs 显示文摘 | Balawi S Abot J L | 2008 | Composite Structures2008，84，2： | 1 |
| 4 | Seventeen years of sur- gical treamaent of thymoma: factors influencing survival 显示文摘 | Gamondes JP Balawi A Greenland T | 1991 | Eur J Cardiothorac Surg1991，5，3： | 1 |
| 5 | The effect of honeycomb relative density on its effective in-plane elastic moduli:An experim-enttal study显示文摘 | Balawi S Abot J L | | 0，，84： | 1 |
| 6 | Prevalence of hepatitis B virus markers among blood donors in a tertiary hospital in Tabuk, northwestern Saudi Arabia显示文摘 | Kamel E. El Beltagy Ibrahem A. Al Balawi Maha Almuneef Ziad A. Memish | 2008 | International Journal of Infectious Diseases2008，，5： | 1 |
| 7 | Molecular Interaction Study to Explore the Nigella sativa Bioactive Components as an Inhibitor of Peptide Deformylase to Inhibit the Xanthomonas oryzae pv.oryzae via Applying Computational Approach显示文摘Bacterial leaf blight(BLB)caused by Xanthomonas oryzae pv.oryzae(Xoo)is one of the most damaging diseases to rice across the world.Various chemicals have been employed so far for the management of bacterial leaf blight.On the other hand,these compounds are damaging to the ecosystem and have an impact on non-target species such as humans and animals.As a result,there is a need to create a new natural inhibitor for BLB management.Deformylase(PDF)enzyme is present in all eubacteria and its necessity in bacterial protein synthesis reveals it as an attractive target for drug development.In this study,the active components of Nigella sativa have been selected based on their previously reported antimicrobial activity and screened on the active site of bacterial PDF by the in silico art of techniques.Among these compounds,dithymoquinone and p-cymene strongly bind with the PDF enzyme with binding energy values of 7.77 kcal/mol and 7.26 kcal/mol,respectively,which is comparatively higher than the control compound(−6.73 kcal/mol).Hence,the“dithymoquinone-PDF”and“p-cymene-PDF”complexes were selected for further study,and their stability was assessed by molecular dynamic(MD)simulation.In MD simulation,both selected compounds exhibited steady-state interaction with PDF for 20 ns.It has been hypothesized that p-cymene and dithymoquinone inhibit peptide deformylase and could be used as antibacterials or pesticides against Xoo against the BLB disease. | Pravej Alam Thamer HAl balawi | 2022 | Phyton-International Journal of Experimental Botany2022，91，9： | 0 |
| 8 | 脊髓髓内肿瘤临床治疗研究进展显示文摘原发性脊髓髓内肿瘤发生率较低,约占中枢神经系统肿瘤的2%~4%。为了更好地了解脊髓髓内肿瘤临床治疗进展,该文从临床特征、肿瘤类型、治疗策略和术后并发症等方面阐述了脊髓髓内肿瘤临床治疗研究新进展,旨为临床治疗提供参考。 | Ehab BALAWI 吴碧莹 吴晨瑞(综述) 廖正步(审校) | 2022 | 现代医药卫生2022，38，16： | 0 |
| 9 | Transcriptomic and bioinformatics analysis of the mechanism by which erythropoietin promotes recovery from traumatic brain injury in mice显示文摘Recent studies have found that erythropoietin promotes the recovery of neurological function after traumatic brain injury.However,the precise mechanism of action remains unclea r.In this study,we induced moderate traumatic brain injury in mice by intrape ritoneal injection of erythro poietin for 3 consecutive days.RNA sequencing detected a total of 4065 differentially expressed RNAs,including 1059 mRNAs,92 microRNAs,799 long non-coding RNAs,and 2115circular RNAs.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses revealed that the coding and non-coding RNAs that were differentially expressed after traumatic brain injury and treatment with erythropoietin play roles in the axon guidance pathway,Wnt pathway,and MAPK pathway.Constructing competing endogenous RNA networks showed that regulatory relationship between the differentially expressed non-coding RNAs and mRNAs.Because the axon guidance pathway was repeatedly enriched,the expression of Wnt5a and Ephb6,key factors in the axonal guidance pathway,was assessed.Ephb6 expression decreased and Wnt5a expression increased after traumatic brain injury,and these effects were reversed by treatment with erythro poietin.These findings suggest that erythro poietin can promote recove ry of nerve function after traumatic brain injury through the axon guidance pathway. | Weilin Tan Jun Ma Jiayuanyuan Fu Biying Wu Ziyu Zhu Xuekang Huang Mengran Du Chenrui Wu Ehab Balawi Qiang Zhou Jie Zhang Zhengbu Liao | 2024 | Neural Regeneration Research2024，19，1： | 0 |
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