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| 1 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 2 | Identification of Recalcitrant Stickles and Their Sources in Newsprint Production 显示文摘 | Miranda R Balea A De La Blanca E S | 2008 | Industrial and Engineering Chemistry Research2008，47，16： | 1 |
| 3 | Identification of Re- calcitrant Stickies and Their Sources in Newsprint Production显示文摘 | Miranda R Balea A De La Blanca E S | 2008 | In- dustrial and Engineering Chemistry Research2008，47，16： | 1 |
| 4 | Possible oscillatory behavior in p53-Mdm2 interaction computer simulation 显示文摘 | MIHALAS G I SIMON Z BALEA G | 2000 | Journal of Biological Systems2000，8，1： | 1 |
| 5 | Identification of Re- calcitrant Stickies and Their Sources in Newsprint Production 显示文摘 | Miranda R Balea A De LaBlanca E S | 2008 | In- dustrial and Engineering Chemistry Research2008，47，16： | 1 |
| 6 | Identification of Recalcitrant Stickies and Their Sources in Newsprint Production显示文摘 | Miranda R Balea A Blanca ES | 2008 | Industrial & Engineering Chemistry Research2008，47，16： | 1 |
| 7 | Identification of Recalcitrant Stickies and Their Sources in Newsprint Production显示文摘 | Miranda R Balea A Blanca ES | 2008 | Industrial & Engineering Chemistry Research2008，47，16： | 1 |
| 8 | Identification of Recalcitrant Stickies and Their Sources in Newsprint Production显示文摘 | Miranda R Balea A De La Blanca | 2008 | Industrial and Engineering Chemistry Research2008，47，16： | 1 |
| 9 | Nuclear medicine dynamic investigations in the diagnosis of Budd-Chiari syndrome显示文摘AIM:To investigate the hepatic hemodynamics in the Budd-Chiari syndrome(BCS) using per-rectal portal scintigraphy(PRPS) and liver angioscintigraphy(LAS).METHODS:Fourteen consecutive patients with BCS were evaluated by PRPS between 2003 and 2012.Ten of them underwent LAS and liver scan(LS) with Tc-99m colloid.Eleven patients had clinical manifestations and three were asymptomatic,incidentally diagnosed at PRPS.The control group included 15 healthy subjects.We used new parameters at PRPS,the liver transit time of portal inflow and the blood circulation time between the right heart and liver.PRPS offered information on the hepatic areas missing venous outflow or portal inflow,length and extent of the lesions,open portosystemic shunts(PSS),involvement of the caudate lobe(CL) as an intrahepatic shunt and flow reversal in the splenic vein.LAS was useful in the differential diagnosis between the BCS and portal obstructions,highlightingthe hepatic artery buffer response and reversed portal flow.LS offered complementary data,especially on the CL.RESULTS:We described three hemodynamic categories of the BCS with several subtypes and stages,based on the finding that perfusion changes depend on the initial number and succession in time of the hepatic veins(HVs) obstructions.Obstruction of one hepatic vein(HV) did not cause opening of PSS.The BCS debuted by common obstruction of two HVs had different hemodynamic aspects in acute and chronic stages after subsequent obstruction of the third HV.In chronic stages,obstruction of two HVs resulted in opening of PSS.The BCS,determined by thrombosis of the terminal part of the inferior vena cava,presented in the acute stage with open PSS with low speed flow.At least several weeks are required in the obstructions of two or three HVs for the spontaneous opening of dynamically efficient PSS.The CL seems to have only a transient important role of intrahepatic shunt in several types of the BCS.CONCLUSION:Dynamic nuclear medicine investigations assess the extent and length of hepatic venous obstructions,open collaterals,areas without portal inflow,hemodynamic function of the CL and reverse venous flow. | Mircea Dragoteanu Ioan-Adrian Balea Cecilia-Diana Piglesan | 2014 | World Journal of Hepatology2014，6，4： | 1 |
| 10 | Identification of Recalcitrant Stickies and Their Sources in Newsprint Production显示文摘 | Ruben Miranda Ana Balea et | 2008 | Industrial & Engineering Chemistry Research2008，47，16： | 1 |
| 11 | Airway responses during desflurane versus sevoflurane administration via a laryngeal mask airway in smokers 显示文摘 | Mc Kay RE Bostrom A Balea MC | 2006 | Anesth Analg2006，103，5： | 1 |
| 12 | Identification of Recalcitrant Stickies and Their Sources in Newsprint Production显示文摘 | Miranda R Balea A De La Blanca E S | 2008 | Industrial and Engineering Chemistry Research2008，47，16： | 1 |
| 13 | Small volume of inoculum with an artificial ruman fluid for in vitro digestion of forage显示文摘 | Balea G L Kellogg D W Miller D D | 1976 | J Dairy Sci1976，59，10： | 1 |
| 14 | Tpeak-Tend and Tpeak-Tend Dispersion as Risk Factors for Ventricular Tachycardia/Ventricular Fibrillation in Patients With the Brugada Syndrome显示文摘 | Jesus Castro Hevia Charles Antzelevitch Francisco Tornés Bárzaga Margarita Dorantes Sánchez Francisco Dorticós Balea Roberto Zayas Molina Miguel A. Qui?ones Pérez Yanela Fayad Rodríguez | 2006 | Journal of the American College of Cardiology2006，，9： | 1 |
| 15 | Airway reflexes return more rapidly after desflurane anesthesia than after sevoflurane anesthesia显示文摘 | MCKAY R E LARGE M J BALEA M C | 2005 | Anesth Analg2005，100，3： | 1 |
| 16 | The hedgehog pathway and basle cell earcinoms显示文摘 | Baleae yukp | 2001 | Hum Mol Genet2001，10，7： | 1 |
| 17 | The Organizing of Database from Surlari National Geomagnetic Observatory显示文摘Our paper describes the organizing of database,remarks about SNGO(Surlari National Geomagnetic Observatory)and network infrastructure.Based on the geomagnetic data acquired and stored on the database server,we perform the processing and analysis of geomagnetic parameters through different spectral,statistical and correlation methods.All these parameters are included in the geomagnetic database on server.The web interface for the database meets the different needs of handling the data collected,raw or processed.The server-side programming language used for design is php.This allow us to select different periods for which access to stored data,required for different search filters and different parameters or data from different time periods can be compared.For a more in-depth analysis of the stored data,through JavaScript programming language graphs for different parameters can be drawn.Access to the web interface can be done with or without authentication,depending on the need to ensure the security of certain data collected,stored and processed.The applications are scalable for different devices that will access it:mobile,tablets,laptops or desktops. | Natalia-Silvia Asimopolos Laurentiu Asimopolos Bogdan Balea Adrian Aristide Asimopolos | 2021 | Journal of Environmental Science and Engineering(A)2021，10，1： | 0 |
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