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您的检索式：作者名="Bangwei Luo"
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| 1 | Pentasaccharide resin glycosides from Ipomoea cairica and their cytotoxic activities显示文摘 | Bangwei Yu Jianguang Luo Junsong Wang | 2013 | Phytochemistry2013，95，： | 1 |
| 2 | 巨噬细胞促红细胞生成素信号通路促进凋亡细胞清除及免疫耐受显示文摘机体每秒钟约有10^6个细胞凋亡,如被及时清除则维持机体稳定,反之则导致自身免疫病、慢性炎症、发育异常等,但凋亡细胞吞噬清除机制目前尚未阐明。 | Bangwei Luo Woting Gan Zongwei Liu Zigang Shen Jinsong Wang Rongchen Shi Yuqi Liu Yu Liu Man Jiang 张志仁 吴玉章 | 2017 | 科学新闻2017，19，4： | 0 |
| 3 | Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing显示文摘Dear editor.The remarkably diversified CRISPR-Cas systems in nature have provided unlimited valuable resources to develop genome editing tools that are revolutionizing the fields of biotechnology and medicine.However,due to their microbial origin,the activity of most naturally occurring CRISPR-Cas nucleases is relatively poor in mammalian cells(Ran et al.,2015).Thus,improving the mammalian genome editing efficiency becomes the priority for harnessing more CRISPRCas systems for widespread applications.Rational protein engineering serves as a powerful approach to enhance the catalytic activity of enzymes.Whereas,this approach largely relies on proteinic three-dimension(3D)structure information as guide for design.The fact is that of the large numbers of the CRISPR-Cas systems discovered in recent years,only a small number of them with the 3D structures were reported.To bypass this limitation,here,we report an efficient and simple strategy for rational engineering of Cas nucleases without the need of 3D structure information and successfully optimized nucleases from Cas9 and Cas12 families. | Yangcan Chen Yanping Hu Shengqiu Luo Xinge Wang Bangwei Mao Yi Chen Jing Xu Zhikun Li Qi Zhou Wei Li | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 4 | Macrophage Dicer promotes tolerogenic apoptotic cell clearance and immune tolerance by inhibiting pentose phosphate pathway activity显示文摘Given that apoptosis is the dominant modality of homeostatic cell turnover,efficient clearance of apoptotic cells(ACs),which is a process known as efferocytosis,is critical for immune homeostasis.The phagocytic engulfment of ACs occurs through an immunologically silent process to prevent an immune response to self-antigens.Correspondingly,defects in the removal of ACs have been proposed to underlie the pathogenesis of systemic lupus erythematosus(SLE).1,2 However,pathways that regulate phagocytes for efficient immune-silent AC uptake remain to be fully elucidated.Dicer is best known for its role as a riboendonuclease in the biogenesis of microRNAs.3 While recent studies have determined a link between microRNAs and AC clearance,the interplay between Dicer and efferocytosis remains unknown. | Qiangdongzi Mao Bangwei Luo Jie Mei Wenhua Li Xue Zhang Zhiyu Wang Jiechun Zhang Tingting Liu Fengxue Zhang Zhiren Zhang | 2021 | Cellular & Molecular Immunology2021，18，7： | 0 |
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