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| 1 | Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome显示文摘 | Frebourg T Barbier N Yan Y X Garber J E Dreyfus M Fraumeni J | 1995 | Am J Human Genet1995，56，： | 1 |
| 2 | Brucellosis at the animal/ ecosystem/human interface at the beginning of the 21st century 显示文摘 | Godfroid J Scholz H C Barbier T | 2011 | Preventive Veterinary Medicine2011，102，： | 1 |
| 3 | Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century显示文摘 | Godfroid J Scholz HC Barbier T | | 0，，： | 1 |
| 4 | Brucellosisat the animal/ecosystem/human interface at the beginning ofthe 21st century显示文摘 | GODFROID J SCHOLZ H C BARBIER T | 2011 | Prev Vet Med2011，102，2： | 1 |
| 5 | Oxidation kinetics of natural organic matter by sonolysis and ozone显示文摘 | OLSON T M BARBIER P F | 1994 | Water Environment Research1994，28，6： | 1 |
| 6 | Oxidation kinetics of natural organic matter by sonolysis and ozone 显示文摘 | OLSON T M BARBIER P F | 1994 | Water Research1994，28，6： | 1 |
| 7 | Oxidation kinetics of natural organic matter by sonolysis and ozone 显示文摘 | Olson T M Barbier P F | 1994 | Water Research1994，28，6： | 1 |
| 8 | Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation显示文摘BACKGROUND Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease. These disorders present similar brain/gut/microbiota trialogue alterations, associated with abnormal intestinal permeability, intestinal dysbiosis and colonic hypersensitivity(CHS). Intestinal dysbiosis can alter colon homeostasis leading to abnormal activation of the innate immunity that promotes CHS, perhaps involving the toll-like receptors(TLRs), which play a central role in innate immunity.AIM To understand the mechanisms between early life event paradigm on intestinal permeability, fecal microbiota composition and CHS development in mice with TLRs expression in colonocytes.METHODS Maternal separation model(NMS) CHS model, which mimics deleterious events in childhood that can induce a wide range of chronic disorders during adulthood were used. Colonic sensitivity of NMS mice was evaluated by colorectal distension(CRD) coupled with intracolonic pressure variation(IPV) measurement. Fecal microbiota composition was analyzed by 16S rRNA sequencing from weaning to CRD periods. TLR mRNA expression was evaluated in colonocytes.Additionally, the effect of acute intrarectal instillation of the TLR5 agonist flagellin(FliC) on CHS in adult naive wildtype mice was analyzed.RESULTS Around 50% of NMS mice exhibited increased intestinal permeability and CHS associated with intestinal dysbiosis, characterized by a significant decrease of species richness, an alteration of the core fecal microbiota and a specific increased relative abundance of flagellated bacteria. Only TLR5mRNA expression was increased in colonocytes of NMS mice with CHS. Acute intrarectal instillation of FliC induced transient increase of IPV, reflecting transient CHS appearance.CONCLUSION Altogether, these data suggest a pathophysiological continuum between intestinal dysbiosis and CHS, with a role for TLR5. | Geoffroy Mallaret Amandine Lashermes Mathieu Meleine Ludivine Boudieu Julie Barbier Youssef Aissouni Agathe Gelot Benoit Chassaing Andrew T Gewirtz Denis Ardid Frederic Antonio Carvalho | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 9 | A finite element model for predicting the bio- mechanical behaviour of the human lumbar spine显示文摘 | Pitzen T Geisler F Matthis D Muller-Storz H Barbier D Steudel W I | 2002 | Control Enz Pract2002，10，： | 1 |
| 10 | Terlipressin may influence the outcome of hepatorenal syndrome complicating alcoholic hepatitis显示文摘 | Cervoni JP Lecomte T Cellier C Auroux J Simon C Landi B Gadano A Barbier JP | | 0，，： | 1 |
| 11 | Economic values and incen- tives affecting soil and water conservation in developing countries显示文摘 | Barbier E B Bishop J T | 1995 | Journal of Soil and Water Conservation1995，50，2： | 1 |
| 12 | Respiratory changes in inferior vena cava diameter are helpful in predicting fluid responsiveness in ventilated septic patients显示文摘 | Barbier C Loubieres Y Schmi T | 2004 | Intensive Care Med2004，30，9： | 1 |
| 13 | Myocardial scars more frequent than expected:magnetic resonance imaging detects potential risk group显示文摘 | Barbier CE Bjemer T Johansson L Lind L Ahlstrom H | | 0，，： | 1 |
| 14 | Energy Spectra of Ions Accelerated in Im-pulsive and Gradual Solar Events显示文摘 | REAMES D V BARBIER L M VON ROSENVINGET T | 1997 | Astrophys J1997，483，1： | 1 |
| 15 | Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression 显示文摘 | Claudel T Inoue Y Barbier O | 2003 | Gastroenterology2003，125，： | 1 |
| 16 | Breakage of a volar locking plate after delayed union of a distal radius fracture 显示文摘 | De Baere T Lecouvet F Barbier O | 2007 | Acta Orthop Belg2007，73，6： | 1 |
| 17 | Oxidation kinetics of natural organic matter by sonolysis and ozone 显示文摘 | Olson T M Barbier P F | 1994 | Water Research1994，28，6： | 1 |
| 18 | A high-density consensus map of barley to compare the distribution of QTLs for partial resistance to Puccinia hordei and of defence gene homologues 显示文摘 | MARCEL T C VARSHNEY R BARBIER! M | 2007 | Theoretical and Applied Genetics2007，114，3： | 1 |
| 19 | Oxidation kinetics of natural organic matter by sonolysis and ozone 显示文摘 | OLSON T M BARBIER P F | 1994 | Water Research1994，28，6： | 1 |
| 20 | Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression显示文摘 | CLAUDEL T INOUE Y BARBIER O | 2003 | Gastroenterology2003，125，2： | 1 |
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