|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanisms of triglyceride metabolism in patients with bile acid diarrhea显示文摘Bile acids(BAs) are essential for the absorption of lipids. BA synthesis is inhibited through intestinal farnesoid X receptor(FXR) activity. BA sequestration is known to influence BA metabolism and control serum lipid concentrations. Animal data has demonstrated a regulatory role for the FXR in triglyceride metabolism. FXR inhibits hepatic lipogenesis by inhibiting the expression of sterol regulatory element binding protein 1c via small heterodimer primer activity. Conversely, FXR promotes free fatty acids oxidation by inducing the expression of peroxisome proliferator-activated receptor α. FXR can reduce the expression of microsomal triglyceride transfer protein, which regulates the assembly of very low-density lipoproteins(VLDL). FXR activation in turn promotes the clearance of circulating triglycerides by inducing apolipoprotein C-Ⅱ, very low-density lipoproteins receptor(VLDL-R) and the expression of Syndecan-1 together with the repression of apolipoprotein C-Ⅲ, which increases lipoprotein lipase activity. There is currently minimal clinical data on triglyceride metabolism in patients with bile acid diarrhoea(BAD). Emerging data suggests that a third of patients with BAD have hypertriglyceridemia. Further research is required to establish the risk of hypertriglyceridaemia in patients with BAD and elicit the mechanisms behind this, allowing for targeted treatment. | Nidhi Midhu Sagar Michael McFarlane Chuka Nwokolo Karna Dev Bardhan Ramesh Pulendran Arasaradnam | 2016 | World Journal of Gastroenterology2016，22，30： | 5 |
| 2 | Hybrid ensemble soft computing approach for predicting penetration rate of tunnel boring machine in a rock environment显示文摘This study implements a hybrid ensemble machine learning method for forecasting the rate of penetration(ROP) of tunnel boring machine(TBM),which is becoming a prerequisite for reliable cost assessment and project scheduling in tunnelling and underground projects in a rock environment.For this purpose,a sum of 185 datasets was collected from the literature and used to predict the ROP of TBM.Initially,the main dataset was utilised to construct and validate four conventional soft computing(CSC)models,i.e.minimax probability machine regression,relevance vector machine,extreme learning machine,and functional network.Consequently,the estimated outputs of CSC models were united and trained using an artificial neural network(ANN) to construct a hybrid ensemble model(HENSM).The outcomes of the proposed HENSM are superior to other CSC models employed in this study.Based on the experimental results(training RMSE=0.0283 and testing RMSE=0.0418),the newly proposed HENSM is potential to assist engineers in predicting ROP of TBM in the design phase of tunnelling and underground projects. | Abidhan Bardhan Navid Kardani Anasua GuhaRay Avijit Burman Pijush Samui Yanmei Zhang | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，6： | 2 |
| 3 | Symposium on management of local commons显示文摘 | Bardhan P K | 1993 | The Journal of Economic Perspectives1993，7，4： | 1 |
| 4 | The economist's approach to the problem of corruption显示文摘 | Pranab Bardhan | 2006 | World Development2006，34，2： | 1 |
| 5 | Valuing Mortgage Insurance Contracts in Emerging Market Economies显示文摘 | Bardhan A Karapand R Urosevic B | 2006 | The Journal of Real Estate Finance and Economics2006，，1： | 1 |
| 6 | Pantoprazole in severe acid-peptic disease: the effectiveness and safety of 5 years’ continuous treatment显示文摘 | K.D. Bardhan A.E. Bishop J.M. Polak H.M. Romanska A. Rowland M. Thompson P. Morris S. Schaefer-Preuss R. Luehmann B. McCaldin | 2004 | Digestive and Liver Disease2004，，1： | 1 |
| 7 | Helicobacter pylori eradication does not exacerbate reflux symptoms in gastroeso- phageal reflux disease显示文摘 | Moayyedi P Bardhan C Young L | 2001 | Gastroenterology2001，121，5： | 1 |
| 8 | A double-blind, randomized,placebo-controlled dose-ranging study to eval- uate the efficacy of alosetron in the treatment of irritable bowelsyndrome 显示文摘 | Bardhan KD Bodemar G Geldof H | 2000 | Aliment Pharmacol Ther2000，14，1： | 1 |
| 9 | Understanding the impact of collaboration software on product design and development 显示文摘 | Banker R D Bardhan I Asdemiro | 2006 | Information Systems Research2006，17，4： | 1 |
| 10 | Of blood and guts: association between Helicobacter Pylori and the gastric microcirculation显示文摘 | Kalia N Bardhan K D | 2003 | J Gastroenterol He Patol2003，18，9： | 1 |
| 11 | A note on returns to scale in DEA显示文摘 | R.D. Banker I. Bardhan W.W. Cooper | 1996 | European Journal of Operational Research1996，，： | 1 |
| 12 | Credit Markets and Patterns of Interna-tional Trade显示文摘 | Kletzer K Bardhan P | 1987 | Journal of Development Economics1987，，27： | 1 |
| 13 | The prevention and healing of acute NSAID-associated gastroduodenal mucosaldamage by misoprostol显示文摘 | Bardhan KD Bjarnason I Scott DL | 1993 | Br JRheumatol1993，32，： | 1 |
| 14 | Plant information systems, manufacturing capabilities, and plant performance显示文摘 | Banker R D Bardhan I R | 2006 | MIS Quarterly2006，30，2： | 1 |
| 15 | A double - blind, randomized, placebo- controlled dose -ranging study to evaluate the efficacy of alosetron in the treatment of irritable bowel syndrome 显示文摘 | Bardhan KD Bodemar G Geldof H | 2000 | Aliment Phannacol Ther2000，14，1： | 1 |
| 16 | A double blind, randomized, placebo controlled dose-ranging study to evaluate the efficacy of alosetron in the treat- ment of irritable bowel syndrome 显示文摘 | Bardhan K D Bodemar G Geldof H | 2002 | Aliment Phar macolTher2002，14，1： | 1 |
| 17 | The prevention and healing of acute NSAID-associated gastroduodenal mucosal damage by misoprostol显示文摘 | Bardhan KD Bjarnason I Scott DL | 1993 | Br J Rheumatol1993，32，： | 1 |
| 18 | Understanding the Impact of Collaboration Software on Product Design and Development显示文摘 | Rajiv D. Banker Indranil Bardhan Ozer Asdemir | 2006 | Information Systems Research2006，，4： | 1 |
| 19 | Nonlinear conduction in composites above percolation threshold-beyond the backbone显示文摘 | Bardhan K K | 1997 | Physica (A)1997，241，： | 1 |
| 20 | Tegaserod,a 5-HT4 receptor partial agonist,relieves symptoms in irritable bowel syndrome patients with abdominal pain,bloating and constipation显示文摘 | MULLER-LISSNER SA FUMAGALLI I BARDHAN KD | 2001 | Aliment Pharmscol Ther2001，15，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员