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| 1 | Clinical outcomes of compensated and decompensated cirrhosis: A long term study显示文摘AIM: To study these characteristics and prognostic patterns in a Greek patient population.METHODS: We analyzed a large cohort of cirrhotic patients referred to the department of Gastroenterology and Hepatology and the outpatient clinics of this tertiary hospital, between 1991 and 2008. We included patients with established cirrhosis, either compensated or decompensated, and further decompensation episodes were registered. A data base was maintained and updated prospectively throughout the study period.We analyzed differences in cirrhosis aetiology, time to and mode of decompensation, hepatocellular carcinoma(HCC) occurrence and ultimately patient survival.RESULTS: Five hundreds and twenty-two patients with median age 67(range, 29-91) years and average follow up 9 years-10 mo(range, 1-206 mo) were studied. Commonest aetiology was hepatitis C virus(HCV, 41%) followed by alcohol(31%). The median survival time in compensated cirrhotics was 115 mo(95%CI: 95-133), whereas in decompensated patients was 55 mo(95%CI: 36-75). HCV patients survived longer while HBV patients had over twice the risk of death of HCV patients. The median time to decompensation was 65 mo(95%CI: 51-79), with alcoholics having the highest risk(RR = 2.1 vs HCV patients). Hepatitis B virus(HBV) patients had the highest risk of HCC, alcoholics the lowest. Leading causes of death: liver failure, hepatorenal syndrome, sepsis and HCC progression. CONCLUSION: Cirrhosis aetiology and decompensation at presentation were predictors of survival. Alcoholics had the highest decompensation risk, HBV cirrhotics the highest risk of HCC and HCV cirrhotics the highest decompensation-free time. | Dimitrios N Samonakis Mairi Koulentaki Constantina Coucoutsi Aikaterini Augoustaki Chryssavgi Baritaki Emmanuel Digenakis Nikolaos Papiamonis Maria Fragaki Erminia Matrella Elias A Kouroumalis Maria Tzardi | 2014 | World Journal of Hepatology2014，6，7： | 4 |
| 2 | The Role ofB - RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF - KB/Snail/RKIP/PTEN Circuit 显示文摘 | LIN K BARITAKI S MILITELLO L | 2010 | Genes Cancer2010，1，5： | 1 |
| 3 | The novel role of Yin Yang 1 in the regulation of epithelial to mesenchymal transition in cancer via the dysregulated NF-KB/Snail/YY1/RKIP/PTEN circuitry 显示文摘 | Bonavida B Baritaki S | 2011 | Crit Rev Oncog2011，16，34： | 1 |
| 4 | VEGF,FGF2,TGFB1 and TGFBR1 mRNA expression levels correlate with the malignant transformation of the uterine cervix 显示文摘 | Soufla G Sifakis S Baritaki S et at | 2005 | Cancer Lett2005，221，1： | 1 |
| 5 | Nitric oxide production by pre-implantation embryos in response to embryotoxic factors显示文摘 | Athanassakis I Aifantis I Baritakis S | 2000 | Cell Physiol Biochem2000，10，3： | 1 |
| 6 | Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis:up-regulation of DR5 and inhibition of Yin Yang 1显示文摘 | Baritaki S Huerta-Yepez S Sakai T | | 0，，04： | 1 |
| 7 | Nitric oxide production by pre-implantation embryos in response to embryotoxic factors显示文摘 | Athanassakis I Aifantis I Baritakis S | 2000 | Cell Physiol Biochem2000，10，3： | 1 |
| 8 | Dual role of NO donors in the rever- sal of tumor cell resistance and EMT: downregulation of the NF-KB/Snail/YYI/RKIP circuitry显示文摘 | Bonavida B Baritaki S | 2011 | Nitric Oxide2011，24，： | 1 |
| 9 | Rituximab-mediated upregula- tion of PTEN expression and inhibition of both the PI3K/AKT path- way and pleitrophin (PTN) expression in B-NHL: roles in cell growth inhibition and chemosensitization 显示文摘 | Suzuki E Chen HM Baritaki S | 2006 | Blood2006，108，： | 1 |
| 10 | ChemOtherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis:upregulation of DR6 and inhibition of Yin Yang 1显示文摘 | Baritaki S Huerta-Yepez S Sakai T | 2007 | Mol Cancer Ther2007，6，4： | 1 |
| 11 | Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis:Up-regulation of DR5 and inhibition of Yin Yang 1显示文摘 | Baritaki S Huerta-Yepez S Sakai T | | 0，，04： | 1 |
| 12 | The novel role of Yin Yang 1 in the regula- tion of epithelial to mesenchymal transition in cancer via the dysreg- ulated NF-B/Snail/YY1/RKIP/PTEN Circuitry显示文摘 | Bonavida B Baritaki S | 2011 | Cfit Rev Oncog2011，16，34： | 1 |
| 13 | Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer 显示文摘 | Ren G Baritaki S Marathe H | 2012 | Cancer Research2012，72，12： | 1 |
| 14 | VEGF,FGF2,TGFB1 and TGFBR1 mRNA expression levels correlate with the malignant tranformation of the uterine cervix显示文摘 | Soufla G Sifakis S Baritaki S | 2005 | Cancer Lett2005，221，1： | 1 |
| 15 | K-ras mutation, HPV infection and smoking or alcohol abuse positively cor- relate with esophageal squamous carcinoma 显示文摘 | Lyronis ID Baritaki S Bizakis I | 2008 | Pathol Oncol Res2008，14，3： | 1 |
| 16 | Novel therapeutic applications of nitric oxide donors in cancer: roles in chemo- and immunosensitization to apoptosis and inhibition of metastases显示文摘 | Bonavida B Baritaki S Huerta-Yepez S | 2008 | Nitric oxide2008，19，2： | 1 |
| 17 | The novel role ofYin Yang 1 in the regulation of epithelial to mesenchymal transition in cancer via the dysregulated NF-~cB/Snail/YYI/RKIP/PTEN Circuitry显示文摘 | Bonavida B~ Baritaki S | 2011 | Crit Rev Oncog2011，16，34： | 1 |
| 18 | Dual role of NO donors in the reversal of tumor cell resistance and EMT: Downregulation of the NF-kappa B/Snail/YY 1/RKIP circuitry显示文摘 | Bonavida B Baritaki S | 2011 | Nitric Oxide-Biology and Chemistry2011，24，1： | 1 |
| 19 | Mechanisms of nitric oxide-mediated inhibition of EMT in cancer: inhibition of the metastasis-inducer Snail and induction of the metastasis-suppressor RKIP显示文摘 | Baritaki S Huerta-Yepez S Sahakyan A | 2010 | Cell Cycle2010，9，24： | 1 |
| 20 | TRAF6 activation in multiple myeloma: a potential therapeutic target 显示文摘 | Liu H Tamashiro S Baritaki S | 2012 | Clin Lymphoma Myeloma Leuk2012，12，3： | 1 |
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