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| 1 | Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the'multiple parallel hits'theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD. | Flavia A Cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini | 2017 | World Journal of Gastroenterology2017，23，19： | 9 |
| 2 | 人类角质形成细胞中调节细胞内信号传导的Toll样受体(TLR2)对糠秕马拉色菌的反应显示文摘Toll-like receptors (TLRs) are crucial players in the innate immune response to microbial invaders. The lipophilic yeast Malassezia furfur has been implicated in the triggering of scalp lesions in psoriasis. The aim of the present study was to assess the role of TLRs in the defence against M. furfur infection. The expression of the myeloid differentiation factor 88 (MyD88) gene, which is involved in the signalling pathway of many TLRs, was also analysed. In addition, a possible correlation of antimicrobial peptides of the β -defensin family to TLRs was tested. Human keratinocytes infected with M. furfur and a variety oiM. furfur-positive psoriatic skin biopsies were analysed by RT-PCR, for TLRs, MyD88, human β -defensin 2 (HBD- 2), HBD- 3 and interleukin- 8 (IL- 8) mRNA expression. When keratinocytes were infected with M. furfur, an up-regulation for TLR2, MyD88, HBD- 2, HBD- 3 and IL- 8 mRNA was demonstrated, compared to the untreated cells. The same results were obtained when psoriatic skin biopsies were analysed. The M. furfur-induced increase in HBD- 2 and IL- 8 gene expression is inhibited by anti-TLR2 neutralising antibodies, suggesting that TLR2 is involved in the M. furfur-induced expression of these molecules. These findings suggest the importance of TLRs in skin protection against fungi and the importance of keratinocytes as a component of innate immunity. | Baroni A. Orlando M. Donnarumma G. M.A. Tufano 刘艳 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，3： | 4 |
| 3 | Temperature-and vacancy-concentration-dependence of heat transport in Li_(3)ClO from multi-method numerical simulations显示文摘Despite governing heat management in any realistic device,the microscopic mechanisms of heat transport in all-solid-state electrolytes are poorly known:existing calculations,all based on simplistic semi-empirical models,are unreliable for superionic conductors and largely overestimate their thermal conductivity.In this work,we deploy a combination of state-of-the-art methods to calculate the thermal conductivity of a prototypical Li-ion conductor,the Li_(3)ClO antiperovskite.By leveraging ab initio,machine learning,and force-field descriptions of interatomic forces,we are able to reveal the massive role of anharmonic interactions and diffusive defects on the thermal conductivity and its temperature dependence,and to eventually embed their effects into a simple rationale which is likely applicable to a wide class of ionic conductors. | Paolo Pegolo Stefano Baroni Federico Grasselli | 2022 | npj Computational Materials2022，，1： | 3 |
| 4 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 5 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 6 | Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease显示文摘 | P. Loria L.E. Adinolfi S. Bellentani E. Bugianesi A. Grieco S. Fargion A. Gasbarrini C. Loguercio A. Lonardo G. Marchesini F. Marra M. Persico D. Prati G. Svegliati- Baroni | 2010 | Digestive and Liver Disease2010，，4： | 2 |
| 7 | Viscosity in water from first-principles and deep-neural-network simulations显示文摘We report on an extensive study of the viscosity of liquid water at near-ambient conditions,performed within the Green-Kubo theory of linear response and equilibrium ab initio molecular dynamics(AIMD),based on density-functional theory(DFT).In order to cope with the long simulation times necessary to achieve an acceptable statistical accuracy,our ab initio approach is enhanced with deep-neural-network potentials(NNP).This approach is first validated against AIMD results,obtained by using the Perdew–Burke–Ernzerhof(PBE)exchange-correlation functional and paying careful attention to crucial,yet often overlooked,aspects of the statistical data analysis.Then,we train a second NNP to a dataset generated from the Strongly Constrained and Appropriately Normed(SCAN)functional.Once the error resulting from the imperfect prediction of the melting line is offset by referring the simulated temperature to the theoretical melting one,our SCAN predictions of the shear viscosity of water are in very good agreement with experiments. | Cesare Malosso Linfeng Zhang Roberto Car Stefano Baroni Davide Tisi | 2022 | npj Computational Materials2022，，1： | 2 |
| 8 | PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals显示文摘 | Maria Antonella Burza Carlo Pirazzi Cristina Maglio Kajsa Sj?holm Rosellina Margherita Mancina Per-Arne Svensson Peter Jacobson Martin Adiels Marco Giorgio Baroni Jan Borén Stefano Ginanni Corradini Tiziana Montalcini Lars Sj?str?m Lena Mariana Susann Car | 2012 | Digestive and Liver Disease2012，，12： | 2 |
| 9 | Interferon gamma decreses hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis显示文摘 | Baroni GS Ambrosio D Cuto P | 1996 | Hepatology1996，23，5： | 1 |
| 10 | Intramedullar yhemangioblastoma in a dog显示文摘 | Cantile C Baroni M Tartarelli CL | 2003 | Veterinary Pathology2003，40，1： | 1 |
| 11 | Bile acid-induced lung in- jury in newborn infants: a bronchoalveolar lavage fluid study 显示文摘 | Zecca E De Luca D Baroni S | 2008 | Pediatrics2008，121，1： | 1 |
| 12 | The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life显示文摘 | Stefano Romeo Federica Sentinelli Valentina M Cambuli Michela Incani Tiziana Congiu Vanessa Matta Sabrina Pilia Isabel Huang-Doran Efisio Cossu Sandro Loche Marco G Baroni | 2010 | Journal of Hepatology2010，，2： | 1 |
| 13 | Stress,Stressors and Coping among High School Students显示文摘 | DeAnda D S Baroni L.Boskin L.Buchwald J.Morgan J.Ow J.S.Gold R.Weiss | | 0，，： | 1 |
| 14 | BLIND: a set of se- mantic feature norms from the congenitally blind 显示文摘 | Lenci A Baroni M Caz2011i G | 2013 | Be- hav Res Methods2013，45，4： | 1 |
| 15 | Gadolinium enhancedthree dimensianal MR angiography of takayasu arteritis 显示文摘 | Nastri MV Baptista LP Baroni RH | 2004 | Radiographics2004，24，3： | 1 |
| 16 | Cumulative pregnancy rates after transfer of fresh and thawed embryos显示文摘 | Ubaldi CF Rienzi L Baroni E | 2004 | Eur J Obstetrics Gynecol Reprod Biol2004，115，7： | 1 |
| 17 | Optical satellite networks显示文摘 | Karafolas N Baroni S | 2000 | Journal of Lightwave Technology2000，18，12： | 1 |
| 18 | Gadolinium enhanced three dimensianalMR angiography of takayasu arteritis 显示文摘 | Nastri MV Baptista LP Baroni RH | 2004 | Radio graphics2004，24，3： | 1 |
| 19 | Bile acid-induced lung injury in newborn infants: a bronchoalveolar lavage fuid study显示文摘 | Zecca E De Luca D Baroni S | 2008 | Pediatrics2008，121，1： | 1 |
| 20 | VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3显示文摘 | BARONIE BIFFI M BENIGNI F | 2007 | Leukoc Biol2007，81，1： | 1 |
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