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| 1 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 2 | 定量药理学:一个促进药物开发及转换型研究严谨思考的多学科领域显示文摘尽管从事定量药理学研究的科学工作者一再强调将定量分析的原则应用于促进新药研发的决策,定量药理学的发展还是超过了上述领域。普通研究和决策领域总是期望着常规和传统的研究范例发生进步,当与定量药理学相关的领域自身在发展并与其交互作用时,自然便产生对临床药理学的协同作用。创新性和可塑性训练计划和策略均是将来临床研究工作中必不可少的要素。掌握定量药理学领域的知识成为对药理科学家的要求,具有定量药理学背景的人员可望获得更高的薪水。目前定量药理学相关培训计划,教学资料,及学术权威均比较贫乏,学生们可以从企业化、调控性的背景的教师等多种机构的教职员那获得指导,此外也可以通过在线课程,可视化教学进修课程,与他们的导师保持联系。对课程和学位的管理可以采取灵活的态度,这样可在短期内培养更多的定量药理学工作者。 | Jeffrey S Barrett Michael J Fossler K.David Cadieu Marc R Gastonguay 沈杰 谢海棠 孙瑞元 | 2008 | 中国临床药理学与治疗学2008，13，5： | 10 |
| 3 | Shotcrete Support Design in Blocky Ground: Towards A Deterministic Approach显示文摘 | Barrett S V L McCreath D R | 1995 | Tunnelling and Underground Space Technology1995，10，1： | 1 |
| 4 | De novo sequence as- sembly and characterization of the floral transcriptome in cross-and self-fertilizing plants 显示文摘 | Ness R W Siol M Barrett S C | 2011 | BMC Genom- its2011，12，： | 1 |
| 5 | HDAC3 is a critical negative regulator of long-term memory formation显示文摘 | McQuown S C Barrett R M Matheos D P | 2011 | JNeurosci2011，31，2： | 1 |
| 6 | De novo sequence assembly and charac- terization of the floral transcriptome in cross-and self fertilizing plants 显示文摘 | Ness R W Siol M Barrett S C | 2011 | BMC Genomics2011，2，： | 1 |
| 7 | Seismic and geologic characteristics of drowning events on carbonate platforms显示文摘 | ERLICH R N BARRETT S F JU G B | | AAPG Bulletin0，74，： | 1 |
| 8 | Photoselective potassiumtitanyl-phosphate laser vaporization of the benign obstructive prostate:observations on longterm outcomes显示文摘 | Malek R S Kuntzman R S Barrett D M | 2005 | J Urol2005，174，7： | 1 |
| 9 | Ex- tended-release niacin alters the metabolism of plasma apoli- poprotein (Apo) A-I and Apo B-containing lipoproteins 显示文摘 | Lamon-Fava S DiffenderferM R Barrett PH | 2008 | Arterioscler Thromb Vasc Biol2008，28，： | 1 |
| 10 | Troop size, habitat use, and diet of chacma baboons( Papio hamadryas ursinus)in commercial pine plantations: implications for management 显示文摘 | Henzi S P Brown L R Barrett L | 2011 | International Journal of Primatology2011，32，4： | 1 |
| 11 | Experimental studies on the functional significance of heterostyly显示文摘 | Kohn J R Barrett S C H | 1992 | Evolution1992，46，： | 1 |
| 12 | Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation显示文摘 | Deane J A Pisitkun P Barrett R S | 2007 | Immunity2007，27，5： | 1 |
| 13 | The role of melanocortin 3 and-4 receptor in regula- ting appetite, energy homeostasis and neuroendocrine function in the pig显示文摘 | BARB C R ROBERTSON A S BARRETT J B | 2004 | J Endocrinol2004，181，1： | 1 |
| 14 | Are plant species inherently harder to discriminate than animal species using DNA barcoding markers? 显示文摘 | Fazekas A J Kesanakurti P R Burgess K S Percy D M Graham S W Barrett S C H New- master S G Hajibabaei M Husband B C | 2009 | Mol Ecol Resour2009，9，： | 1 |
| 15 | Patterns ofsimultaneous polysubstance use in drug using universitystudents显示文摘 | Barrett S P Darredeau C Pihl R O | 2006 | Hum Psychopharmacol2006，21，4： | 1 |
| 16 | Peptides on phage:a vast library of peptides for identifying ligands显示文摘 | CWIRLA S E PETERS E A BARRETT R W | 1990 | Proceedings of the National Academy of Sciences of the United States of America1990，87，16： | 1 |
| 17 | NSAID- based γ-secretase modulators do not bind to the amyloid-β poly- peptide显示文摘 | BARRETT P J SANDERS C R KAUFMAN S A | 2011 | Biochemistry2011，50，10： | 1 |
| 18 | The ' science' and ' practice' of HRM in small finns 显示文摘 | MAYSON S BARRETT R | 2006 | Human Resource Management Review2006，16，4： | 1 |
| 19 | Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa显示文摘 | Gerrard S R Li L Barrett A D | 2004 | J Virol2004，78，16： | 1 |
| 20 | Heavier Alkaline Earth Amides as Catalysts for the Tischenko Reaction 显示文摘 | Crimmin M R Barrett A G M Hill M S | 2007 | Org Lett2007，9，2： | 1 |
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