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| 1 | Functional oesophago-gastric junction imaging显示文摘尽管有它在疾病的角色,仍然没有权威的方法估计 oesophago 胃的连接胜任(OGJ ) 。传统地, OGJ 作为指示物与更低的食道的括约肌压力用测压法被估计了。更最近,这被显示了不对倒流是括约肌功能和胜任的一个很可靠的标记。混乱象胃食道的倒流疾病那样并且到更小的 extend 弛缓不能仍然完成病人的一个重要数字。这评论看使用作为阻抗测面积池知道在一只袋子的扩张期间在 OGJ 介绍几何学和压力的一种新技术。收集的数据能被重建进 OGJ 行动的一个动态代表。这被显示了提供 OGJ 的一个有用代表并且由于 endoluminal 治疗以依从和膨胀性显示出变化到 OGJ 的胜任。 | Barry P McMahon Asbjφrn M Drewes Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，18： | 3 |
| 2 | Computation of flow through the oesophagogastric junction显示文摘Whilst methods exist to indirectly measure the effects of increased flow or gastro-oesophageal refluxing, they cannot quantitatively measure the amount of acid travelling back up into the oesophagus during reflux, nor can they indicate the flow rate through the oesophagogastric junction (OGJ). Since OGJ dysfunction affects flow it seems most appropriate to describe the geometry of the OGJ and its effect on the flow. A device known as the functional lumen imaging probe (FLIP) has been shown to reliably measure the geometry of and pressure changes in the OGJ. FLIP cannot directly measure flow but the data gathered from the probe can be used to model flow through the junction by using computational flow dynamics (CFD). CFD uses a set of equations known as the Navier-Stokes equations to predict flow patterns and is a technique widely used in engineering. These equations are complex and require appropriate assumptions to provide simplifications before useful data can be obtained. With the assumption that the cross-sectional areas obtained via FLIP are circular, the radii of these circles can be obtained. A cubic interpolation scheme can then be applied to give a high-resolution geometry for the OGJ. In the case of modelling a reflux scenario, it can be seen that at the narrowest section a jet of fluid squirts into the oesophagus at a higher velocity than the fluid surrounding it. This jet has a maximum velocity of almost 2 ms-1 that occurs where the OGJ is at its narrowest. This simple prediction of acid ‘squirting’ into the oesophagusillustrates how the use of numerical methods can be used to develop a better understanding of the OGJ. This initial work using CFD shows some considerable promise for the future. | Barry P McMahon Karl D Odie Kenneth W Moloney Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，9： | 2 |
| 3 | Do we really understand the role of the oesophagogastric junction in disease?显示文摘The role of the oesophago-gastric junction (OGJ) in gastro-oesophageal reflux disease is still not completely understood, and there is no clinically used method to assess the OGJ function in patients. Only indirect methods such as pH studies are carried out. The OGJ acts a valve controlling the flow of solids, liquids and gases between the oesophagus and the stomach. Manometry can determine if a sphincter is toned or relaxed; but, it cannot confirm that the sphincter region is actually open. Distension is a new technique for measuring function in the OGJ. By measuring the cross-sectional area through the narrow region in the junction during distension of a catheter mounted bag, much more information on the opening and closing patterns of the junction can be determined. This technique has already been demonstrated to show changes in the OGJ after surgical treatments for reflux disease. New measurement ideas around the concept of distending the OGJ offer new hope that a clinically useable test for compliance at the junction can be developed and could potentially help in determining appropriate therapy. | Barry P McMahon Blair A Jobe John E Pandolfino Hans Gregersen | 2009 | World Journal of Gastroenterology2009，15，2： | 1 |
| 4 | Lentiviral vector mediated modification of mesenchymal stem cells and enhanced sur-vival in an in vitro model of ischaemia显示文摘 | McGinley L McMahon J Strappe P Barry F Murphy M Toole D and Brien T | | 0，，12： | 1 |
| 5 | Metagenomic analysis of two enhanced biological phosphorus removal (EBPR) sludge communities 显示文摘 | Martin HG Ivanova N Kunin V Warnecke F Barry KW McHardy AC Yeates C He S Salamov AA Szeto E Dalin E Putnam NH Shapiro HJ Pangilinan JL Rigoutsos I Kyrpides NC Blackall LL McMahon KD Hugenholtz P | 2006 | Nat Biotechnol2006，24，： | 1 |
| 6 | Burnout in the emergency department: Randomized controlled trial of an attention-based training program显示文摘Background: Burnout(encompassing emotional exhaustion, depersonalization and personal accomplishment) in healthcare professionals is a major issue worldwide. Emergency medicine physicians are particularly affected, potentially impacting on quality of care and attrition from the specialty.Objective: The aim of this study was to apply an attention-based training(ABT) program to reduce burnout among emergency multidisciplinary team(MDT) members from a large urban hospital.Design, setting, participants and interventions: Emergency MDT members were randomized to either a notreatment control or an intervention group. Intervention group participants engaged in a four session(4 h/session) ABT program over 7 weeks with a practice target of 20 min twice-daily. Practice adherence was measured using a smart phone application together with a wearable Charge 2 device.Main outcome measures: The primary outcome was a change in burnout, comprising emotional exhaustion, depersonalization and personal achievement. The secondary outcomes were changes in other psychological and biometric parameters.Results: The ABT program resulted in a significant reduction(P < 0.05; T1 [one week before intervention]vs T3 [follow-up at two months after intervention]) in burnout, specifically, emotional exhaustion, with an effect size(probability of superiority) of 59%. Similar reductions were observed for stress(P < 0.05) and anxiety(P < 0.05). Furthermore, ABT group participants demonstrated significant improvements in heart rate variability, resting heart rate, sleep as well as an increase in pro-inflammatory cytokine expression.Conclusion: This study describes a positive impact of ABT on emergency department staff burnout compared to a no-treatment control group. | Pádraic J.Dunne Julie Lynch Lucia Prihodova Caoimhe O'Leary Atiyeh Ghoreyshi Sharee A.Basdeo Donal J.Cox Rachel Breen Ali Sheikhi áine Carroll Cathal Walsh Geraldine McMahon Barry White | 2019 | Journal of Integrative Medicine2019，17，3： | 0 |
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