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| 1 | Serum immunoglobulin A concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease显示文摘AIM:To evaluate the diagnostic accuracy of serum Immunoglobulin A(IgA)for differentiating early stage nonalcoholic fatty liver disease(NAFLD)from nonalcoholic steatohepatitis(NASH).METHODS:All cases had fatty liver change confirmed by ultrasound and aminotransferases of at least twice the normal level.Clinical and biochemical data,including serum IgA,were obtained from 50 histologically proven NAFLD cases and 54 healthy controls.Fasting whole blood samples were obtained from the study population.Immunoturbidimetric methods were used to measure the IgA levels.All NAFLD cases were hospitalized for liver biopsy.Liver specimens were examined for steatosis,steatohepatitis and fibrosis within hepatocytes.Patients were categorized into two groups:NASH and non-NASH.Variables were compared within cases(NASH vs non-NASH)and controls.Cut-off values of serum IgA were evaluated using analysis of receiver operating characteristic(ROC curves).Associations between the variables were tested using calculations of correlation coefficients.Statistical significances were assigned to P values<0.05.RESULTS:The extent of liver fibrosis correlated positively with IgA levels.Subjects with no fibrosis in their liver biopsies had a lower IgA level(301.5±91.2 mg/dL)than subjects with any degree of fibrosis(388.8±140.8 mg/dL),(P=0.01).IgA levels were higher in NASH cases,and its value was significantly higher for higher degrees of fibrosis.Patients with perisinusoidal or pericellular fibrosis had significantly higher levels of IgA(403.5±133.9 mg/dL,418.2±129.5 mg/dL)compared to those without it(301.8±94.9 mg/dL,297.7±91.5 mg/dL),respectively.No significant correlation was found between steatosis grade and serum IgA levels.Based on ROC analysis,the best predictive IgA cutoff value for detecting liver fibrosis was 360mg/dL(61%sensitivity,81%specificity).CONCLUSION:The serum IgA level is useful to evaluate the severity of liver fibrosis and can be used serially for evaluation and follow-up of NAFLD cases. | Iradj Maleki Mahmood Reza Aminafshari Tarang Taghvaei Vahid Hosseini Alireza Rafiei Zhila Torabizadeh Maryam Barzin Elahe Orang | 2014 | World Journal of Gastroenterology2014，20，35： | 4 |
| 2 | Tailoring the wetting properties of polymers from highly hydrophilic to superhydrophobic using UV laser pulses 显示文摘 | Pazokian H Selimis A Barzin J | 2012 | Journal of Micromechanics and Microengineering(S0960-1317)2012，22，3： | 1 |
| 3 | Distributed cra- cking and stiffness degradation in fabric-cement composite显示文摘 | Barzin Mobasher Alva Peled Jitendra Pahilajani | 2006 | Materials and Structures2006，，39： | 1 |
| 4 | Correlation between macrovoid formation and the ternary phase diagram for polyether- sulfone membranes prepared from two nearly similar solvents显示文摘 | Barzin J Sadatnia B | 2008 | J Membr Sci2008，325，1： | 1 |
| 5 | Skeletal muscle GLUT1 transporter protein expression and basal leg glucose uptake are reduced in type 2 diabetes显示文摘 | Ciaraldi TP Mudaliar S Barzin A | 2005 | J Clin Endocrinol Metab2005，90，1： | 1 |
| 6 | Characterization of polyethersulfone hemodialysis membrane by ultrafiltration and atomic force microscopy显示文摘 | Barzin J Feng C Nhulbe K C | 2004 | J Membr Sci2004，237，： | 1 |
| 7 | Incidence of vertebral hemangioma on spinal magnetic resonance imaging in northern iran 显示文摘 | Barzin M Maleki I | 2009 | Pakistan journal of biological sciences: PJBS2009，12，6： | 1 |
| 8 | Characterization of polyethersulfone hemodialysis membrane by ultrafiltrafion and atomic force microsopy显示文摘 | BARZIN J FENG C KHULBE K C | 2004 | Journal of Membrane Science2004，237，： | 1 |
| 9 | Effects of chitosan membrane morphology on copper ion adsorption 显示文摘 | Ghaee A Shariaty - Niassar M Barzin J | 2010 | Chemical Engineering Journal2010，165，1： | 1 |
| 10 | Adverse events fol- lowlng digital replantation in the elderly 显示文摘 | Barzin A Hernandez Boussard T Lee GK | 2011 | J Hand Surg2011，36，5： | 1 |
| 11 | Effects of laparoscopic gastric plication(LGP)in patients with type 2 diabetes,one year follow-up显示文摘 | Talebpour M Talebpour A Barzin G | 2015 | J Diabetes Metab Disord2015，14，： | 1 |
| 12 | 显示文摘 | Barzin J Feng C Khulbe K C | 2004 | Journal of Membrane Sci-ence2004，237，12： | 1 |
| 13 | Multiple magnet ingestion as a source of severe gastrointestinal complications requiring surgical intervention显示文摘 | DUTTA S BARZIN A | 2008 | Arch Pediatr Adolesc Med2008，162，2： | 1 |
| 14 | Finite ele- ment modeling of ballistic impact on multi-layer Kevlar 49 fabrics显示文摘 | Zhu Deiu Aditya Vaidya Barzin Mobasher | 2014 | Composites Part B2014，56，： | 1 |
| 15 | Refractive change induced by the lasik flap in a biomechanical finite element model显示文摘 | Chaitanya D Barzin M Subby D | 2006 | J Refract Surg2006，22，： | 1 |
| 16 | Preparation of Silane-Grafted and Moisture Cross-Linked Low Density Polyethylene: Part I: Factors Affecting Performance of Grafting and Cross-Linking显示文摘 | Jalal Barzin Hamed Azizi Jalil Morshedian | 2006 | Polymer-Plastics Technology and Engineering2006，，8： | 1 |
| 17 | Silane crosslinking of polyethylene: the effects of EVA, ATH and Sb203 on properties of the production in continuous grafting of LDPE 显示文摘 | AZIZI H BARZIN J MORSHEDIAN J | 2007 | eXPRESS Polym Lett2007，1，37： | 1 |
| 18 | Multiple magnet ingestion as a source of severe gastrointestinal complications requiring surgical inter- vention 显示文摘 | Dutta S Barzin A | 2008 | Arch Pediatr AdoleSC Med2008，162，2： | 1 |
| 19 | Modeling of Damage in Cement-based Materials Subjected to External Sulfate Attack I: Formulation显示文摘 | Raphae Tixier Barzin Mobasher ASCE M | 2003 | Journal of Materials in Civil Engineering2003，36，4： | 1 |
| 20 | Abdominal obesity phenotypes and risk of cardiovascular disease in a decade of fol low up: the Tehran lipid and glucose study显示文摘 | Keihani S0 Hosseinpanah F Barzin M | 2014 | Atheroselerosis2014，238，2： | 1 |
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