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| 1 | Ivabradine in the treatment of systolic heart failure- A systematic review and meta-analysis显示文摘AIM To perform a systematic-review and meta-analysis to compare outcomes of ivabradine combined with betablocker to beta-blocker alone in heart failure with reduced ejection fraction(HFr EF).METHODS We searched PubM ed, Cochrane, EMBASE, CINAHL and Web of Science for trials comparing ivabradine + betablocker to beta-blocker alone in HFr EF. We performed a systematic-review and meta-analysis of published literature. Primary end-point was combined end point of cardiac death and hospitalization for heart failure.RESULTS Six studies with 17671 patients were included. Mean follow-up was 8.7 ± 7.9 mo. Combined end-point of heart failure readmission and cardiovascular death was better in ivabradine + beta-blocker group compared to beta-blocker alone(RR: 0.93, 95%CI: 0.79-1.09, P = 0.354). Mean difference(MD) in heart rate was higher in the ivabradine + beta-blocker group(MD: 6.14, 95%CI: 3.80-8.48, P < 0.001). There was no difference in all cause mortality(RR: 0.98, 95%CI: 0.89-1.07, P = 0.609), cardiovascular mortality(RR: 0.99, 95%CI: 0.86-1.15, P = 0.908) or heart failure hospitalization(RR: 0.87, 95%CI: 0.68-1.11, P = 0.271). CONCLUSION From the available clinical trials, ivabradine + betablocker resulted in a significantly greater reduction in HRcoupled with improvement in combined end-point of heart failure readmission and cardiovascular death but with no improvement in all cause or cardiovascular mortality. Given the limited evidence, further randomized controlled trials are essential before widespread clinical application of ivabradine + beta-blocker is advocated for HFrEF. | Mahesh Anantha Narayanan Yogesh NV Reddy Janani Baskaran Abhishek Deshmukh David G Benditt Ganesh Raveendran | 2017 | World Journal of Cardiology2017，9，2： | 5 |
| 2 | Study on vital static properties of fine blanking of GFRP composites with that of conventional drillingl显示文摘 | BASKARAN G GOWRI S KRISHNAMURTHY R | 2010 | Int J Adv Manuf Techno2010，，50： | 1 |
| 3 | MMR/c Abl dependent activation of ING2/p73alpha signaling regulates the cell death response to Nmethyl N' nitro-N nitrosoguanidine显示文摘 | Sun G Jin S Baskaran R | 2009 | Exp Cell Res2009，315，18： | 1 |
| 4 | Shear-wave time of flight diffraction (S-TOFD) technique显示文摘 | Baskaran G Balasubmmaniam K Lakshmana C | 2006 | NDT & E International2006，39，6： | 1 |
| 5 | Ultrasonic TOFD flaw sizing and imaging in thin plates using embedded signal identification technique(ESIT)显示文摘 | Baskaran G Balasubramaniam K Kirshnamurthy C V | 2004 | Insight2004，46，9： | 1 |
| 6 | Ray based model for the ultrasonic time-of-flight diffraction simulation of thin walled structure inspection显示文摘 | Baskaran G Balasubramaniam K Kirshnamurthy C V | 2005 | Journal of Pressure Vessel Technology2005，127，： | 1 |
| 7 | Surface initiated poly merization from carbon nanotubes: strategies and perspec fives显示文摘 | Sakellariou G Priftis D Baskaran D | 2013 | Chem Soc Rev2013，42，2： | 1 |
| 8 | A Convenient Method for theN-Formylation of Secondary Amines and Anilines using Ammoniumformate显示文摘 | Reddy P G KumarG D K Baskaran S | 2000 | Tetrahedron2000，41，： | 1 |
| 9 | Enabling Renew- able Energy and the Future Grid-with Advanced Elec- tricity Storage 显示文摘 | Yang Z G Liu J Baskaran S | 2010 | Minerals Metals and Materials So- ciety2010，62，9： | 1 |
| 10 | Ultrasonic TOFD Flaw Sizing and Imaging in Thin Plates Using Embedded Signal Identification Technique(ESIT)显示文摘 | BASKARAN G KRISHNAN B KRISHNAMURHTY C V | 2004 | Insight (S1354-2575)2004，46，9： | 1 |
| 11 | Synthesis of amphiphilic poly (methyl methacrylate-b-ethylene oxide) copolymers from monohydroxy telechelic poly (methyl methacrylate) as macroinitiator 显示文摘 | Dhara M G Baskaran D Sivaram S | 2008 | J Polym Sci B: Polym Phil2008，46，： | 1 |
| 12 | An inhibitive enzyme assay to detect mercury and zinc using protease from coriandrum sativum 显示文摘 | Baskaran G Masdor N A Syed M A | 2013 | The Science World Journal2013，，： | 1 |
| 13 | How ice enables superconductivity in NaxCoO2·yH2O by melting charge order:possibility of novel electric field effects显示文摘 | Baskaran G | 2005 | Physica C2005，417，： | 1 |
| 14 | A facile, catalytic, and environmentally benign method for selective deprotection of tert-butyldimethylsilyl ether mediated by phosphomolybdic acid supported on silica gel显示文摘 | Kishore G D Baskaran S | | 0，，： | 1 |
| 15 | Ultrasonic TOFD flaw sizing and imaging in thin plates using embedded signal identification technique (ESIT)显示文摘 | BASKARAN G BALASUBRAMANIAM K KRISHN- AMURTHY C V | 2004 | Insight-non-destructive Testing and Condition Monitoring2004，46，9： | 1 |
| 16 | Resonating- valence-bond theory of phase transitions and superconductivity in La_ {2} CuO_ {4}-based compounds显示文摘 | Anderson P W Baskaran G Zou Z | 1987 | Physical review letters1987，58，26： | 1 |
| 17 | Shear-wave time of flight diffractim (S-TOFD) tech- nique 显示文摘 | BASKARAN G BALASUBRAMANIAM K LAKSHMANA RAO C | 2006 | NDT&E International2006，39，6： | 1 |
| 18 | Lead-210 and Polonium-210 in the Winter Well-mixed Turbid Waters in the Mouth of the Yellow Sea 显示文摘 | Hong G H Park S K Baskaran M | 1999 | Continental Shelf Research1999，19，8： | 1 |
| 19 | Simulation of the TOFD technique using the finite element method 显示文摘 | BASKARAN G LAKSHMANA RAO C BALASUBRAMANIAM K | 2007 | Insight2007，49，11： | 1 |
| 20 | Ultrasonic TOFD flaw sizing and imaging in thin plates using embedded signal identification technique (ESIT)显示文摘 | Baskaran G Krishnan B Krishnamurthy C V | 2004 | Insight2004，46，9： | 1 |
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