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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Differential roles of Trk and p75neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo显示文摘 | Bassili M Birman E Schor NF | 2010 | Cancer Chemother Pharmacol2010，65，6： | 1 |
| 3 | Differential roles of Trk and 1375 receptors in tumorigenesis and chemoresistanceex vivoandin vi- vo显示文摘 | Bassili M Birman E Sehor NF | 2010 | Cancer Chemother Pharmacol2010，65，6： | 1 |
| 4 | Safety and Immunogenicity of a quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine in infants and toddlers:three multicenter phase III studies显示文摘 | Pina LM Bassily E Machmer A | 2012 | Pediatric Infect Dis J2012，31，11： | 1 |
| 5 | Introductory evaluation of an oral,killed whole cell enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Egyptian infants显示文摘 | Savarino S J Hall E R Bassily S | | 0，，04： | 1 |
| 6 | Cooperative Security at the Physical Layer: A summary of recent advances 显示文摘 | Bassily R Ekrem E He X et el | 2013 | IEEE Signal Processing Magazine2013，30，3： | 1 |
| 7 | Principles and prac- tice of disaster relief: lessons from Haiti 显示文摘 | Benjamin E Bassily AM Babu E | 2011 | Mt Sinai J Med2011，78，3： | 1 |
| 8 | Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance exvivo and invivo显示文摘 | Bassili M Birman E Schor NF | 2010 | Cancer Chemother Pharmacol2010，65，6： | 1 |
| 9 | A mechatronics educational laboratory-Programmable logic controllers and material handling experiments 显示文摘 | Bassily H Sekhon J Butts E | 2007 | Mechatronics2007，17，9： | 1 |
| 10 | Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo显示文摘 | Bassili M Birman E Schor NF | 2010 | Cancer Chemother Pharmacol2010，65，6： | 1 |
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