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| 1 | Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma显示文摘AIM: To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma (HCC)eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria.METHODS: Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were: (1) histological assessment of tumor grade by means of percutaneous biopsies; (2) determination of AFP mRNA status in the blood; (3) patient's eligibility for radical therapies.RESULTS: At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery (resection or liver transplantation) was performed in 29 patients,while 21 had percutaneous ablation procedures. After a median follow-up of 28 mo, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables (AFP mRNA, HCC grade and gross vascular invasion) resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile (AFP mRNA negative and well-differentiated tumor without gross vascular invasion) as independent survival variables.CONCLUSION: The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies. | Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico | 2005 | World Journal of Gastroenterology2005，11，44： | 12 |
| 2 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 3 | Reversal of axonal loss and disa bility in a mouse model of progressive multiple sclerosis 显示文摘 | Basso A S Frenkel D Quintana FJ Costa-Pinto F A Petrovic Stojkovic S Puckett L | 2008 | J Clin Invest2008，118，： | 1 |
| 4 | Congenital coronary artery anomalies as an important cause of sudden death in the young 显示文摘 | Basso C Corrado D Thiene G | 2001 | Cardiol Rev2001，9，： | 1 |
| 5 | Screening for hypertrophic cardiomyopathy in young athletes显示文摘 | Corrado D Basso C Schiavon M | 1998 | N Engl J Med1998，339，6： | 1 |
| 6 | Assessing potential of biochar for increasing water-holding capacity of sandy soils显示文摘 | Basso A S Miguez F E Laird D A | 2013 | Global Change Biology Bioenergy2013，5，2： | 1 |
| 7 | Decreased total lymphocyte counts in pancreatic cancer:an index of adverse outcome显示文摘 | Fogar P Sperti C Basso D | 2006 | Pancreas2006，32，1： | 1 |
| 8 | 12-lead ECG in the athlete: physiological versus pathological abnormalities显示文摘 | Corrado D Biffi A Basso C | 2009 | Br J Sports Med2009，43，9： | 1 |
| 9 | Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis显示文摘 | Basso AS Frenkel D Quintana FJ | 2008 | J Clin Invest2008，118，4： | 1 |
| 10 | Pre-participation screening of young competitive athletes for prevention of sudden cardiac death显示文摘 | Corrado D Basso C Schiavon M | 2008 | J Am Coll Cardiol2008，52，24： | 1 |
| 11 | Brain network for passive word listening as evaluated with ICA and Granger causality 显示文摘 | Londei A D' Ausilio A Basso D | 2007 | Brain Research Bulletin2007，72，： | 1 |
| 12 | Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS)显示文摘 | BASSO F LOWE G D RUMLEY A | 2002 | Arterioscler Thromb Vasc Biol2002，22，： | 1 |
| 13 | Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transaction 显示文摘 | Basso D M Beattie M S Bresnahan J C | 1996 | Exp Neurol1996，139，2： | 1 |
| 14 | Non-invasive assessment of chronic liver and gastric diseases显示文摘 | Plebani M Basso D | 2007 | Clin Chim Acta2007，，1： | 1 |
| 15 | Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes显示文摘 | Basso C Maron BJ Corrado D | 2000 | J Am Coll Cardiol2000，35，6： | 1 |
| 16 | The tyrosine kinase inhibitor ZD1839(''Iressa'')inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells 显示文摘 | Moasser M M Basso A Averbuch S D | 2001 | Cancer Res2001，61，： | 1 |
| 17 | Arrhythmogenic right ventricularcar diomyopathy显示文摘 | Basso C Thiene G Corrado D | 1996 | Circulation1996，94，5： | 1 |
| 18 | A strategic and tactical management approach to select optimal N fertilizer rates for wheat in a spatially variable field显示文摘 | Basso B Ritchie J T Cammarano D | 2011 | European Journal of Agronomy2011，35，4： | 1 |
| 19 | The S100AS/A9 com- plex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immuno- suppression显示文摘 | Basso D Fogar P Plebani M | 2013 | Oncoimmunology2013，2，24： | 1 |
| 20 | Fuel ethanol alter 25 years显示文摘 | Wheals A E Basso L C Alves D M G | 1999 | Trends Biotechnol1999，，17： | 1 |
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