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| 1 | Statistical design and evaluation of a propranolol HCl gastric floating tablet显示文摘The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet(GFT)of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system.The contents of polyethylene oxide(PEO)WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation.Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time,%drug release at 1 h(D_(1h))and time required to release 90%of the drug(t_(90)).The desired function was used to optimize the response variables,each with a different target,and the observed responses were in good agreement with the experimental values.FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer.The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism.Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state. | Meka Venkata Srikanth Nali Sreenivasa Rao Songa Ambedkar Sunil Battu Janaki Ram Venkata Ramana Murthy Kolapalli | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 6 |
| 2 | Hallmarks in colorectal cancer:Angiogenesis and cancer stem-like cells显示文摘Carcinogenesis is a multistep process that requires the accumulation of various genetic and epigenetic aberrations to drive the progressive malignant transformation of normal human cells.Two major hallmarks of carcinogenesis that have been described are angiogenesis and the stem cell characteristic of limitless replicative potential.These properties have been targeted over the past decade in the development of therapeutic treatments for colorectal cancer(CRC),one of the most commonly diagnosed and lethal cancers worldwide.The treatment of solid tumor cancers such as CRC has been challenging due to the heterogeneity of the tumor itself and the chemoresistance of the malignant cells.Furthermore,the same microenvironment that maintains the pool of intestinal stem cells that contribute to the continuous renewal of the intestinal epithelia also provides the necessary conditions for proliferative growth of cancer stem-like cells.These cancer stem-like cells are responsible for the resistance to therapy and cancer recurrence,though they represent less than 2.5%of the tumor mass.The stromal environment surrounding the tumor cells,referred to as the tumor niche,also supports angiogenesis,which supplies the oxygen and nutrients needed for tumor development.Anti-angiogenic therapy,such as with bevacizumab,a monoclonal antibody against vascular-endothelial growth factor,significantly prolongs the survival of metastatic CRC patients.However,such treatments are not completely curative,and a large proportion of patient tumors retain chemoresistance or show recurrence.This article reviews the current knowledge regarding the molecular phenotype of CRC cancer cells,as well as discusses the mechanisms contributing to their maintenance.Future personalized therapeutic approaches that are based on the interaction of the carcinogenic hallmarks,namely angiogenic and proliferative attributes,could improve survival and decrease adverse effects induced by unnecessary chemotherapy. | Muriel Mathonnet Aurelie Perraud Niki Christou Hussein Akil Carole Melin Serge Battu Marie-Odile Jauberteau Yves Denizot | 2014 | World Journal of Gastroenterology2014，20，15： | 5 |
| 3 | Management of insect pests of cauliflower with biopesticides显示文摘 | Arora R Battu G S Bath D S | 2000 | Indian Journal of Ecology2000，27，： | 1 |
| 4 | Screening procedure for 21 amphetamine-related compounds in urine using solid-phase microextraction and gas chromatography-mass spectrom-etry显示文摘 | Battu C Marquet P Fauconnet AL | 1998 | J Chromatogr Sci1998，36，： | 1 |
| 5 | Contamination of liquid milk and butter with pesticide residues in the Ludhiana district of Punjab state, India显示文摘 | R.S. Battu Balwinder Singh B.K. Kang | 2003 | Ecotoxicology and Environmental Safety2003，，3： | 1 |
| 6 | Retinopathy of prematurity:incidence and risk factors显示文摘 | Rekha S Battu RR | 1996 | Indian Pediatr1996，33，12： | 1 |
| 7 | Effects of glyoxal or methylglyoxal on the metabolism of amino acids, lactate, glucose and acetate in the cerebral cortex of young and adult rats 显示文摘 | Schmidt B de Assis AM Battu CE | 2010 | Brain Res2010，1315，： | 1 |
| 8 | Retinopathy of prematurity: Incidence and risk factors显示文摘 | Rekhat S Battu RR | 1996 | Indian Pediatr1996，33，2： | 1 |
| 9 | Preparation and properties of cellulose nanocomposite fabrics with in situ generated silver nanoparticles by bioreduction method显示文摘The aim of the present study was to develop antibacterial cellulose(cotton)nanocomposite fab-rics(CNCFs)with in situ generated silver nanoparticles using medicinal plant Vitex leaf extract.The developed CNCFs were characterized by scanning electron microscope(SEM),Fourier transform infrared(FT-IR)spectroscopy,X-ray diffraction(XRD)and antibacterial tests.Further,these CNCFs possessed good antibacterial activities.These CNCFs prepared using simple and environmentally friendly method can be considered for medical applications in,such as,surgical aprons,wound cleaning,wound dressing,and hospital bed materials. | Battu Deeksha Vajja Sadanand NHariram Anumakonda Varada Rajulu | 2021 | Journal of Bioresources and Bioproducts2021，6，1： | 1 |
| 10 | Dissipation kinetics of flubendiamide on chili and soil 显示文摘 | Sahoo S K Sharma R K Battu R S | 2009 | Bull Environ Contain Toxico12009，83，： | 1 |
| 11 | Simple and efficient method for the estimation of residues of flubendiamide and its metabolite desiodo flnbendiamide显示文摘 | Battu R S Singh B Kooner R | 2008 | J Agric Food Chem2008，56，： | 1 |
| 12 | Neuropathic pain显示文摘 | Kerstman E Ahn S Battu S | 2013 | Handb Clin Neurol2013，110，： | 1 |
| 13 | Sedimentafion field flow fractionation monitoring of rice starch amylolysis显示文摘 | MORELON X BATTU S SALLSSE C | 2005 | Journal of Chromatography A2005，1093，： | 1 |
| 14 | Transcription of human resistin gene involves an interaction of Spl with peroxisome proliferator-activating receptor gamma(PPAR- gamma) 显示文摘 | Singh AK Battu A Mohareer K | 2010 | PLoS One2010，5，3： | 1 |
| 15 | Sonication Effect on Cellular Material in Sedimentation and Gravitational Field Flow Fractionation显示文摘 | Battu S | 2003 | Journal of Chromatography A2003，1002，： | 1 |
| 16 | Dissipation kinetics of flubendiamide on chili and soil 显示文摘 | SAHOO S K SHARMA R K BATTU R S | 2009 | Bull Environ Contain Toxicol2009，83，： | 1 |
| 17 | Simple and efficient method for the estimation of residues of flubendiamide and its metabolite desiodo flubendiamide显示文摘 | BATTU R S SINGH B KOONER R | 2008 | J Agric Food Chem2008，56，： | 1 |
| 18 | Pharmaceutical applications of hot-melt extrusion:Part Ⅱ显示文摘 | REPKA M A BATTU S K UPADHYE S B | 2007 | Drug Dev Ind Pharm2007，33，10： | 1 |
| 19 | Megakaryocyte cell sorting from diosgenin-differentiated human erythroleukemia cells by sedimentation field-flow显示文摘 | Leger D Y Battu S Liagre B | 2006 | Anal Biochem2006，355，1： | 1 |
| 20 | Retinopathy of prematurity:incidence and risk factors显示文摘 | Rekha S Battu RR | 1996 | Indian Pediatr1996，33，： | 1 |
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