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| 1 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 2 | Current role of palliative interventions in advanced pancreatic cancer显示文摘Pancreatic adenocarcinoma is the third leading cause of cancer death in the United States. Unfortunately, at diagnosis, most patients are not candidates for curative resection. Surgical palliation, a procedure performed with the intention of relieving symptoms or improving quality of life, comes to the forefront of management. This article reviews the palliative management of unresectable pancreatic cancer, including obstructive jaundice, duodenal obstruction and pain control with celiac plexus block. Although surgical bypasses for both biliary and duodenal obstructions usually achieve good technical success, they result in considerable perioperative morbidity and mortality, even when performed laparoscopically. The effectiveness of selfexpanding metal stents for biliary drainage is excellent with low morbidity. Surgical gastrojejunostomy for duodenal obstruction appears to be best for patients with a life expectancy of greater than 2 mo while endoscopic stenting has been shown to be feasible with good symptom relief in those with a shorter life expectancy. Regardless of the palliative procedure performed, all physicians involved must be adequately trained in end of life management to ensure the best possible care for patients. | Chelsey C Ciambella Rachel E Beard Thomas J Miner | 2018 | World Journal of Gastrointestinal Surgery2018，10，7： | 4 |
| 3 | Genetic determinants of altered virulence of Taiwanese foot-and-mouth disease virus显示文摘 | Beard C W Mason P W | 2000 | J Virol2000，74，： | 2 |
| 4 | Influence of environmental temperature on the serologic response of broiler chickens to inactivated and viable new castle disease vaccines显示文摘 | Mitchell B W | 1987 | Avian Disease1987，31，： | 1 |
| 5 | Ectopic expression of Oct4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues显示文摘 | Hochedlinger K Yamada Y Beard C | 2005 | Cell2005，121，3： | 1 |
| 6 | Parkinson′s disease patient-derived induced pluripotent stem cells free of viral reprogramming factors显示文摘 | Soldner F Hockemeyer D Beard C | 2009 | Cell2009，136，5： | 1 |
| 7 | Multiple exciton generation in semiconductor quantum dots 显示文摘 | Beard M C | 2011 | J Phys Chem Lett2011，2，11： | 1 |
| 8 | Iron isotope biosignatures显示文摘 | Beard B L Johnson C M | 1999 | Science1999，285，： | 1 |
| 9 | Mammalian X chromosome inactivation 显示文摘 | Jaenisch R Beard C Lee J | 1998 | Novartis Found Symp1998，214，： | 1 |
| 10 | High Precision iron isotope measurements of terrestrial and lunar material显示文摘 | Beard B L Johnson C M | 1999 | Geochimica et Cosmochimica Acta1999，63，： | 1 |
| 11 | The effect of hyperoxia on cerebral blood flow: a study in healthy volunteers using magnetic resonance phase-contrast angiography显示文摘 | Watson N A Beards S C Altaf N Kassner A Jackson A | 2000 | Eur J Anaesthesiol2000，17，： | 1 |
| 12 | A new model for the equilibrium shape of raindrops显示文摘 | Beard K V Chuang C | 1987 | Journal of the Atmospheric Sciences1987，44，11： | 1 |
| 13 | A numerical model for theequilibrium shape of electrified raindrops显示文摘 | Chuang C Beard K V | 1990 | J Atmos Sci1990，47，： | 1 |
| 14 | Ectopic expression of Oct-4 blocks progenitor-cel differentiation and causes dysplasia in epithelial tissues显示文摘 | Hochedlinger K Yamada Y Beard C | | 0，，03： | 1 |
| 15 | On substructure synthesis with FRF data显示文摘 | Ren Y Beards C F | 1995 | Journal of Sound And Vibration1995，185，5： | 1 |
| 16 | 1 Physical ac-tivity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus显示文摘 | Russo-NeustadtA A Beard R C HuangYM eta | 2000 | Neuro science2000，101，2： | 1 |
| 17 | Pneumocystis colonisation is common among hospitalised HIV infected patients with nonpneumocystis pneumonia显示文摘 | Davis J L Welsh D A Beard C B | 2008 | Thorax2008，63，4： | 1 |
| 18 | A sustainable solution for dietary iron deficiency through plant biotechnology and breeding to increase seed ferritin control显示文摘 | Theil E C Burton J W Beard J L | 1997 | European Journal of Clinical Nutrition1997，51，4： | 1 |
| 19 | Genetic determinants of altered vindence of Taiwanese foot-and-mouth disease virus 显示文摘 | BEARD C W MASON P W | 2000 | Virol2000，74，： | 1 |
| 20 | Are there compartment syndromes in some patients with idiopathic back pain 显示文摘 | Peck D Nicholls PJ Beard C | 1986 | Spine1986，5，： | 1 |
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